Used 2022 Lexus RX for Sale near Missouri

How much does the 2022 Lexus RX cost?

Prices have softened 6.24% compared to this time last year, making it a favorable time to shop this model year.

There are 1,924 listings available, which suggests you should have a reasonable amount of inventory to compare.

Is the 2022 Lexus RX a good car?

Yes — the 2022 Lexus RX earns a 4.8/5 user rating and a 7.3/10 expert rating. The model scores 8/10 across Cost effectiveness and Safety.

Owners consistently praise its smooth ride, comfort, luxury feel, and loaded feature set. The expert review also points to strong ride quality and a premium driving experience, while noting that the RX is aimed more at refinement than excitement.

The main trade-offs are its potentially polarizing design and poor ergonomic design, along with limited performance for shoppers who want something more responsive. For you, that means the RX makes the most sense if you want a comfortable, upscale SUV rather than a sporty one.

The market also looks reasonably healthy, with 37.7% of listings marked as good or great deals.

Is the 2022 Lexus RX reliable?

Owners rate it 4.8/5, a strong signal of long-term satisfaction.

User feedback highlights the RX as comfortable, trouble-free in spirit, and easy to live with, with many owners emphasizing its dependable feel and strong long-term appeal. The expert review also reinforces that reputation by describing Lexus’ tradition of reliability and the RX’s comfort-focused, durable character.

The cost-effectiveness review adds that the RX gives you the comfort, quality, and reliability many shoppers want from the brand. For used buyers, the main long-term ownership risk is less about dependability and more about whether the vehicle’s age, ergonomics, and performance match your expectations.

What should I look for when buying a used 2022 Lexus RX?

Accident-free inventory is solid at 78.8% — always verify the vehicle history report.

You should still check the vehicle history report carefully, because accident-free status does not replace a full records review. A pre-purchase inspection should focus on cabin ergonomics, infotainment usability, and whether the vehicle’s condition matches the mileage and asking price. If you’re considering a higher-trim example, make sure the added equipment is actually present and functioning as expected.

Key things to evaluate:

• Trim level: The gas model is offered in base 350, F Sport, and L trim levels, with the base and L variants emphasizing comfort and the F Sport adding a more athletic look. The base and L trims use 18-inch wheels and standard exterior lighting, while F Sport models add 20-inch wheels, black-housing mirrors, dark window trim, F Sport badging, and a unique front fascia.
• Powertrain: The RX 350 uses a 3.5-liter V6 with 295 horsepower and an eight-speed automatic transmission. Front-wheel drive is standard, all-wheel drive is available, and the hybrid RX 450h adds electric motors for more output and better efficiency.
• Safety package: Lexus Safety System 2.0+ is standard and includes adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Blind-spot monitoring, rear cross-traffic alert, a head-up display, and Lexus Enform Safety Connect are also standard, though the IIHS top-tier designation requires optional triple-beam LED headlights.
• Infotainment: Standard infotainment uses an 8-inch touchscreen, with a 12.3-inch screen available. Android Auto and Apple CarPlay are included, along with wireless charging, Amazon Alexa compatibility, a WiFi hotspot, navigation with cloud-based updates, and multiple premium audio options.
• Fuel efficiency: The RX 350 returns 20 mpg city and 27 mpg highway, while the hybrid RX 450h is rated at 31 mpg city and 28 mpg highway.

Which 2022 Lexus RX trim should I buy?

The 2022 Lexus RX is offered in 3 trim levels: base 350, F Sport, and L.

Here's the short version:

• 350: This is the trim to start with if you want the core RX experience, including the V6 powertrain, standard safety tech, and the comfort-focused ride that defines the model. It gives you the best balance of price and everyday luxury, making it the best-value choice for most shoppers.
• F Sport: Choose this if you want the most aggressive styling and the sportiest appearance in the lineup. It adds 20-inch wheels, unique exterior details, and performance-oriented touches, but the review makes clear that it does not transform the RX into a genuinely sporty SUV.
• L: Pick this if you need the three-row, 7-passenger layout. It is the right choice when passenger flexibility matters more than the sharper styling of the F Sport.

The standard safety package is strong across the lineup, but the IIHS top rating depends on the optional triple-beam LED headlights.

Is now a good time to buy a used 2022 Lexus RX?

This looks like a moderate, selective buyer’s market, so you can shop patiently but should move quickly on strong listings.

• Deal availability: 37.7% of listings are priced as good or great deals.
• Inventory: There are 1,924 listings available.
• Price trend: Prices have softened 6.24% compared with last year.
• Clean inventory: 78.8% of listings are accident-free.

If you find a listing below $37,945, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Lexus RX's resale value?

The current average of $37,945 sits slightly below last year's $40,472.

That decline suggests the RX has become more affordable for used buyers, which can help keep demand steady in the near term. For a future seller, the current pricing trend means you may not see the same resale strength that came with last year’s higher average. Even so, the RX’s broad appeal and strong reputation should help support values better than many rivals.

Vehicles with strong owner satisfaction ratings, like this model year's 4.8/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Lexus RX safe?

The 2022 Lexus RX earns a Top Safety Pick rating from the Insurance Institute for Highway Safety when equipped with the optional triple-beam LED headlights, and it earns four-star ratings overall from NHTSA, with five-star ratings in side crash tests and four-star ratings in frontal crash and rollover resistance.

It earns an 8/10 safety score from our experts.

Lexus Safety System 2.0+ is standard, and it includes adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Standard safety equipment also includes blind-spot monitoring, rear cross-traffic alert, a head-up display, and Lexus Enform Safety Connect.

The main caveat is that the RX misses the IIHS top-tier designation unless you get the optional triple-beam LED headlights. That means safety is strong overall, but you should pay attention to headlight equipment when comparing used listings.

Should I buy a 2022 Lexus RX or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 37.7% of listings are priced as good or great deals.
• Accident-free inventory is solid at 78.8% — always verify the vehicle history report.
• Price trend: Prices have softened 6.24% compared with last year.
• Owners rate it 4.8/5 — a strong satisfaction signal.
• It’s a carryover year with minimal changes, including new colors and a standalone fog lamps option.

Consider the 2021 if:

• At $34,905, the 2021 costs less than the current year's $37,945 average.
• It offers similar comfort and reliability with a slightly lower entry price.

Consider the 2023 if:

• At $44,564, the 2023 costs more than the current year's $37,945 average.
• It brings a redesigned cabin and more modern technology.

The bottom line: If you want the current-year RX at a softer price, the 2022 is the sensible pick. If your priority is saving money, the 2021 is the better value. If you want the newest design and tech, the 2023 is the upgrade path.

How does the 2022 Lexus RX compare to the 2022 Toyota Venza?

Expert Pros & Cons (per CarGurus review team)

2022 Lexus RX:

• Pros: Great ride quality, Standard advanced safety features.
• Cons: Potentially polarizing design, Poor ergonomic design.

2022 Toyota Venza:

• Pros: Fuel-efficient, Standard all-wheel drive, Standard advanced safety features.
• Cons: Unintuitive technology, Potentially polarizing design.

Our experts score the 2022 Lexus RX 7.3/10 and the 2022 Toyota Venza 8.5/10. The RX is the better choice if you care most about ride quality and a more traditional luxury feel. The Venza stands out for fuel efficiency and standard all-wheel drive, which makes it the more practical pick for many shoppers. If you want a more upscale, comfort-first SUV, the RX has the edge; if efficiency matters more, the Venza is the stronger value.

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.