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Used 2021 Lexus RX for Sale near Knoxville, TN

129 results
Knoxville, TN
2021 Lexus RX 350L Luxury AWD Mercedes Benz of Knoxville

2021 Lexus RX

350L Luxury AWD

29,039 miles

$45,871

Good Deal
Knoxville, TN
12 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
29,039
Stock number:
TT067A
VIN:
JTJJZKFA0M2028605

Sponsored

2020 Lexus RX 350 FWD

2020 Lexus RX

350 FWD

88,987 miles

$29,302

Fair Deal
Knoxville, TN
12 mi away
Year:
2020
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Atomic Silver
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
88,987
Stock number:
P12646
VIN:
2T2HZMAA4LC162694

Sponsored

2022 Lexus RX 350 F Sport Handling AWD

2022 Lexus RX

350 F Sport Handling AWD

33,774 miles

$40,800

Great Deal
Hazard, KY
97 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Circuit Red
Transmission:
8-Speed Automatic
Mileage:
33,774
Stock number:
1007P
VIN:
2T2YZMDA5NC338408

Sponsored

2022 Lexus RX 350 FWD

2022 Lexus RX

350 FWD

10,027 miles

$44,797

Good Deal
Store transfer to Knoxville, TN
773 mi away • Price includes $799 shipping Price includes $799 shipping
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Red
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Brown
Transmission:
Automatic
Mileage:
10,027
Stock number:
28326088
VIN:
2T2HZMAA3NC250719

2021 Lexus RX 350 AWD

2021 Lexus RX

350 AWD

50,871 miles

$36,347

Great Deal
Store transfer to Knoxville, TN
377 mi away • Price includes $349 shipping Price includes $349 shipping
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
Automatic
Mileage:
50,871
Stock number:
28156245
VIN:
2T2HZMDA4MC261660

Preparing for a close up...

Photos coming soon

2020 Lexus RX

350 F Sport AWD

86,038 miles

$30,995

Great Deal
Knoxville, TN
3 mi away
Year:
2020
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
White
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
Automatic
Mileage:
86,038
Stock number:
LC227260
VIN:
2T2SZMDAXLC227260

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350 AWD

102,075 miles

$28,937

Fair Deal
Arden, NC
84 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Eminent White Pearl
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
102,075
Stock number:
T60833
VIN:
2T2HZMDA4MC260833

Preparing for a close up...

Photos coming soon

2020 Lexus RX

350 FWD

88,987 miles

$29,302

Fair Deal
Knoxville, TN
12 mi away
Year:
2020
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Atomic Silver
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
88,987
Stock number:
P12646
VIN:
2T2HZMAA4LC162694

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350L Luxury AWD

29,039 miles

$45,871

Good Deal
Knoxville, TN
12 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
29,039
Stock number:
TT067A
VIN:
JTJJZKFA0M2028605

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 F Sport Handling AWD

33,774 miles

$40,800

Great Deal
Hazard, KY
97 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Circuit Red
Transmission:
8-Speed Automatic
Mileage:
33,774
Stock number:
1007P
VIN:
2T2YZMDA5NC338408

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 FWD

40,774 miles

$36,989

Great Deal
Kingsport, TN
88 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
White (Parchment)
Transmission:
8-Speed Automatic
Mileage:
40,774
Stock number:
ZNZ259749
VIN:
2T2HZMAA2NC259749

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 FWD

38,704 miles

$38,332

Great Deal
Johnson City, TN
90 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
38,704
Stock number:
ANC249587
VIN:
2T2AZMAA5NC249587

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350L AWD

45,807 miles

$39,898

Good Deal
Johnson City, TN
91 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Matador Red Mica
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
45,807
Stock number:
AN2041083
VIN:
JTJHZKFA6N2041083

Sponsored

  1. Home
  2. / Used Cars
  3. / Lexus RX
  4. / 2021
  5. / Tennessee
  6. / Knoxville
Overview
Reviews
FAQs

CarGurus Analysis: 2021 Lexus RX

Picture of 2021 Lexus RX

Summary

  • With 1,829 currently listed for sale on CarGurus and an average price of $35,773.40, 32.3% of 2021 Lexus RXs for sale on CarGurus are rated as good or great deals.
  • Favorably reviewed: Owners rated the 2021 Lexus RX 4.7 / 5 stars and CarGurus experts gave it an 7.8 / 10.
  • 79% of 2021 RX models on CarGurus are accident free.
  • The 2021 Lexus RX combined luxurious comfort with reliability, featuring upgraded safety technology and a smooth ride, although it had some limitations in performance and technology usability.

