Used 2021 Mercedes-Benz E-Class for Sale nearFresno, CA
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 44,589
- Stock #:
- 5278P
- VIN:
- W1KZF8DB9MA928251


Sponsored by Modesto Toyota
2021 Mercedes-Benz E-Class
E 350 RWD
44,589 mi
$29,550
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Neva Gray/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,470
- Stock #:
- T3914A
- VIN:
- W1KZF8DB7NB032767

Sponsored Listing
2022 Mercedes-Benz E-Class
E 350 RWD
25,470 mi
$34,165
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 58,539
- Stock #:
- 16561
- VIN:
- W1KZF8DB0LA764290

Sponsored Listing
2020 Mercedes-Benz E-Class
E 350 Sedan RWD
58,539 mi
$21,919
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 53,676
- Stock #:
- 70195114
- VIN:
- W1KZF8DB9MA938651

2021 Mercedes-Benz E-Class
E 350 RWD
53,676 mi
$29,147
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,283
- Stock #:
- 26181
- VIN:
- W1KZF8DB7LA837350

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
23,283 mi
$28,685
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 72,303
- Stock #:
- MA924987T
- VIN:
- W1KZF8DB5MA924987

2021 Mercedes-Benz E-Class
E 350 RWD
72,303 mi
$25,580
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,487
- Stock #:
- 63015
- VIN:
- W1KZF8DB5MA921166

2021 Mercedes-Benz E-Class
E 350 RWD
46,487 mi
$27,550
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,793
- Stock #:
- 4P2926
- VIN:
- W1KZF8DB4NB097253

2022 Mercedes-Benz E-Class
E 350 RWD
41,793 mi
$31,965
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- No Color
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,691
- Stock #:
- 8131
- VIN:
- W1KZF8DB6MA989623

2021 Mercedes-Benz E-Class
E 350 RWD
26,691 mi
$33,133
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,687
- Stock #:
- 61838
- VIN:
- W1KZF8DB7NB087008

2022 Mercedes-Benz E-Class
E 350 RWD
40,687 mi
$31,550
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 46,794
- Stock #:
- 005616
- VIN:
- W1KZF8DB7MB005616

2021 Mercedes-Benz E-Class
E 350 RWD
46,794 mi
$32,345
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,086
- Stock #:
- 162645
- VIN:
- W1K1J6BB4MF162645

2021 Mercedes-Benz E-Class
AMG E 53 Coupe 4MATIC
46,086 mi
$48,257
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- designo Diamond White Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- No Color
- Transmission:
- 9-Speed Automatic
- Mileage:
- 80,164
- Stock #:
- 8071
- VIN:
- W1KZF8DB5MA874396

2021 Mercedes-Benz E-Class
E 350 RWD
80,164 mi
$26,547
CarGurus Analysis:
2021 Mercedes-Benz E-Class
With 123 currently listed for sale near Fresno, CA and an average price of $30,044.00, 35.8% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars and CarGurus experts gave it an 8.33 / 10.
93.5% of 2021 E-Class models on CarGurus are accident free.
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 28,819
- Stock #:
- C85086A
- VIN:
- W1KZF5KB1MA878091

2021 Mercedes-Benz E-Class
E 450 4MATIC Sedan AWD
28,819 mi
$39,355
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 46,134
- Stock #:
- FNF833869
- VIN:
- W1KZF8DB6LA833869

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
46,134 mi
$26,740
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 69,557
- Stock #:
- 907352
- VIN:
- W1KZF8DB9MA907352

2021 Mercedes-Benz E-Class
E 350 RWD
69,557 mi
$27,257
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 58,539
- Stock #:
- 16561
- VIN:
- W1KZF8DB0LA764290

2020 Mercedes-Benz E-Class
E 350 Sedan RWD
58,539 mi
$21,919
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Graphite Gray
- Combined gas mileage:
- 27 MPG
- Fuel type:
- Gasoline
- Interior color:
- Neva Gray/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,470
- Stock #:
- T3914A
- VIN:
- W1KZF8DB7NB032767

2022 Mercedes-Benz E-Class
E 350 RWD
25,470 mi
$34,165
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Black
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 44,589
- Stock #:
- 5278P
- VIN:
- W1KZF8DB9MA928251

2021 Mercedes-Benz E-Class
E 350 RWD
44,589 mi
$29,550
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Convertible
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,389
- Stock #:
- 4P2857
- VIN:
- W1K1K6BB9NF180234

2022 Mercedes-Benz E-Class
AMG E 53 Cabriolet 4MATIC
44,389 mi
$50,465
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Mystic Blue Metallic
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Cashmere Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,356
- Stock #:
- MA964703X
- VIN:
- W1KZF8DB0MA964703

