Used 2021 Mercedes-Benz S-Class for Sale near Hampton, TN

## Summary - With 811 currently listed for sale and an **average price of $60,777.00**, 32.2% of 2021 Mercedes-Benz S-Class models for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **85.2% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class features a stunning redesign, offering advanced technology, a luxurious feel, and impressive performance metrics, including two powerful engine options, airy interiors, and state-of-the-art infotainment systems. ## Why it stands out The 2021 Mercedes-Benz S-Class continues to define luxury in the full-size sedan category. It boasts significant technological advancements and a modern aesthetic, reinforcing its position as the flagship of the Mercedes lineup. The S-Class combines performance with elegance, offering two potent engine options, the S500's turbocharged inline-six and the S580's twin-turbo V8, which deliver exhilarating acceleration and sophisticated handling. The model also introduces notable features such as the EQ Boost mild-hybrid system, which enhances efficiency without sacrificing power. Upscale interior finishes, spacious seating, and cutting-edge technology elevate the driving experience, making it one of the most desirable luxury sedans. While its high price may deter some buyers, the unparalleled combination of comfort, safety, and performance justify the investment for those seeking an exceptional vehicle. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-c31858)** - Average price: $65,761.00 - Good/great deal percentage: 29.0% - User rating: 4.8 / 5 - Total listings: 1,097 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-c24430)** - Average price: $25,942.00 - Good/great deal percentage: 28.8% - User rating: 4.88 / 5 - Total listings: 970 - **[2014 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2014-Mercedes-Benz-S-Class-c24217)** - Average price: $21,904.00 - Good/great deal percentage: 29.1% - User rating: 4.89 / 5 - Total listings: 794 This analysis is based on CarGurus' proprietary market data from March 20, 2026, CarGurus experts' opinions, and generative AI.