Used 2022 Mercedes-Benz S-Class for Sale nearIndianapolis, IN
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,489
- Stock #:
- I8151
- VIN:
- W1K6G6DB7NA128151


Sponsored by Fishers Imports
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,489 mi
$52,284
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Cirrus Silver
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,988
- Stock #:
- STK125898
- VIN:
- W1K6G6DB2NA125898

Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
25,988 mi
$55,990
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,231
- Stock #:
- WJ3497
- VIN:
- W1K6G7GB6MA033497

Sponsored Listing
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
22,231 mi
$61,699
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,568
- Stock #:
- 129604
- VIN:
- W1K6G7GBXNA129604

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
36,568 mi
$69,533
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 80,861
- Stock #:
- C21009153
- VIN:
- W1K6G7GB9MA026057

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
80,861 mi
$44,965
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 59,720
- Stock #:
- 139870
- VIN:
- W1K6G7GB4NA139870

-$7,099
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
59,720 mi
$63,577
$57,577
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 1,324
- Stock #:
- J9150
- VIN:
- W1K6G7GB1PA179150

2023 Mercedes-Benz S-Class
S 580 4MATIC AWD
1,324 mi
$86,749
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,775
- Stock #:
- J8239
- VIN:
- W1K6G7GB3NA068239

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,775 mi
$63,699
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 982
- Stock #:
- PM6816
- VIN:
- W1K6G6DB5PA180736

2023 Mercedes-Benz S-Class
S 500 4MATIC AWD
982 mi
$74,836
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,914
- Stock #:
- 073281
- VIN:
- W1K6G7GB5NA073281

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
58,914 mi
$60,137
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (TAN)
- Transmission:
- Automatic
- Mileage:
- 40,239
- Stock #:
- 70263707
- VIN:
- W1K6G7GB4NA149282

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
40,239 mi
$66,997
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,312
- Stock #:
- P074582
- VIN:
- W1K6G6DB4NA074582

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,312 mi
$57,745
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,821
- Stock #:
- 070016
- VIN:
- W1K6G6DB6NA070016

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
45,821 mi
$54,599
CarGurus Analysis:
2022 Mercedes-Benz S-Class
With 220 currently listed for sale near Indianapolis, IN and an average price of $57,794, 24.1% of 2022 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz S-Class 4.5 / 5 stars and CarGurus experts gave it an 8.67 / 10.
85.9% of 2022 S-Class models on CarGurus are accident free.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,685
- Stock #:
- 1D0488A
- VIN:
- W1K6G6DB0NA086793

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
35,685 mi
$56,614
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 22,301
- Stock #:
- M848A
- VIN:
- W1K6G7GB2NA131587

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
22,301 mi
$69,076
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,607
- Stock #:
- 096095
- VIN:
- W1K6G7GB2NA096095

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
52,607 mi
$63,137
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 27,975
- Stock #:
- 7159
- VIN:
- W1K6G6DB1PA186579

2023 Mercedes-Benz S-Class
S 500 4MATIC AWD
27,975 mi
$63,902
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 33,358
- Stock #:
- 170464
- VIN:
- W1K6G6DB3PA170464

2023 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,358 mi
$57,293
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,200
- Stock #:
- 023555
- VIN:
- W1K6G7GBXMA023555

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,200 mi
$58,316
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 38,465
- Stock #:
- 189705
- VIN:
- W1K6G7GB4PA189705

2023 Mercedes-Benz S-Class
S 580 4MATIC AWD
38,465 mi
$75,011
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 40,531
- Stock #:
- 127219
- VIN:
- W1K6G6DBXNA127219

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
40,531 mi
$54,371
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,044
- Stock #:
- PA171855M
- VIN:
- W1K6G7GBXPA171855

2023 Mercedes-Benz S-Class
S 580 4MATIC AWD
58,044 mi
$65,791
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,371
- Stock #:
- STK156393
- VIN:
- W1K6G6DB6NA156393

Sponsored Listing
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,371 mi
$58,990
CarGurus Analysis: 2022 Mercedes-Benz S-Class
overall