2021 Mercedes-Benz E-Class
E 350 RWD
36,356 mi
$31,980
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 255 hp 2L I4
- Exterior color:
- Polar White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,588
- Stock #:
- 65504
- VIN:
- W1KZF8DB5MA913472

2021 Mercedes-Benz E-Class
E 350 RWD
31,588 mi
$34,311
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- E-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 28,819
- Stock #:
- C85086A
- VIN:
- W1KZF5KB1MA878091

Sponsored Listing
2021 Mercedes-Benz E-Class
E 450 4MATIC Sedan AWD
28,819 mi
$39,355
CarGurus Analysis: 2021 Mercedes-Benz E-Class
overall

Summary
With 123 currently listed for sale near Fresno, CA and an average price of $30,044.00, 35.8% of 2021 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz E-Class 4.7 / 5 stars and CarGurus experts gave it an 8.33 / 10.
93.5% of 2021 E-Class models on CarGurus are accident free.
Why it stands out
The 2021 Mercedes-Benz E-Class stands out as a midsize luxury car that aims to be many things at once. It is described as the company’s most practical and versatile car, and it offers four body styles, four engines, and dozens of color schemes. That breadth gives buyers a wide range of personalities to choose from, whether they want something fast, efficient, quiet, or more richly appointed. For shoppers who want a Mercedes-Benz that can cover a lot of ground without giving up refinement, that flexibility is a major part of its appeal.
For 2021, the E-Class receives a mid-cycle update for the infotainment system, engines, and exterior styling. The test car mentioned is the AMG E53, which features a mild-hybrid inline-six powertrain. The model’s strengths also include a great ride quality and impressive technology, which help reinforce its luxury-car mission. At the same time, advanced safety features are not standard, so buyers may need to look carefully at equipment levels if those systems matter to them.
Other model years to consider
- Average price: $34,495.00
- Good/great deal percentage: 40.2%
- User rating: 5 / 5
- Total listings: 127
- Average price: $28,600.00
- Good/great deal percentage: 29.6%
- User rating: 5 / 5
- Total listings: 142
- Average price: $28,240.00
- Good/great deal percentage: 28.2%
- User rating: 4.76 / 5
- Total listings: 170
This analysis is based on CarGurus' proprietary market data from August 25, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
4.7 Overall rating
Filter by rating
ayekun j
Reviewed a 2021 Mercedes-Benz E 350 4MATIC on Mar 2, 2026
Johnson Ayekun, Best car money can buy,the E350 is in a class of excellent beautiful inside and out side,slik design, elegance meet with performance
Heather S
Reviewed a 2021 Mercedes-Benz E-Class on Jan 9, 2026
I love all the features, still learning a lot about them. I would seriously suggest reading the owners manual or watching some how to videos.
Elvis K. N
Reviewed a 2021 Mercedes-Benz E-Class on Jan 29, 2023
Very nice car but does not have active lane keeping assist.
Elvis E
Reviewed a 2021 Mercedes-Benz E 350 RWD on Apr 30, 2023
Best Car Ever! Great gas mileage. No problems so far at all! This is my 2nd Mercedes E-Class and I have no regrets buying it. Has great power. Can go really fast in seconds. If you like sporty exterior and luxury interior then this Mercedes Benz E350 2021 is the car for you!
2021 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 Coupe RWD | $64,950 |
| E 450 Cabriolet RWD | $71,950 |
| E 450 4MATIC Coupe AWD | $67,450 |
| AMG 53 E Sedan 4MATIC | $73,900 |
| AMG E 63 S Sedan 4MATIC | $107,500 |
| E 450 4MATIC Sedan AWD | $62,000 |
| E 350 4MATIC | $56,750 |
| E 350 RWD | $54,250 |
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
2021 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz E-Class prices has changed over time.
See more price trends2021 Mercedes-Benz E-Class Pricing Analysis: Fresno, CA Market Report
Pricing by Nearby Locations
Market Area: Fresno, CA
Key Insights
- Highest Prices in Santa Cruz: The market in Santa Cruz, CA commands the highest average price at $38,848, likely due to its affluent demographic and demand for luxury vehicles.
- Lowest Prices in Merced: Conversely, Merced, CA offers the lowest average price at $27,480, indicating a more price-sensitive market with potentially higher inventory turnover.
- Price Variation with Inventory: Cities like Visalia (127 listings) and Stockton (119 listings) show average prices around $30K–$32K, suggesting that higher inventory levels may stabilize pricing in these areas.
City-Level Pricing
| City | Total Listings | Avg Price |
|---|---|---|
| Santa Cruz, CA | 109 | $38,848 |
| Stockton, CA | 119 | $32,182 |
| Modesto, CA | 113 | $29,232 |
| Visalia, CA | 127 | $30,035 |
| San Jose, CA | 119 | $30,777 |
| Merced, CA | 114 | $27,480 |
Pricing by Trim Packages
Key Insights
