Used 2022 Mercedes-Benz E-Class for Sale nearSan Francisco, CA

Compare 2022 Mercedes-Benz E-Class Trims in San Francisco, CA

The E-Class offers a blend of luxury and performance, with options ranging from budget-friendly to high-performance models.

• Starting at $29,524
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 RWD

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want luxury features without paying for higher trims. It's also the most popular choice in the lineup.

• Avg. market price: $29,524 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 85 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is ideal for those who want all-wheel drive without a significant price increase. It balances performance and comfort well.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 64 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is for buyers seeking a powerful engine and luxury features in an all-wheel-drive package.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 20 listings
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without going for the higher-priced trims.

• Avg. market price: $38,835 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 22 listings
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for shoppers wanting a luxury coupe with all-wheel drive and premium features.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 11 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is ideal for those who want a luxurious convertible experience without stepping up to the AMG models.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 13 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Sedan 4MATIC — "Who It's For"

The AMG E 53 Sedan 4MATIC is for performance enthusiasts who want a powerful engine and advanced features in a luxury sedan.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 11 listings — lower availability; may limit negotiating room
• View AMG E 53 Sedan 4MATIC listings

AMG E 53 Coupe 4MATIC — "Who It's For"

The AMG E 53 Coupe 4MATIC is perfect for buyers seeking a sporty coupe with high performance and luxury features.

• Avg. market price: $34,179 (updated weekly)
• MPG/MPGe: 20 city / 28 hwy
• Inventory: 5 listings — lower availability; may limit negotiating room
• View AMG E 53 Coupe 4MATIC listings

Trim Recommendations

Most Popular — E 350 RWD

With 85 active listings, the E 350 RWD is the clear volume leader in the lineup.

Browse E 350 RWD listings

Best Budget Option — E 350 RWD

At $29,524 avg market price — below the lineup median of $34,179 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 350 RWD

The E 350 RWD offers the best fuel economy in the lineup at 23/31 MPG.

Browse E 350 RWD listings

These recommendations are based on CarGurus' proprietary market data from October 29, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz E-Class cost?

Prices have softened 7.21% compared to this time last year, making it a favorable time to shop this model year.

There are 1,195 listings available, which gives you a solid amount of inventory to compare.

Is the 2022 Mercedes-Benz E-Class a good car?

Yes — the 2022 Mercedes-Benz E-Class earns a 5/5 user rating and an 8.2/10 expert rating. The standout strength is Safety at 10/10.

The E-Class stands out for offering a rare kind of luxury in a class of one, especially in Cabriolet form. It also leans on established strengths after a substantial refresh for the prior model year, so you’re shopping a polished luxury car rather than a major redesign. For buyers who want a premium experience with useful updates, that’s a strong formula.

The market also shows 37.7% good or great deals, which suggests there are worthwhile opportunities if you shop carefully.

Is the 2022 Mercedes-Benz E-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The 2022 E-Class builds on a substantial refresh and keeps the lineup focused on turbocharged four-cylinder and six-cylinder power plants. The expert test drive data also points to a car that feels refined, with a luxe interior, strong technology, and a broad range of body styles and configurations. Its EQ Boost mild-hybrid setup is described as improving both power output and efficiency, which supports the impression of a well-engineered powertrain.

If you buy used, long-term ownership risk is mostly about choosing a well-kept example with the right equipment and maintenance history.

What should I look for when buying a used 2022 Mercedes-Benz E-Class?

Accident-free inventory is solid at 84.9% — always verify the vehicle history report.

You should still run a history report on any car you’re considering, even if the listing looks clean. Prioritize a pre-purchase inspection that checks the convertible top, electronics, and any wear from luxury features that can be expensive to sort out later. Focus on condition, equipment operation, and whether the car has the options you actually want.