Summary
With 220 currently listed for sale near Indianapolis, IN and an average price of $57,794, 24.1% of 2022 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz S-Class 4.5 / 5 stars and CarGurus experts gave it an 8.67 / 10.
85.9% of 2022 S-Class models on CarGurus are accident free.
Why it stands out
The 2022 Mercedes-Benz S-Class stands out as a full-size four-door luxury sedan that aims to define modern executive transportation. Its appeal starts with a 48-volt mild hybrid gasoline-electric powertrain and continues with a choice of a turbocharged 3.0-liter inline six-cylinder gas engine in the S500 or a twin-turbo 4.0-liter V8 in the S580. Both versions use EQ Boost, a nine-speed automatic transmission, and all-wheel drive, giving the car a technical and upscale character that matches its flagship mission.
Beyond the hardware, the 2022 S-Class is distinguished by its stylish design, great ride quality, and premium interior materials. Those strengths make it especially attractive to buyers who want a luxury sedan that feels polished and substantial. The tradeoff is that its design may be polarizing, and there is no getting around the high price tag, with the S500 starting at $111,100 and the S580 starting at $117,700. Fuel economy is also mixed depending on the engine, with the S500 rated at up to 21 mpg city, 30 mpg highway, and 24 mpg combined, while the S580 is rated at 16 mpg city, 25 mpg highway, and 19 mpg combined.
Other model years to consider
- Average price: $26,707
- Good/great deal percentage: 29.3%
- User rating: 4.95 / 5
- Total listings: 205
- Average price: $86,500
- Good/great deal percentage: 25.0%
- Total listings: 244
- Average price: $17,560
- Good/great deal percentage: 30.1%
- User rating: 5 / 5
- Total listings: 153
This analysis is based on CarGurus' proprietary market data from September 28, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
4.5 Overall rating
Filter by rating
Nabeel J
Reviewed a 2022 Mercedes-Benz S-Class on Apr 25, 2022
The S Class provides safety and comfort for its riders. At first, I decided to purchase the BMW 745e after comparing it with the Audi A8. I decided to give the Mercedes S class a try. After the test drive, I immediately decided to purchase the Mercedes S580. I do not regret my purchase at all. All of the looks of the car look fabulous. The ambient lighting is breathtaking as well as the display screen. The panoramic sunroof is also one of my favorites. I live in a hilly area, but I can’t even tell when going up the hill since the S580 is a powerful vehicle.
Sajid S
Reviewed a 2022 Mercedes-Benz S-Class on Dec 27, 2021
It’s been a pinnacle of luxury, however nothing stands out compared to previous models except some businesses including indoor lighting etc. the screen seems odd ;stands out in the middle and does not merge with the rest of the dashboard
Anonymous
Reviewed a 2022 Mercedes-Benz S-Class on Jun 7, 2024
The only option I wish it had was the premier stereo system. Otherwise the car was perfect. It was basically a new vehicle. The price I actually paid was great based on the immaculate condition and very low mileage.
Joyce E
Reviewed a 2022 Mercedes-Benz S-Class on Apr 18, 2024
This car has a manufacturer recall on its fuel pump mechanism, and it is a hybrid car, so for someone who leaves the car parked in the garage for 2 straight weeks, it may cause the battery to die and may not be suited for my needs/lifestyle
Compare 2022 Mercedes-Benz S-Class Trims in Indianapolis, IN
The S-Class offers a blend of luxury and performance, with options ranging from the value-focused S 500 to the high-end Maybach trims.
- Starting at $55,908
- Best MPG/MPGe: 21 city / 30 hwy
- Most Popular: S 580 4MATIC AWD
Trim Overview
Prices updated weekly from CarGurus listings.
| S 500 4MATIC AWD | S 580 4MATIC AWD (Most Popular) | Maybach S 580 4MATIC AWD | Maybach S 680 4MATIC AWD | |
|---|---|---|---|---|
| Starting MSRP | $111,100 | $117,700 | $184,900 | $229,000 |
| Avg. Market Price | $55,908 | $63,492 | $57,804 | $57,804 |
