Used 2022 Lexus RX for Sale near Missouri

How much does the 2022 Lexus RX cost?

Prices have softened 4.14% compared to this time last year, making it a favorable time to shop this model year.

There are 2,187 listings available, which suggests solid inventory for shoppers comparing trims and prices.

Is the 2022 Lexus RX a good car?

Yes — the 2022 Lexus RX earns a 4.77/5 user rating and a 7.33/10 expert rating. The model scores 8/10 across Cost effectiveness and Safety.

Owners consistently praise its comfortable cabin, smooth ride, luxury feel, and feature-rich feel, and they also highlight its advanced tech. For buyers who want a relaxed, upscale SUV rather than a sporty one, that lines up well with the RX’s comfort-first character. The main trade-offs are its lack of pickup power and some concerns about gas mileage, along with a design and ergonomics package that may not suit everyone. Even so, it fits well if you want a premium daily driver with a calm, refined personality. Good and great deals account for 36.9% of listings, which gives you room to shop selectively.

Is the 2022 Lexus RX reliable?

Owners rate it 4.77/5, a strong signal of long-term satisfaction.

The owner feedback points to a vehicle that feels comfortable, dependable, and easy to live with over time, with repeated praise for its smooth, trouble-free character and luxury feel. The expert evaluation also emphasizes Lexus’ reputation for reliability and notes that the RX remains a familiar, proven formula rather than a risky redesign. On the ownership side, that usually means less uncertainty than you might face with a newer or more experimental luxury SUV, though you should still verify maintenance history and condition carefully on any used example.

What should I look for when buying a used 2022 Lexus RX?

Accident-free inventory is solid at 82.8% — always verify the vehicle history report.

You should still check the vehicle history report carefully, because accident-free listings are not the same as guaranteed problem-free ownership. Prioritize a pre-purchase inspection that focuses on wear, electronics, and how well the cabin and controls have held up. Since this model is comfort- and feature-oriented, pay close attention to seat condition, infotainment operation, and whether the vehicle’s equipment matches the trim you’re considering.

Key things to evaluate:

• Trim level: The gas model comes in 3 trim levels: base 350, F Sport, and L. The base and L trims share the more restrained exterior treatment, while F Sport adds 20-inch wheels, black-housing mirrors, dark window trim, F Sport badging, and a unique front fascia. The L trim is the three-row, 7-passenger option, so it suits you if you need extra seating.
• Powertrain: The RX 350 uses a 3.5-liter V6 with 295 horsepower and 267 pound-feet of torque, paired with an eight-speed automatic. Front-wheel drive is standard on the RX 350, with all-wheel drive available. The hybrid RX 450h adds two electric motors and produces 308 hp, but that is a separate hybrid model.
• Safety package: Lexus Safety System 2.0+ is standard and includes adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Blind-spot monitoring, rear cross-traffic alert, a head-up display, and Lexus Enform Safety Connect are also standard. The Top Safety Pick result depends on the optional triple-beam LED headlights.
• Infotainment: Standard infotainment uses an 8-inch touchscreen, with a 12.3-inch screen available. Android Auto and Apple CarPlay are included, along with wireless charging, Amazon Alexa compatibility, a WiFi hotspot, and navigation with cloud-based updates.
• Fuel efficiency: The RX 350 returns 20 mpg city, 27 mpg highway, and 23 combined. With AWD or the three-row L model, those figures drop by 1 mpg. The RX 450h hybrid is rated at 30 mpg combined, with 31 mpg city and 28 mpg highway.

Which 2022 Lexus RX trim should I buy?

The 2022 Lexus RX is offered in 3 trim levels: base 350, F Sport, and L.

Here's the short version:

• 350: This is the best-value choice if you want the RX’s core strengths without paying for extra styling or seating. It gives you the standard V6, the full safety suite, and the comfort-focused character that defines the model.
• F Sport: Choose this if you want the most aggressive appearance and the sportiest equipment list, including the larger wheels and F Sport-specific exterior and interior details. It is the right pick if style matters more to you than a softer, more traditional luxury look.
• L: Pick this if you need the three-row, 7-passenger layout. It is the trim that expands the RX’s usefulness for families or anyone who wants extra seating.

The safety package is standard, but the Top Safety Pick result depends on the optional triple-beam LED headlights.

Is now a good time to buy a used 2022 Lexus RX?

This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.

• Deal availability: 36.9% of listings are priced as good or great deals.
• Inventory: There are 2,187 listings available.
• Price trend: Prices have softened 4.14% compared with last year.
• Clean inventory: 82.8% of listings are accident-free.

If you find a listing below $39,336, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Lexus RX's resale value?

The current average of $39,362 sits slightly below last year's $41,063.

That price movement suggests the RX has softened enough to help you buy more selectively now, but it also means future sellers may face some pressure if the market stays soft. The relatively narrow year-round range points to a model with fairly stable pricing behavior, which can help limit volatility. If you buy well today and keep the vehicle in strong condition, you should be in a better position when it is time to sell.

Vehicles with strong owner satisfaction ratings, like this model year's 4.77/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Lexus RX safe?

The 2022 Lexus RX earns a Top Safety Pick rating from IIHS when equipped with the optional triple-beam LED headlights, and it earns four-star ratings overall from NHTSA, with five-star ratings in side crash tests and four-star ratings in frontal crash and rollover resistance.

It earns an 8/10 safety score from our experts.

Lexus Safety System 2.0+ is standard, and it brings adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Standard blind-spot monitoring, rear cross-traffic alert, a head-up display, and Safety Connect add more everyday protection. The main caveat is that the IIHS top-tier designation depends on the optional headlights, so you should confirm that equipment if safety is a priority.

Should I buy a 2022 Lexus RX or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 36.9% of listings are priced as good or great deals.
• Accident-free inventory is solid at 82.8% — always verify the vehicle history report.
• Price trend: Prices have softened 4.14% compared with last year.
• Owners rate it 4.77/5 — a strong satisfaction signal.
• It keeps the familiar comfort-first formula with minimal changes and added fog lamps availability.

Consider the 2021 if:

• At $35,559, the 2021 costs less than the current year's $39,362 average.
• It emphasizes comfort, value, and reliability with a familiar, mostly unchanged formula.

Consider the 2023 if:

• At $46,013, the 2023 costs more than the current year's $39,362 average.
• It brings a redesigned, more modern take with stronger technology and a fresher feel.

The bottom line: If you want the best balance of price, proven reliability, and available inventory, the 2022 is the sensible default. If your budget is tighter, the 2021 is the better value play. If you want the newer redesign and are willing to pay more, the 2023 is the upgrade path.

These recommendations are based on CarGurus' proprietary market data from September 15, 2026, CarGurus experts' opinions, and generative AI.