- RWD Trims Lead Inventory: The E 350 RWD trim is the most common with 78 listings, indicating strong demand for rear-wheel drive options in this market.
- AWD Trims Offer Premium Features: The E 350 4MATIC trim, with 50 listings, provides all-wheel drive and a higher MSRP, appealing to buyers seeking enhanced performance and safety.
- Luxury Premium for AMG Trims: The AMG E 63 S Sedan 4MATIC is priced at $107,500 MSRP, reflecting the significant markup associated with high-performance luxury vehicles.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| E 350 RWD | 78 | $54,250 | RWD | 2.0L 255 hp I4 |
| E 350 4MATIC | 50 | $56,750 | AWD | 2.0L 255 hp I4 |
| E 450 4MATIC Sedan AWD | 14 | $62,000 | AWD | 3.0L 362 hp I6 |
| AMG E 63 S Sedan 4MATIC | 15 | $107,500 | AWD | 4.0L 603 hp V8 |
| E 450 Cabriolet RWD | 12 | $71,950 | RWD | 3.0L 362 hp I6 |
| E 450 Coupe RWD | 15 | $64,950 | RWD | 3.0L 362 hp I6 |
| E 450 4MATIC Coupe AWD | 12 | $67,450 | AWD | 3.0L 362 hp I6 |
| E 450 4MATIC Cabriolet AWD | 7 | $74,450 | AWD | 3.0L 362 hp I6 |
Pricing Analysis by Model Year
Key Insights
- Significant Premium for New Models: The 2026 model is priced at $89,957, which is approximately 40.5% above its MSRP, indicating strong demand for the latest model.
- Steep Depreciation for Older Models: The 2016 model shows a drastic drop to $10,839, reflecting a depreciation of -79.5% from its original MSRP, highlighting the rapid value loss typical of luxury vehicles.
- Best Value in Recent Models: The 2022 model is priced at $34,080, which is -38.5% below its original MSRP, making it a compelling option for buyers looking for a balance of luxury and value.
Model Year Pricing
| Model Year | Original MSRP | Avg Price | Price vs MSRP |
|---|---|---|---|
| 2026 Mercedes-Benz E-Class | $63,900 | $89,957 | +40.5% |
| 2022 Mercedes-Benz E-Class | $54,950 | $34,080 | -38.5% |
| 2020 Mercedes-Benz E-Class | $54,050 | $28,600 | -47.1% |
| 2019 Mercedes-Benz E-Class | $53,500 | $25,995 | -51.4% |
| 2018 Mercedes-Benz E-Class | $52,950 | $28,240 | -46.5% |
| 2017 Mercedes-Benz E-Class | $52,150 | $21,870 | -58.1% |
| 2016 Mercedes-Benz E-Class | $52,650 | $10,839 | -79.5% |
| 2015 Mercedes-Benz E-Class | $51,800 | $14,470 | -72.0% |
These recommendations are based on CarGurus' proprietary market data from August 27, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
How much does the 2021 Mercedes-Benz E-Class cost?
| Metric | Value |
|---|---|
| Current Average Price | $37,902 |
| Year-Round Low | $37,960.19 |
| Year-Round High | $42,509.49 |
| Average Price a Year Ago | $40,885 |
| Change vs. Last Year | −7.30% |
Prices have softened 7.30% compared to this time last year, making it a favorable time to shop this model year.
There are 841 listings available, which gives you a meaningful amount of inventory to compare.
If you find a listing below $37,960.19, that's toward the low end of the year-round range and worth acting on quickly.
Is the 2021 Mercedes-Benz E-Class a good car?
Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.
Owners consistently praise its blend of luxury, performance, and beautiful design, along with the comfortable interior and advanced features. The E-Class also stands out for its powerful engine choices and broad appeal across body styles and personalities. On the downside, some owners feel it is overpriced, and some note the absence of certain features they expected in a luxury car.
That mix fits the E-Class’s role as a versatile midsize luxury car that can be fast, efficient, quiet, or richly appointed depending on how you spec it. The market also looks healthy, with 32.6% of listings marked as good or great deals.
Is the 2021 Mercedes-Benz E-Class reliable?
Owners rate it 4.7/5, a strong signal of long-term satisfaction.
Owner feedback points to a car that feels dependable, with praise centered on its luxury, comfort, and overall satisfaction over time. The powertrains are described as quiet and excellent choices for a car this size, and the model’s refined driving character supports the sense that it is built for long-term use.
Mercedes also emphasizes the 48-volt system’s ability to support frequent engine shutoffs and restarts, which is part of the car’s efficiency-minded design. For used buyers, the main long-term ownership risk is that this is a complex luxury car, so condition and maintenance history matter a lot.
What should I look for when buying a used 2021 Mercedes-Benz E-Class?
Accident-free inventory is solid at 76.2% — always verify the vehicle history report.
You should still check the history report carefully, because a clean listing percentage does not replace a proper records review. Prioritize a pre-purchase inspection that focuses on electronics, suspension behavior, and any signs of uneven wear. Since this is a luxury model with a lot of equipment, condition and maintenance history matter more than mileage alone.