| Positioning | Best value | Adventure-ready | Adventure-ready | Trail-ready |
| Standout Features | Blind Spot Monitoring, Navigation System, Heated Seats | Backup Camera, Navigation System, Blind Spot Monitoring | Heated Seats, Backup Camera, Navigation System | Heated Seats, Backup Camera, Navigation System |
| Drivetrain | AWD | AWD | AWD | AWD |
| Listings Available | 52 | 104 | 22 | 17 |
Quick Compare Table
Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.
| S 500 4MATIC AWD | S 580 4MATIC AWD | Maybach S 580 4MATIC AWD | Maybach S 680 4MATIC AWD | |
|---|---|---|---|---|
| AI Summary | Best value in the S-Class lineup | Most popular luxury option available | Premium luxury with advanced features | Ultimate luxury with powerful performance |
| Avg. Market Price | $55,908 | $63,492 | $57,804 | $57,804 |
| MSRP | $111,100 | $117,700 | $184,900 | $229,000 |
| Engine | 3.0L 429 hp I6 | 4.0L 496 hp V8 | 4.0L 496 hp V8 | 6.0L 621 hp V12 |
| Drivetrain | AWD | AWD | AWD | AWD |
| MPG/MPGe (City/Hwy) | 21/30 | 16/25 | 15/24 | 12/21 |
| Blind Spot Monitoring | ✓ | ✓ | ✓ | ✓ |
| Backup Camera | ✓ | ✓ | ✓ | ✓ |
| Navigation System | ✓ | ✓ | ✓ | ✓ |
| Heated Seats | ✓ | ✓ | ✓ | ✓ |
| Bluetooth | ✓ | ✓ | ✓ | ✓ |
| Adaptive Cruise Control | ✓ | ✓ | ✓ | ✓ |
| Leather Seats | ✓ | ✓ | ✓ | ✓ |
| CarPlay | ✓ | ✓ | ✓ | ✓ |
| Android Auto | ✓ | ✓ | ✓ | ✓ |
| Adaptive Suspension | ✓ | ✓ | ✓ | ✓ |
| Active Listings | 52 | 104 | 22 | 17 |
Missing data displayed as "—".
Trim Deep Dives
S 500 4MATIC AWD — "Who It's For"
The S 500 is the pick for shoppers who want luxury features without the higher price of the S 580. It's a great entry point into the S-Class.
- Avg. market price: $55,908 (updated weekly)
- MPG/MPGe: 21 city / 30 hwy
- Inventory: 52 listings
- View S 500 4MATIC AWD listings
S 580 4MATIC AWD — "Who It's For"
The S 580 is the pick for shoppers who want a powerful V8 engine and a wealth of luxury features. It's the most popular trim in the lineup.
- Avg. market price: $63,492 (updated weekly)
- MPG/MPGe: 16 city / 25 hwy
- Inventory: 104 listings — widest selection in the lineup
- View S 580 4MATIC AWD listings
Maybach S 580 4MATIC AWD — "Who It's For"
The Maybach S 580 is the pick for shoppers who want the ultimate in luxury without stepping up to the V12. It offers a premium experience.
- Avg. market price: $57,804 (updated weekly)
- MPG/MPGe: 15 city / 24 hwy
- Inventory: 22 listings
- View Maybach S 580 4MATIC AWD listings
Maybach S 680 4MATIC AWD — "Who It's For"
The Maybach S 680 is the pick for shoppers who want the most powerful engine and the highest level of luxury. It's a statement vehicle.
- Avg. market price: $57,804 (updated weekly)
- MPG/MPGe: 12 city / 21 hwy
- Inventory: 17 listings — lower availability; may limit negotiating room
- View Maybach S 680 4MATIC AWD listings
Trim Recommendations
Most Popular — S 580 4MATIC AWD
With 104 active listings, the S 580 4MATIC AWD is the clear volume leader in the lineup.
Browse S 580 4MATIC AWD listings
Best Budget Option — S 500 4MATIC AWD
At $55,908 avg market price — below the lineup median of $57,804 — it's the most accessible entry point.
Browse S 500 4MATIC AWD listings
Best for Fuel Economy — S 500 4MATIC AWD
With an impressive MPG/MPGe of 21/30, the S 500 is the most fuel-efficient option in the lineup.
Browse S 500 4MATIC AWD listings
These recommendations are based on CarGurus' proprietary market data from September 24, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
2022 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz S-Class prices has changed over time.
See more price trends2022 Mercedes-Benz S-Class Pricing Analysis: Indianapolis, IN Market Report
Pricing by Nearby Locations
Market Area: Indianapolis, IN
Key Insights
- Highest Prices in Urban Areas: Columbus, IN ($79,898) and Bloomington, IN ($79,898) show the highest average prices, likely due to higher demand in urban settings.
