Used 2021 Mercedes-Benz S-Class for Sale near Dothan, AL

## Summary - With 798 currently listed for sale and an **average price of $60,878.00**, 33.3% of 2021 Mercedes-Benz S-Class vehicles for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **84.7% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class features advanced technology, a luxurious interior, and powerful engine options, making it a top choice among full-size luxury sedans. ## Why it stands out The 2021 Mercedes-Benz S-Class is a flagship luxury sedan replete with state-of-the-art technology and refined performance. It maintains its position at the pinnacle of the luxury market by continuously evolving, as demonstrated by its updated powertrains — including the robust S500 4Matic with a 3.0-liter turbocharged inline-six and the S580 4Matic with a V8 engine. Both configurations come standard with 4Matic all-wheel drive and benefit from the EQ Boost mild-hybrid system for enhanced efficiency. Owners rave about the S-Class' superior comfort and impressive tech features, with a modernized infotainment system that includes a 12.8-inch OLED touchscreen and a 12.3-inch digital instrument cluster. The new design has emphasized a minimalist yet opulent interior, featuring 250 LED ambient lights capable of displaying 64 colors—a standard befitting its luxury classification. Despite its luxurious allure, the car has occasionally been critiqued for its run-flat tires. Overall, the 2021 S-Class balances luxury with cutting-edge performance and technology, appealing to high-end buyers looking for the best in automotive elegance. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-c31858)** - Average price: $65,944.00 - Good/great deal percentage: 30.9% - User rating: 4.8 / 5 - Total listings: 1,084 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-c24430)** - Average price: $25,868.00 - Good/great deal percentage: 30.2% - User rating: 4.88 / 5 - Total listings: 971 - **[2014 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2014-Mercedes-Benz-S-Class-c24217)** - Average price: $21,915.00 - Good/great deal percentage: 30.4% - User rating: 4.89 / 5 - Total listings: 792 This analysis is based on CarGurus' proprietary market data from March 23, 2026, CarGurus experts' opinions, and generative AI.