Used 2022 Lexus RX for Sale near Saint Louis, MO

119 results

Saint Louis, MO

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2023 Lexus RX

350 AWD

34,984 miles

$45,990

Fair Deal

Ballwin, MO

19 mi away

Year:: 2023
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 275 hp 2.4L I4
Combined gas mileage:: 24 MPG
Fuel type:: Gasoline
Transmission:: Automatic
Mileage:: 34,984
Stock number:: 7759551
VIN:: 2T2BAMCA1PC037121

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2021 Lexus RX

350 FWD

32,572 miles

$38,756

Fair Deal

Herculaneum, MO

28 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Eminent White Pearl
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 32,572
Stock number:: A86378
VIN:: 2T2HZMAA8MC184358

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2022 Lexus RX

350 AWD

32,641 miles

$38,496

Good Deal

Chesterfield, MO

25 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Green
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: Automatic
Mileage:: 32,641
Stock number:: YNC34459
VIN:: 2T2AZMDA9NC344598

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2021 Lexus RX

350 FWD

65,090 miles

$33,497

Good Deal

Store transfer to Saint Louis, MO

1,549 mi away Price includes $1,499 shipping Price includes $1,499 shipping

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Gray
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Gray
Transmission:: Automatic
Mileage:: 65,090
Stock number:: 27808782
VIN:: 2T2HZMAA3MC186471

2022 Lexus RX

350L FWD

26,779 miles

$42,397

Good Deal

Store transfer to Saint Louis, MO

1,601 mi away Price includes $1,399 shipping Price includes $1,399 shipping

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 290 hp 3.5L V6
Exterior color:: Black
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: CREAM
Transmission:: Automatic
Mileage:: 26,779
Stock number:: 28146572
VIN:: JTJHZKEA8N2029048

2022 Lexus RX

350 AWD

32,641 miles

$38,496

Good Deal

Chesterfield, MO

25 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Green
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: Automatic
Mileage:: 32,641
Stock number:: YNC34459
VIN:: 2T2AZMDA9NC344598

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2022 Lexus RX

350L AWD

49,285 miles

$37,766

Good Deal

St Louis, MO

11 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 290 hp 3.5L V6
Exterior color:: Nebula Gray Pearl
Combined gas mileage:: 21 MPG
Fuel type:: Gasoline
Interior color:: Black Leather
Transmission:: Automatic
Mileage:: 49,285
Stock number:: L25189A
VIN:: JTJHZKFA7N2042808

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2021 Lexus RX

350 F Sport AWD

58,647 miles

$36,455

Good Deal

Manchester, MO

15 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Nebula Gray Pearl
Combined gas mileage:: 22 MPG
Fuel type:: Gasoline
Interior color:: Circuit Red
Transmission:: 8-Speed Automatic
Mileage:: 58,647
Stock number:: 12453R
VIN:: 2T2SZMDA2MC272680

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2022 Lexus RX

350L AWD

75,007 miles

$34,794

Good Deal

O Fallon, MO

28 mi away

Year:: 2022
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 290 hp 3.5L V6
Exterior color:: Gray
Combined gas mileage:: 21 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: Automatic
Mileage:: 75,007
Stock number:: PX10250
VIN:: JTJHZKFA7N2035972

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2023 Lexus RX

350 Premium AWD

14,938 miles

$48,700

Fair Deal

Saint Peters, MO

24 mi away

Year:: 2023
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 275 hp 2.4L I4
Exterior color:: Red (Copper Crest)
Combined gas mileage:: 24 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 14,938
Stock number:: MP16972
VIN:: 2T2BAMCA4PC011550

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2021 Lexus RX

350 FWD

32,572 miles

$38,756

Fair Deal

Herculaneum, MO

28 mi away

Year:: 2021
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: Front-Wheel Drive
Engine:: 295 hp 3.5L V6
Exterior color:: Eminent White Pearl
Combined gas mileage:: 23 MPG
Fuel type:: Gasoline
Interior color:: Black
Transmission:: 8-Speed Automatic
Mileage:: 32,572
Stock number:: A86378
VIN:: 2T2HZMAA8MC184358