- Lowest Prices in Smaller Markets: Anderson, IN ($57,932), Crawfordsville, IN ($57,932), and Kokomo, IN ($57,932) offer the lowest prices, indicating a more price-sensitive market or higher inventory turnover.
- Inventory Levels: Cities like Columbus and Bloomington have a moderate number of listings (231 each), suggesting a balanced supply relative to demand.
City-Level Pricing
| City | Total Listings | Avg Price |
|---|---|---|
| Columbus, IN | 231 | $79,898 |
| Bloomington, IN | 229 | $79,898 |
| Anderson, IN | 226 | $57,932 |
| Crawfordsville, IN | 221 | $57,932 |
| Kokomo, IN | 226 | $57,932 |
| Lafayette, IN | 229 | $58,100 |
| Jasper, IN | 227 | $68,449 |
Pricing by Trim Packages
Key Insights
- AWD Trims Dominate Inventory: The S 580 4MATIC AWD trim leads with 104 listings, reflecting strong demand for luxury AWD vehicles.
- Price Variability Across Trims: The Maybach S 680 4MATIC AWD is the most expensive trim at $229,000 MSRP, indicating a significant premium for luxury features.
- Value Proposition of Base Trims: The S 500 4MATIC AWD offers a competitive entry point at $111,100 MSRP with a solid feature set, appealing to buyers seeking luxury without the highest price tag.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| S 580 4MATIC AWD | 104 | $117,700 | AWD | 4.0L 496 hp V8 |
| S 500 4MATIC AWD | 52 | $111,100 | AWD | 3.0L 429 hp I6 |
| Maybach S 580 4MATIC AWD | 22 | $184,900 | AWD | 4.0L 496 hp V8 |
| Maybach S 680 4MATIC AWD | 18 | $229,000 | AWD | 6.0L 621 hp V12 |
Pricing Analysis by Model Year
Key Insights
- New Models Command Premium Prices: The 2025 model is priced at $152,990, reflecting a 29.9% increase over its MSRP, indicating strong demand for the latest model.
- Significant Depreciation for Older Models: The 2015 model shows the steepest decline, with an average price of $26,769, down 71.6% from its original MSRP.
- Best Value in Recent Models: The 2023 model is priced at $86,500, representing a 24.4% decrease from its MSRP, making it a compelling option for buyers looking for a balance of luxury and value.
Model Year Pricing
| Model Year | Original MSRP | Avg Price | Price vs MSRP |
|---|---|---|---|
| 2025 Mercedes-Benz S-Class | $117,750 | $152,990 | +29.9% |
| 2024 Mercedes-Benz S-Class | $117,300 | $133,990 | +14.3% |
| 2023 Mercedes-Benz S-Class | $114,500 | $86,500 | -24.4% |
| 2021 Mercedes-Benz S-Class | $109,800 | $61,450 | -44.0% |
| 2019 Mercedes-Benz S-Class | $91,250 | $40,995 | -55.0% |
| 2018 Mercedes-Benz S-Class | $89,900 | $37,447 | -58.3% |
| 2017 Mercedes-Benz S-Class | $96,600 | $48,569 | -49.7% |
| 2016 Mercedes-Benz S-Class | $95,650 | $30,349 | -68.3% |
| 2015 Mercedes-Benz S-Class | $94,400 | $26,769 | -71.6% |
These recommendations are based on CarGurus' proprietary market data from September 23, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
How much does the 2022 Mercedes-Benz S-Class cost?
| Metric | Value |
|---|---|
| Current Average Price | $63,211 |
| Year-Round Low | $63,170 |
| Year-Round High | $70,611 |
| Average Price a Year Ago | $70,601 |
| Change vs. Last Year | −10.47% |
Prices have softened 10.47% compared to this time last year, making it a favorable time to shop this model year.
There are 1,130 listings available, which gives you a meaningful amount of inventory to compare.
Is the 2022 Mercedes-Benz S-Class a good car?
Yes — the 2022 Mercedes-Benz S-Class earns a 4.5/5 user rating and an 8.67/10 expert rating. The model scores 9/10 across Look and feel, Form and function, Technology, and Safety.
You’re looking at a full-size luxury sedan that emphasizes a polished cabin, advanced tech, and a serene driving experience. The overview and expert notes point to a flagship sedan with premium materials, strong ride quality, and a technical powertrain setup that fits its executive mission.
The main trade-offs are clear: the design may not appeal to everyone, and the price is high. The expert notes also flag the cost as a drawback, even though the car delivers a lot of luxury and capability for buyers who want a top-tier sedan.