Why it stands out

The 2021 Lexus RX distinguished itself as a luxury SUV that emphasized comfort and reliability, making it an appealing choice for buyers seeking both style and practicality. It featured an excellent ride quality and offered great value for money, ensuring a pleasant driving experience. Additionally, the introduction of new standard safety systems enhanced its appeal by prioritizing passenger protection.

Other model years to consider

  • 2020 Lexus RX: This year offers $33,379.27 average price, 33% good/great deals, 4.8/5 user rating, 8.2/10 expert rating, 1,269 listings.
  • 2023 Lexus RX: This year offers $47,405.06 average price, 37% good/great deals, 4.6/5 user rating, 7.2/10 expert rating, 3,056 listings.
  • 2022 Lexus RX: This year offers $40,414.56 average price, 36% good/great deals, 4.6/5 user rating, 7.3/10 expert rating, 2,526 listings.

This analysis is based on CarGurus' proprietary market data from December 16, 2025, CarGurus experts' opinions, and generative AI.

4.8 Overall rating

(26 reviews)
Archie C
5.0
Reviewed a 2021 Lexus RX on Oct 13, 2024

Very reliable stylish looking drives well. Good suspension. Fun to drive

Dan F
5.0
Reviewed a 2021 Lexus RX on Mar 26, 2024

Condition of the vehicle was 10/10. Interior was detailed extremely well. Mechanically it all checked out as well. Only issue was since it is a Canadian vehicle the digital climate controls appear to be stuck in Celsius. Could be a troubleshoot to resolve it but other than that perfect vehicle.

Haidar A
5.0
Reviewed a 2021 Lexus 350L AWD on Apr 25, 2024

The car is perfect if only the brakes were as responsive of a German car.

Ann W
5.0
Reviewed a 2021 Lexus RX on Feb 22, 2023

This car is beautiful and drives so smooth.

Anonymous
5.0
Reviewed a 2021 Lexus RX on Nov 04, 2023

Perfect for me and my family (except for the Parchment interior that my kids will probably ruin) but I love it!so I will do everything to keep it clean.. this car is superior family luxury! Have kid? Needs spacious trunk and seating but doesnt want it looking huge and bulky outside? Needs reliability? Need quality? Need LUXURY? look no further the RX 350 IS THE CAR FOR YOU!

2021 Lexus RX FAQs

How much does the 2021 Lexus RX cost in Knoxville, TN?

The average 2021 Lexus RX costs about $35,552.90. The average price has decreased by -4.1% since last year. The 130 for sale near Knoxville, TN on CarGurus, range from $24,666 to $48,674 in price.

Is the 2021 Lexus RX a good car?

CarGurus experts gave the 2021 Lexus RX an overall rating of 7.8/10 and 2021 Lexus RX owners have rated the vehicle a 4.7/5 stars on average. If a vehicle has both strong expert and owner reviews, you can feel confident in its quality. If either expert reviews, owner reviews, or both are spotty, you might want to do some research to figure out where the car falls short.

How many 2021 Lexus RX vehicles in Knoxville, TN have no reported accidents or damage?

114 out of 130 for sale near Knoxville, TN have no reported accidents or damage.

Is the 2021 Lexus RX safe?

CarGurus experts gave the 2021 Lexus RX a safety rating of 8/10.

What is the fuel economy of the 2021 Lexus RX?

Depending on the engine and options, the 2021 Lexus RX gets between 21 and 23 MPG (or EV battery range).

What fuel types are available?

Gasoline engines are available.

  • 2024 Lexus RX in Knoxville TN

  • 2023 Lexus RX

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  • Lexus RX 350 FWD

  • Lexus RX 350 AWD

  • Lexus RX 350 F Sport AWD in Knoxville TN

  • Lexus RX 350 F Sport Handling AWD

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