Key things to evaluate:

• Trim level: The lineup spans coupe, convertible, sedan, and station wagon body styles, and the E-Class can be configured from a more understated E350 sedan to an E450 with a turbo 3.0-liter inline-six and EQ Boost mild-hybrid technology. The AMG E53 adds a more powerful version of that engine, AMG styling, and a more performance-focused character, while the base E350 is the least expensive way in.
• Powertrain: You’ll find a turbocharged four-cylinder in the E350 and a turbo 3.0-liter inline-six with EQ Boost in the E450, while AMG E53 models use a more powerful version of the six-cylinder. The performance setup is described as robust, with strong response across the rev range and an AMG Speedshift nine-speed automatic in AMG versions.
• Safety package: Standard equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Driver Assistance Package adds adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus.
• Infotainment: The E-Class uses MBUX with two 12.3-inch screens, including a touchscreen and digital instrument cluster. It supports Apple CarPlay and Android Auto, and it also offers WiFi service and an augmented reality navigation overlay.
• Fuel efficiency: The E450 convertible is described as a way to save money versus a loaded AMG model while still getting robust acceleration and the MBUX system, but no MPG figure is stated.

Which 2022 Mercedes-Benz E-Class trim should I buy?

The 2022 Mercedes-Benz E-Class is offered in 3 trim levels: E350, E450, and AMG E53.

Here's the short version:

• E350: This is the entry point if you want the E-Class experience with the turbocharged four-cylinder engine and the most accessible price. It makes the most sense if you care more about luxury, style, and everyday comfort than maximum performance.
• E450: This is the best-value choice for many shoppers because it adds the turbo 3.0-liter inline-six with EQ Boost mild-hybrid technology while keeping the E-Class’s upscale feel and broad appeal. If you want stronger performance without jumping to AMG pricing, this is the trim to target.
• AMG E53: Choose this if you want the most performance-focused version in the lineup, with the more powerful six-cylinder setup, AMG tuning, and a more aggressive driving character. It suits you best if driving enjoyment matters more than value.

The Driver Assistance Package is the key safety add-on to look for, since many advanced driver aids are bundled there.

Is now a good time to buy a used 2022 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, with enough inventory and pricing movement to reward careful shopping.

• Deal availability: 37.7% of listings are priced as good or great deals.
• Inventory: There are 1,195 listings available.
• Price trend: Prices have softened 7.21% compared with last year.
• Clean inventory: 84.9% of listings are accident-free.

If you find a listing below $38,963, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz E-Class's resale value?

The current average of $39,004 sits slightly below last year's $42,033.

That decline suggests the market has softened, which can help you buy at a better entry point today. For a future seller, it also means you should pay close attention to purchase price, because starting lower gives you more room to preserve value later. Well-equipped examples with strong condition and desirable options should be easier to move than stripped or neglected ones.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz E-Class safe?

The 2022 Mercedes-Benz E-Class earns a 10/10 safety score from our experts.

It has standard forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, and rear cross-traffic alert. Mercedes Pre Safe and Pre Safe Sound are also standard, and the Cabriolet adds pop-up rollbars for rollover protection. The Driver Assistance Package brings adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus.

Should I buy a 2022 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 37.7% of listings are priced as good or great deals.
• Accident-free inventory is solid at 84.9% — always verify the vehicle history report.
• Price trend: Prices have softened 7.21% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• The 2022 lineup drops the AMG E63 and E63 S, but keeps turbocharged four-cylinder and six-cylinder power with useful standard updates.

Consider the 2021 if:

• At $35,986, the 2021 costs less than the current year's $39,004 average.
• It offers four body styles, four engines, and broad configurability.

The bottom line: If you want the better current-market value and the updated 2022 lineup, this year is the smarter default choice. If your priority is spending less upfront, the 2021 is the better path, especially if you find one with the equipment and condition you want.

How does the 2022 Mercedes-Benz E-Class compare to the 2022 BMW 5 Series?

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from October 27, 2026, CarGurus experts' opinions, and generative AI.