Buy now if: you want a flagship luxury sedan that prioritizes comfort, technology, and a premium feel over value shopping.
The market looks reasonably open, with 34.5% of listings marked as good or great deals.
Is the 2022 Mercedes-Benz S-Class reliable?
Owners rate it 4.5/5, a strong signal of long-term satisfaction.
The S-Class is built around Mercedes-Benz’s flagship formula: advanced engineering, a refined ride, and a strong emphasis on comfort and technology. The expert notes also describe the powertrain as seamless and responsive, which supports the impression of a well-sorted luxury sedan rather than a finicky one.
The performance content highlights the EQ Boost system as a seamless source of extra power and torque, which suggests a sophisticated setup rather than a strained one. The cost-effectiveness notes also say buyers who choose the sedan 4Matic will find little to complain about or regret.
For used buyers, the main long-term ownership risk is less about basic competence and more about the complexity and cost that can come with a highly equipped flagship luxury car.
What should I look for when buying a used 2022 Mercedes-Benz S-Class?
Accident-free inventory is solid at 86.5% — always verify the vehicle history report.
You should still check the history report carefully, because a clean listing percentage does not replace a proper records review. Prioritize a pre-purchase inspection that focuses on electronics, suspension behavior, and any signs of expensive wear on a high-end luxury sedan. Pay close attention to overall condition, since this model’s appeal depends heavily on how well the cabin, tech, and ride quality have been preserved.
Key things to evaluate:
- Trim level: The S500 and S580 both bring a high-end experience, but the base Luxury Line is the entry point, while AMG Line and Executive Line add more equipment and presence. The cabin’s standout features include the 12.8-inch touchscreen, 12.3-inch digital instrument panel, and premium materials throughout.
- Powertrain: The S500 uses a turbocharged 3.0-liter inline-six mild-hybrid setup, while the S580 uses a twin-turbo 4.0-liter V8. Both use EQ Boost, a nine-speed automatic transmission, and standard 4Matic AWD, with the S500 rated at up to 21 mpg city/30 mpg highway/24 mpg combined and the S580 at 16 mpg city/25 mpg highway/19 mpg combined.
- Safety package: Standard driver assistance includes active distance assist Distronic, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic and turn-off functions, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication. Available rear-passenger airbags and rear-seat belt bag add executive-focused protection.
- Infotainment: The S-Class uses a 12.8-inch OLED touchscreen with the latest MBUX system, plus a 12.3-inch digital instrument panel. It also includes standard augmented video for navigation, with an available augmented reality head-up display and standard Burmester 3D Surround sound.
- Fuel efficiency: The S500 is rated at up to 21 mpg city, 30 mpg highway, and 24 mpg combined, while the S580 is rated at 16 mpg city, 25 mpg highway, and 19 mpg combined.
Which 2022 Mercedes-Benz S-Class trim should I buy?
The 2022 Mercedes-Benz S-Class is offered in 5 trim levels: S500 4Matic Sedan Luxury Line, S500 4Matic Sedan AMG Line, S580 4Matic Sedan Luxury Line, S580 4Matic Sedan AMG Line, and S580 4Matic Sedan Executive Line.
Here's the short version:
- S500 4Matic Sedan Luxury Line: This is the entry point and the most accessible way into the S-Class experience, pairing the six-cylinder mild-hybrid setup with standard all-wheel drive and the flagship cabin tech. It makes the most sense if you want the core S-Class formula without stretching for extra appearance or executive upgrades.
- S500 4Matic Sedan AMG Line: This adds a sportier visual presentation and is the version to consider if you want a more aggressive look while staying with the S500 powertrain. It suits you if style matters as much as the standard luxury content.