Key things to evaluate:
- Trim level: The cabin is richly appointed even in base form, but the more upscale versions add richer materials, more elaborate stitching, and features like illuminated and motorized tweeters on the front doors.
- Powertrain: The lineup includes multiple engines, from a 2.0-liter turbo four-cylinder to electrified inline-six powertrains, plus the AMG E53’s 429 hp setup and the E63 S’s 603 hp V8.
- Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, while all other driver-assist features are optional.
- Infotainment: The car uses MBUX with two 12-inch screens, touch and swipe controls, natural voice processing, and online search; Apple CarPlay and Android Auto are not wireless, and OTA updates are not included.
- Fuel efficiency: The E450 4Matic sedan returns 26 mpg combined, the E350 4Matic sedan returns 25 mpg combined, the AMG E53 sedan returns 25 mpg combined, and the E63 sedan returns 18 mpg combined.
Which 2021 Mercedes-Benz E-Class trim should I buy?
The 2021 Mercedes-Benz E-Class is offered in 4 trim levels: E350, E450, AMG E53, AMG E63 S.
Here's the short version:
- Base trim: The E350 gives you the core E-Class experience, but advanced safety features are not standard, so you may need to shop carefully for the equipment you want.
- Sweet-spot trim: The E450 is the best balance for many buyers because it adds the electrified inline-six powertrain and keeps the E-Class’s quiet, refined character.
- Premium/top trim: The AMG E53 is the most compelling upscale pick if you want stronger performance, rear-biased AWD, and the variable-rate air suspension without going all the way to the extreme AMG model.
- Off-road trim: Not applicable here.
Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard, but other driver-assist features remain optional.
Is now a good time to buy a used 2021 Mercedes-Benz E-Class?
This is a moderate, selective buyer’s market, so you have room to compare listings carefully.
- Deal availability: 32.6% of listings are priced as good or great deals.
- Inventory: There are 841 listings available.
- Price trend: Prices have softened 7.30% compared with last year.
- Clean inventory: 76.2% of listings are accident-free.
If you find a listing below $37,960.19, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2021 Mercedes-Benz E-Class's resale value?
The current average of $37,902 sits slightly below last year's $40,885.
That price movement suggests the market has already adjusted downward, which can help future resale if you buy at the right number. If you pay close to the current average or better, you may have a better chance of limiting depreciation pressure later. Strong equipment, clean history, and desirable trim choices should matter more when it comes time to sell.
Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.
Is the 2021 Mercedes-Benz E-Class safe?
The 2021 E-Class sedan and wagon earned a five-star overall rating from NHTSA, with five-star ratings in frontal, side, and rollover tests, though the driver's side received a four-star frontal crash rating.
It earns a 10/10 safety score from our experts.
The standard safety suite includes forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring. Other driver-assistance features are optional, so you should check the exact equipment on any used example. The 2020 E-Class sedan was rated a Top Safety Pick+ by IIHS, but the 2021 text does not repeat that result for this model year.
Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?
If you're weighing the 2021 against nearby model years, here's how to think about it:
Choose the 2021 if:
- 32.6% of listings are priced as good or great deals.
- Accident-free inventory is solid at 76.2% — always verify the vehicle history report.
- Price trend: Prices have softened 7.30% compared with last year.
- Owners rate it 4.7/5 — a strong satisfaction signal.
- It brings a mid-cycle update for the infotainment system, engines, and exterior styling.
Consider the 2020 if:
- At $30,657, the 2020 costs less than the current year's $37,902 average.
- It offers a stylish design and impressive technology.
Consider the 2022 if:
- At $40,138, the 2022 costs more than the current year's $37,902 average.
- It keeps the refreshed formula and adds more standard convenience equipment.
The bottom line: If you want the best mix of updated tech, strong owner satisfaction, and a softer used-market price, the 2021 is the smart default. If your priority is spending less, the 2020 is the value play; if you want a slightly newer example and do not mind paying more, the 2022 is the cleaner follow-on choice.
These recommendations are based on CarGurus' proprietary market data from August 21, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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