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2023 Lexus RX

350 Luxury AWD

52,099 miles

$47,499

Good Deal

Saint Louis, MO

13 mi away

Year:: 2023
Make:: Lexus
Model:: RX
Body type:: SUV / Crossover
Doors:: 4 doors
Drivetrain:: All-Wheel Drive
Engine:: 275 hp 2.4L I4
Combined gas mileage:: 24 MPG
Fuel type:: Gasoline
Transmission:: Automatic
Mileage:: 52,099
Stock number:: PLRS230484
VIN:: 2T2BAMCA4PC003397

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Overview

Reviews

FAQs

CarGurus Analysis: 2022 Lexus RX

Summary

With 2,526 currently listed for sale on CarGurus and an average price of $40,414.60, 35.6% of 2022 Lexus RXs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus RX 4.6 / 5 stars and CarGurus experts gave it an 7.3 / 10.
84.2% of 2022 RX models on CarGurus are accident free.
The 2022 Lexus RX combined a smooth ride quality with standard advanced safety features, solidifying its status as the brand's best-selling model despite its aging design.

Why it stands out

The 2022 Lexus RX stood out for its exceptional ride quality, ensuring a comfortable driving experience that many owners appreciated. It also included standard advanced safety features, reflecting Lexus's commitment to driver and passenger safety. Despite its dated design and some ergonomic considerations, the RX maintained strong sales figures, showcasing its enduring appeal in the luxury SUV market.

Other model years to consider

2020 Lexus RX: This year offers $33,379.27 average price, 33% good/great deals, 4.8/5 user rating, 8.2/10 expert rating, 1,269 listings.
2021 Lexus RX: This year offers $35,773.39 average price, 32% good/great deals, 4.7/5 user rating, 7.8/10 expert rating, 1,829 listings.
2023 Lexus RX: This year offers $47,405.06 average price, 37% good/great deals, 4.6/5 user rating, 7.2/10 expert rating, 3,056 listings.

This analysis is based on CarGurus' proprietary market data from December 16, 2025, CarGurus experts' opinions, and generative AI.

4.6 Overall rating

(24 reviews)

Anonymous

5.0

Reviewed a 2022 Lexus RX on Feb 19, 2024

I just recently purchased a 2022 Lexus RX 350L(2 days actually). Still learning all the many features. Smooth, quiet ride. Great power response. Coming from a 2020 Mercedes GLE 350 I was a bit skeptical if It would measure up. It really does!!

Uday T

4.0

Reviewed a 2022 Lexus RX on Jun 06, 2023

Great car, drives smooth. Lacks pick up power for a V6

Anonymous

5.0

Reviewed a 2022 Lexus 350 AWD on Jun 06, 2023

No unneeded frills but lots of quality of life items. Love the backup camera and surround view, easily the best one out of all the cars we test drove (GMC, Buick, Ford, Nissan). Suspension is solid, corners well, and plenty of power.

Anonymous

4.0

Reviewed a 2022 Lexus 350 FWD on Feb 08, 2023

Car is wonderful except for the gas mileage. Pretty, nice size, comfortable, good safety features.

Anonymous

5.0

Reviewed a 2022 Lexus 350 FWD on Oct 03, 2022

An excellent car which is loaded with features and fun to drive. It is smooth and has a very quiet cabin. Also very luxurious materials in the cabin and fine leather seats,

2022 Lexus RX FAQs

How much does the 2022 Lexus RX cost in Saint Louis, MO?

The average 2022 Lexus RX costs about $39,956.32. The average price has decreased by -4.9% since last year. The 119 for sale near Saint Louis, MO on CarGurus, range from $27,169 to $55,400 in price.

Is the 2022 Lexus RX a good car?

CarGurus experts gave the 2022 Lexus RX an overall rating of 7.3/10 and 2022 Lexus RX owners have rated the vehicle a 4.6/5 stars on average. If a vehicle has both strong expert and owner reviews, you can feel confident in its quality. If either expert reviews, owner reviews, or both are spotty, you might want to do some research to figure out where the car falls short.

How many 2022 Lexus RX vehicles in Saint Louis, MO have no reported accidents or damage?

119 out of 119 for sale near Saint Louis, MO have no reported accidents or damage.

Is the 2022 Lexus RX safe?

CarGurus experts gave the 2022 Lexus RX a safety rating of 8/10.

What is the fuel economy of the 2022 Lexus RX?

Depending on the engine and options, the 2022 Lexus RX gets between 21 and 25 MPG (or EV battery range).

What fuel types are available?

Gasoline engines are available.

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