- S580 4Matic Sedan Luxury Line: This is the best-value upgrade if you want the V8’s extra performance and still prefer a restrained luxury presentation. It gives you the strongest blend of power and traditional flagship comfort.
- S580 4Matic Sedan AMG Line: Choose this if you want the V8 plus a more assertive appearance package. It’s for buyers who want the stronger engine and a more expressive look.
- S580 4Matic Sedan Executive Line: This is the top-end choice for buyers who want the most upscale, chauffeur-friendly version of the lineup. It’s the one to target if rear-seat comfort and prestige matter most.
The safety package is extensive across the lineup, with executive-level rear-seat protection available on higher-spec versions.
Is now a good time to buy a used 2022 Mercedes-Benz S-Class?
This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.
- Deal availability: 34.5% of listings are priced as good or great deals.
- Inventory: There are 1,130 listings available.
- Price trend: Prices have softened 10.47% compared with last year.
- Clean inventory: 86.5% of listings are accident-free.
If you find a listing below $63,170, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2022 Mercedes-Benz S-Class's resale value?
The current average of $63,211 sits slightly below last year's $70,601.
That decline suggests the market has already adjusted downward, which can help you as a buyer but may pressure future resale if you plan to sell soon. For a future seller, the key takeaway is that the model’s value is still supported by its flagship status, but pricing momentum has softened.
If you buy well and keep the car in strong condition, you may be better positioned than the average seller when it’s time to move on. High-end luxury sedans can hold demand when they remain desirable, well maintained, and properly equipped.
Vehicles with strong owner satisfaction ratings, like this model year's 4.5/5, tend to retain buyer demand, which supports resale value over time.
Is the 2022 Mercedes-Benz S-Class safe?
The 2022 Mercedes-Benz S-Class earns a 9/10 safety score from our experts.
Mercedes-Benz loads the S-Class with a broad suite of standard and available driver assistance features, including active distance assist Distronic, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic and turn-off functions, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication.
Magic Vision Control is standard, and the car also offers executive-focused rear-seat safety features such as available rear-passenger airbags and a rear-seat belt bag. The main caveat is that some of the most advanced protection and comfort features are reserved for higher-spec or available configurations.
Should I buy a 2022 Mercedes-Benz S-Class or consider a different year?
If you're weighing the 2022 against nearby model years, here's how to think about it:
Choose the 2022 if:
- 34.5% of listings are priced as good or great deals.
- Accident-free inventory is solid at 86.5% — always verify the vehicle history report.
- Price trend: Prices have softened 10.47% compared with last year.
- Owners rate it 4.5/5 — a strong satisfaction signal.
- It combines flagship comfort, advanced tech, and a polished ride in a freshly redesigned generation.
Consider the 2021 if:
- At $58,597, the 2021 costs less than the current year's $63,211 average.
- It launched the redesigned S-Class with new powertrains and advanced tech.
Consider the 2023 if:
- At $78,507, the 2023 costs more than the current year's $63,211 average.
- It adds a new plug-in hybrid powertrain with electric driving capability.
The bottom line: If you want the best balance of price, freshness, and flagship appeal, the 2022 is the sweet spot. If your priority is saving money, the 2021 is the better value play. If you want the newer powertrain and can justify the higher price, the 2023 is the upgrade path.
These recommendations are based on CarGurus' proprietary market data from September 29, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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