Used 2021 Mercedes-Benz S-Class for Sale near Riverside, IA

## Summary - With 804 currently listed for sale and an **average price of $60,759.00**, 29.4% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **86.1% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class received a complete overhaul featuring a sophisticated infotainment system, new powertrains, and advanced aerodynamics. ## Why it stands out The 2021 Mercedes-Benz S-Class continues its legacy as a leader in luxury sedans by offering a blend of exquisite design, powerful performance, and cutting-edge technology. It is available in two configurations: the S500 4Matic with a turbocharged inline-six engine producing 429 horsepower and the more powerful S580 4Matic with a V8 engine delivering 496 horsepower. Both models incorporate the EQ Boost mild-hybrid system for enhanced efficiency and performance, achieving zero to 60 mph in as quick as 4.4 seconds. With its stunning design, the S-Class is slightly longer than its predecessor, and it boasts a drag coefficient of just 0.22, contributing to its smooth and refined driving experience. Inside, the cabin showcases an impressive 12.8-inch OLED touchscreen and a highly advanced MBUX infotainment system. The luxurious interior features Nappa leather, ambient lighting, and comfortable seating with multiple adjustments and massage functions. Owners consistently express their satisfaction with the vehicle’s combination of high-tech features, driving performance, and opulent feel. While some users have noted minor drawbacks, like concerns over the run-flat tires, the overall impression is overwhelmingly positive. The 2021 S-Class remains a top choice in the full-size luxury sedan segment, appealing to buyers who prioritize both performance and comfort. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-c31858)** - Average price: $65,943.00 - Good/great deal percentage: 29.1% - User rating: 4.8 / 5 - Total listings: 1,086 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-c24430)** - Average price: $26,068.00 - Good/great deal percentage: 31.3% - User rating: 4.88 / 5 - Total listings: 978 - **[2019 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2019-Mercedes-Benz-S-Class-c28135)** - Average price: $42,547.00 - Good/great deal percentage: 34.5% - User rating: 4.85 / 5 - Total listings: 663 This analysis is based on CarGurus' proprietary market data from March 16, 2026, CarGurus experts' opinions, and generative AI.