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Used 2022 Lexus RX for Sale near Knoxville, TN

161 results
Knoxville, TN
2022 Lexus RX 350 AWD AutoNation Honda West Knoxville

2022 Lexus RX

350 AWD

51,860 miles

$39,678

Fair Deal
Knoxville, TN
12 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Atomic Silver
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
Automatic
Mileage:
51,860
Stock number:
NC364159
VIN:
2T2HZMDA8NC364159

Sponsored

2023 Lexus RX 350 Premium FWD

2023 Lexus RX

350 Premium FWD

49,580 miles

$43,734

Fair Deal
Knoxville, TN
12 mi away
Year:
2023
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
275 hp 2.4L I4
Exterior color:
Nebula Gray Pearl
Combined gas mileage:
25 MPG
Fuel type:
Gasoline
Interior color:
Black W/Black Open Pore
Transmission:
8-Speed Automatic
Mileage:
49,580
Stock number:
2930A
VIN:
2T2BAMBA8PC003288

Sponsored

2022 Lexus RX 350 FWD

2022 Lexus RX

350 FWD

38,704 miles

$38,332

Great Deal
Johnson City, TN
90 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
38,704
Stock number:
ANC249587
VIN:
2T2AZMAA5NC249587

Sponsored

2022 Lexus RX 350 FWD

2022 Lexus RX

350 FWD

10,027 miles

$44,797

Good Deal
Store transfer to Knoxville, TN
773 mi away • Price includes $799 shipping Price includes $799 shipping
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Red
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Brown
Transmission:
Automatic
Mileage:
10,027
Stock number:
28326088
VIN:
2T2HZMAA3NC250719

2021 Lexus RX 350 AWD

2021 Lexus RX

350 AWD

50,871 miles

$36,347

Great Deal
Store transfer to Knoxville, TN
377 mi away • Price includes $349 shipping Price includes $349 shipping
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
Automatic
Mileage:
50,871
Stock number:
28156245
VIN:
2T2HZMDA4MC261660

Preparing for a close up...

Photos coming soon

2023 Lexus RX

350 Premium FWD

24,501 miles

$47,595

Fair Deal
Alcoa, TN
10 mi away
Year:
2023
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
275 hp 2.4L I4
Exterior color:
Iridium
Combined gas mileage:
25 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
24,501
Stock number:
P9088
VIN:
JTJCHMAA1P2003585

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350 AWD

102,075 miles

$28,937

Fair Deal
Arden, NC
84 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Eminent White Pearl
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
102,075
Stock number:
T60833
VIN:
2T2HZMDA4MC260833

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350L Luxury AWD

29,039 miles

$45,871

Good Deal
Knoxville, TN
12 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
29,039
Stock number:
TT067A
VIN:
JTJJZKFA0M2028605

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 FWD

52,479 miles

$36,997

Great Deal
Store transfer to Knoxville, TN
1,945 mi away • Price includes $1,999 shipping Price includes $1,999 shipping
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic Overdrive
Mileage:
52,479
Stock number:
28142708
VIN:
2T2AZMAA5NC233566

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 F Sport Handling AWD

33,774 miles

$40,800

Great Deal
Hazard, KY
97 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Circuit Red
Transmission:
8-Speed Automatic
Mileage:
33,774
Stock number:
1007P
VIN:
2T2YZMDA5NC338408

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 FWD

40,774 miles

$36,989

Great Deal
Kingsport, TN
88 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
White (Parchment)
Transmission:
8-Speed Automatic
Mileage:
40,774
Stock number:
ZNZ259749
VIN:
2T2HZMAA2NC259749

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 FWD

38,704 miles

$38,332

Great Deal
Johnson City, TN
90 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
38,704
Stock number:
ANC249587
VIN:
2T2AZMAA5NC249587

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350L Luxury AWD

29,039 miles

$45,871

Good Deal
Knoxville, TN
12 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
8-Speed Automatic
Mileage:
29,039
Stock number:
TT067A
VIN:
JTJJZKFA0M2028605

Sponsored

  1. Home
  2. / Used Cars
  3. / Lexus RX
  4. / 2022
  5. / Tennessee
  6. / Knoxville
Overview
Reviews
FAQs

CarGurus Analysis: 2022 Lexus RX

Picture of 2022 Lexus RX

Summary

  • With 2,526 currently listed for sale on CarGurus and an average price of $40,414.60, 35.6% of 2022 Lexus RXs for sale on CarGurus are rated as good or great deals.
  • Favorably reviewed: Owners rated the 2022 Lexus RX 4.6 / 5 stars and CarGurus experts gave it an 7.3 / 10.
  • 84.2% of 2022 RX models on CarGurus are accident free.
  • The 2022 Lexus RX combined a smooth ride quality with standard advanced safety features, solidifying its status as the brand's best-selling model despite its aging design.

