Used 2022 Mercedes-Benz GLS for Sale nearCincinnati, OH

How much does the 2022 Mercedes-Benz GLS cost?

Prices have softened 14.99% compared to this time last year, making it a favorable time to shop this model year.

There are 853 listings available, which gives you a decent amount of inventory to compare before you buy.

Is the 2022 Mercedes-Benz GLS a good car?

Yes — you’re looking at a 5/5 user-rated SUV with an expert score of 7.33/10. The 2022 GLS sits at the top of Mercedes’ luxury SUV range, and it’s positioned as the brand’s biggest SUV, so it’s aimed at you if you want a full-size luxury statement with real utility. The standout strength is Look and feel at 9/10.

The GLS 450’s strengths are clear: stylish design, a powerful engine, and a spacious cabin. The trade-offs are just as important, though, because the expert notes poor ride quality and poor ergonomic design, and advanced safety features are not standard.

For shoppers who want a large, upscale SUV with a strong presence and plenty of room, the GLS fits the brief well. 33.2% of listings are priced as good or great deals, so there’s some room to shop selectively.

Is the 2022 Mercedes-Benz GLS reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction. The GLS is presented as a flagship luxury SUV with a strong emphasis on comfort, space, and upscale presentation, and the expert review also highlights a smooth inline-six powertrain with mild-hybrid assistance. That combination points to a vehicle that should feel substantial and refined in daily use.

The performance notes also support confidence in the drivetrain: the 3.0-liter turbocharged inline-six and EQ Boost system are described as providing more than enough muscle, with the electric assist blended in nicely. Mercedes also says the electric motor powers most accessories, which helps reduce engine workload.

Mercedes includes a four-year, 50,000-mile basic warranty and a four-year, 50,000-mile powertrain warranty, and the GLS 450 comes fairly well-equipped for the money. For used buyers, the main long-term risk is that some desirable comfort and driver-assistance features were optional, so you’ll want to verify the exact equipment on the specific vehicle you’re considering.

What should I look for when buying a used 2022 Mercedes-Benz GLS?

Accident-free inventory is solid at 87.1% — always verify the vehicle history report.

You should still run a history report on any GLS you’re considering, even if the listing looks clean. Prioritize a pre-purchase inspection that checks the suspension, electronics, and interior controls, since this is a large luxury SUV with a lot of systems to evaluate. Focus on condition and equipment content, because some of the most desirable features were not standard.

Key things to evaluate:

• Trim level: In base GLS 450 form, the cabin is more subtle and less flashy than some rivals, and the test car had a fairly basic interior by GLS standards. It still felt properly luxurious with leather upholstery, a panoramic roof, ambient lighting, and a high-quality overall presentation, but it did not have reclining seats.
• Powertrain: The GLS 450 uses a 3.0-liter turbocharged inline six-cylinder engine with a nine-speed automatic and EQ Boost mild-hybrid assistance. It makes 362 horsepower and 369 pound-feet of torque, with an additional 21 hp and 184 lb-ft available in short bursts.
• Safety package: Standard safety features include forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. Adaptive cruise control, lane-keep assist, second-row side airbags, and more advanced driver-assistance features are extra.
• Infotainment: The standard MBUX setup includes a 12.3-inch touchscreen, a 12.3-inch digital instrument cluster, Bluetooth, Apple CarPlay/Android Auto, navigation, SiriusXM satellite radio, and natural-language voice recognition. A 13-speaker Burmester audio system is standard, and a head-up display is optional.
• Fuel efficiency: EPA fuel economy is 20 mpg combined, 18 mpg city, and 24 mpg highway.

Which 2022 Mercedes-Benz GLS trim should I buy?

The 2022 Mercedes-Benz GLS is offered in 1 trim level: GLS 450 4Matic.

Here's the short version:

The GLS 450 4Matic is the only version available for this model year, so your decision is less about trim shopping and more about finding the right example. It gives you the core GLS experience: a smooth inline-six, standard AWD, air suspension, a surround-view camera system, and a well-appointed luxury cabin. It’s the best fit if you want the flagship GLS formula without waiting for higher-output variants to return.

Mercedes does leave some important safety and convenience features off the standard equipment list, including adaptive cruise control and lane-keep assist, so check the option content carefully before you buy.

Is now a good time to buy a used 2022 Mercedes-Benz GLS?

This looks like a moderate, selective buyer’s market, so you can shop with some leverage if you’re patient.

• Deal availability: 33.2% of listings are priced as good or great deals.
• Inventory: There are 853 listings available.
• Price trend: Prices have softened 14.99% compared with last year.
• Clean inventory: 87.1% of listings are accident-free.

If you find a listing below $47,197, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz GLS's resale value?

The current average of $47,197 sits slightly below last year's $55,520.

That price movement suggests the market has cooled, which can work in your favor as a buyer but may pressure future resale values if you sell too soon. For a future seller, the current trend means you may need to price competitively to stand out, especially if similar listings remain plentiful. Well-equipped examples with strong condition and desirable options should still draw attention from shoppers looking for a flagship luxury SUV.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz GLS safe?

The 2022 Mercedes-Benz GLS does not have published IIHS or NHTSA crash-test ratings in the available data.

It earns a 6/10 safety score from our experts.

Standard safety features include forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. Mercedes also notes that some advanced driver-assistance features are optional rather than standard, including adaptive cruise control, lane-keep assist, Active Steering Assist, Evasive Steering Assist, Active Lane Change Assist, Active Blind Spot Assist, and Active Emergency Stop Assist.

That means you should verify the exact safety equipment on any used example, because the base vehicle leaves some important assistance tech on the table.

Should I buy a 2022 Mercedes-Benz GLS or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 33.2% of listings are priced as good or great deals.
• Accident-free inventory is solid at 87.1% — always verify the vehicle history report.
• Price trend: Prices have softened 14.99% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• The 2022 stands out as the only GLS version available at the time of testing, with a strong engine and spacious cabin.

Consider the 2021 if:

• At $46,775, the 2021 costs less than the current year's $47,197 average.
• It emphasizes comfort and upscale presentation with three rows of spacious seating.

The bottom line: If you want the current-year GLS at a softened price and you value the specific 2022 setup, this is the cleaner path. If you’re mainly trying to save a little money, the 2021 is worth a look, especially if you find one with the equipment and condition you want.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.