Why it stands out

The 2022 Lexus RX stood out for its exceptional ride quality, ensuring a comfortable driving experience that many owners appreciated. It also included standard advanced safety features, reflecting Lexus's commitment to driver and passenger safety. Despite its dated design and some ergonomic considerations, the RX maintained strong sales figures, showcasing its enduring appeal in the luxury SUV market.

Other model years to consider

  • 2020 Lexus RX: This year offers $33,379.27 average price, 33% good/great deals, 4.8/5 user rating, 8.2/10 expert rating, 1,269 listings.
  • 2021 Lexus RX: This year offers $35,773.39 average price, 32% good/great deals, 4.7/5 user rating, 7.8/10 expert rating, 1,829 listings.
  • 2023 Lexus RX: This year offers $47,405.06 average price, 37% good/great deals, 4.6/5 user rating, 7.2/10 expert rating, 3,056 listings.

This analysis is based on CarGurus' proprietary market data from December 16, 2025, CarGurus experts' opinions, and generative AI.

4.6 Overall rating

(24 reviews)
Anonymous
5.0
Reviewed a 2022 Lexus RX on Feb 19, 2024

I just recently purchased a 2022 Lexus RX 350L(2 days actually). Still learning all the many features. Smooth, quiet ride. Great power response. Coming from a 2020 Mercedes GLE 350 I was a bit skeptical if It would measure up. It really does!!

Uday T
4.0
Reviewed a 2022 Lexus RX on Jun 06, 2023

Great car, drives smooth. Lacks pick up power for a V6

Anonymous
5.0
Reviewed a 2022 Lexus 350 AWD on Jun 06, 2023

No unneeded frills but lots of quality of life items. Love the backup camera and surround view, easily the best one out of all the cars we test drove (GMC, Buick, Ford, Nissan). Suspension is solid, corners well, and plenty of power.

Anonymous
4.0
Reviewed a 2022 Lexus 350 FWD on Feb 08, 2023

Car is wonderful except for the gas mileage. Pretty, nice size, comfortable, good safety features.

Anonymous
5.0
Reviewed a 2022 Lexus 350 FWD on Oct 03, 2022

An excellent car which is loaded with features and fun to drive. It is smooth and has a very quiet cabin. Also very luxurious materials in the cabin and fine leather seats,

2022 Lexus RX FAQs

How much does the 2022 Lexus RX cost in Knoxville, TN?

The average 2022 Lexus RX costs about $39,838.91. The average price has decreased by -4.9% since last year. The 161 for sale near Knoxville, TN on CarGurus, range from $26,674 to $53,556 in price.

Is the 2022 Lexus RX a good car?

CarGurus experts gave the 2022 Lexus RX an overall rating of 7.3/10 and 2022 Lexus RX owners have rated the vehicle a 4.6/5 stars on average. If a vehicle has both strong expert and owner reviews, you can feel confident in its quality. If either expert reviews, owner reviews, or both are spotty, you might want to do some research to figure out where the car falls short.

How many 2022 Lexus RX vehicles in Knoxville, TN have no reported accidents or damage?

161 out of 161 for sale near Knoxville, TN have no reported accidents or damage.

Is the 2022 Lexus RX safe?

CarGurus experts gave the 2022 Lexus RX a safety rating of 8/10.

What is the fuel economy of the 2022 Lexus RX?

Depending on the engine and options, the 2022 Lexus RX gets between 21 and 25 MPG (or EV battery range).

What fuel types are available?

Gasoline engines are available.

  • 2025 Lexus RX in Knoxville TN

  • 2024 Lexus RX in Knoxville TN

  • 2023 Lexus RX

  • 2021 Lexus RX in Knoxville TN

  • 2020 Lexus RX

  • 2019 Lexus RX

  • Lexus RX 350 FWD

  • Lexus RX 350 AWD

  • Lexus RX 350 F Sport AWD in Knoxville TN

  • Lexus RX 350 F Sport Handling AWD

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  • Lexus RX in Knoxville TN

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