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Used 2022 Lexus RX for Sale near Knoxville, TN

191 results
Knoxville, TN
2022 Lexus RX 350L AWD CDJR of Elizabethton

2022 Lexus RX

350L AWD

18,127 miles

$45,987

Fair Deal
Elizabethton, TN
96 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
290 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
21 MPG
Fuel type:
Gasoline
Interior color:
Glazed Caramel
Transmission:
8-Speed Automatic
Mileage:
18,127
Stock number:
W164257A
VIN:
JTJHZKFA0N2042603

Sponsored

2023 Lexus RX 350 Premium AWD

2023 Lexus RX

350 Premium AWD

7,046 miles

$49,900

Fair Deal
Lenoir City, TN
22 mi away
Year:
2023
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
275 hp 2.4L I4
Exterior color:
Black (Caviar)
Combined gas mileage:
24 MPG
Fuel type:
Gasoline
Interior color:
Birch
Transmission:
Automatic
Mileage:
7,046
Stock number:
FT25581A
VIN:
2T2BAMCA4PC020314

Sponsored

2021 Lexus RX 350 F Sport Handling AWD

2021 Lexus RX

350 F Sport Handling AWD

80,736 miles

$36,855

Fair Deal
Knoxville, TN
12 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black (Obsidian)
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
80,736
Stock number:
2917A
VIN:
2T2YZMDA6MC266679

Sponsored

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350 FWD

119,751 miles

$24,999

Good Deal
Corbin, KY
70 mi away
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Brown
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Transmission:
8-Speed Automatic
Mileage:
119,751
Stock number:
MC212392
VIN:
2T2HZMAA7MC212392

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 AWD

41,525 miles

$41,721

Fair Deal
Knoxville, TN
12 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Nightfall Mica
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Glazed Caramel
Transmission:
8-Speed Automatic
Mileage:
41,525
Stock number:
2757A
VIN:
2T2HZMDA0NC319619

Preparing for a close up...

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2022 Lexus RX

350 F Sport Handling AWD

58,922 miles

$39,977

Good Deal
Oak Ridge, TN
20 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Transmission:
Automatic
Mileage:
58,922
Stock number:
Z3099B
VIN:
2T2YZMDA4NC341171

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2022 Lexus RX

350 FWD

40,774 miles

$32,998

Great Deal
Cleveland, TN
80 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
White (Parchment)
Transmission:
8-Speed Automatic
Mileage:
40,774
Stock number:
ANC259749
VIN:
2T2HZMAA2NC259749

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Photos coming soon

2022 Lexus RX

350 FWD

55,652 miles

$39,306

Fair Deal
Knoxville, TN
11 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Black (Caviar)
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Black
Transmission:
8-Speed Automatic
Mileage:
55,652
Stock number:
A17168AHC
VIN:
2T2JZMAA7NC228711

Preparing for a close up...

Photos coming soon

2021 Lexus RX

350 FWD

69,114 miles

$31,997

Great Deal
Store transfer to Knoxville, TN
1,945 mi away • Price includes $1,999 shipping Price includes $1,999 shipping
Year:
2021
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Blue
Combined gas mileage:
23 MPG
Fuel type:
Gasoline
Interior color:
Gray
Transmission:
Automatic
Mileage:
69,114
Stock number:
27676202
VIN:
2T2AZMAA4MC200508

Preparing for a close up...

Photos coming soon

2023 Lexus RX

350 Premium FWD

41,121 miles

$42,998

Great Deal
Store transfer to Knoxville, TN
141 mi away • Price includes $0 shipping Price includes $0 shipping
Year:
2023
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
Front-Wheel Drive
Engine:
275 hp 2.4L I4
Exterior color:
Silver
Combined gas mileage:
25 MPG
Fuel type:
Gasoline
Interior color:
Gray
Transmission:
Automatic
Mileage:
41,121
Stock number:
28103403
VIN:
JTJCHMAA3P2000381

Preparing for a close up...

Photos coming soon

2022 Lexus RX

350 F Sport Handling AWD

33,774 miles

$41,800

Good Deal
Hazard, KY
97 mi away
Year:
2022
Make:
Lexus
Model:
RX
Body type:
SUV / Crossover
Doors:
4 doors
Drivetrain:
All-Wheel Drive
Engine:
295 hp 3.5L V6
Exterior color:
Gray
Combined gas mileage:
22 MPG
Fuel type:
Gasoline
Interior color:
Circuit Red
Transmission:
8-Speed Automatic
Mileage:
33,774
Stock number:
1007P
VIN:
2T2YZMDA5NC338408

Sponsored

  1. Home
  2. / Used Cars
  3. / Lexus RX
  4. / 2022
  5. / Tennessee
  6. / Knoxville
Overview
Reviews
FAQs

CarGurus Analysis: 2022 Lexus RX

Picture of 2022 Lexus RX

Summary

  • With 2,583 currently listed for sale on CarGurus and an average price of $40,523.30, 35.5% of 2022 Lexus RXs for sale on CarGurus are rated as good or great deals.
  • Favorably reviewed: Owners rated the 2022 Lexus RX 4.6 / 5 stars and CarGurus experts gave it an 7.3 / 10.
  • 84.6% of 2022 RX models on CarGurus are accident free.
  • The 2022 Lexus RX maintained its status as the automaker's best-selling model, offering a comfortable ride and standard advanced safety features, though it featured a design that some found polarizing.

Why it stands out

The 2022 Lexus RX distinguished itself with its exceptional ride quality, providing a smooth and comfortable driving experience that appealed to many consumers. It also prioritized safety by incorporating standard advanced safety features, enhancing peace of mind for drivers and passengers alike. Despite being a carryover model, the RX maintained its position as Lexus’s best-selling vehicle, demonstrating its continued popularity in a competitive market.

Other model years to consider

  • 2021 Lexus RX: This year offers $35,808.26 average price, 33% good/great deals, 4.7/5 user rating, 7.8/10 expert rating, 1,840 listings.
  • 2020 Lexus RX: This year offers $33,383.04 average price, 32% good/great deals, 4.8/5 user rating, 8.2/10 expert rating, 1,248 listings.
  • 2023 Lexus RX: This year offers $47,685.72 average price, 36% good/great deals, 4.6/5 user rating, 7.2/10 expert rating, 3,126 listings.

This analysis is based on CarGurus' proprietary market data from December 3, 2025, CarGurus experts' opinions, and generative AI.

4.6 Overall rating

(24 reviews)
Anonymous
5.0
Reviewed a 2022 Lexus RX on Feb 19, 2024

I just recently purchased a 2022 Lexus RX 350L(2 days actually). Still learning all the many features. Smooth, quiet ride. Great power response. Coming from a 2020 Mercedes GLE 350 I was a bit skeptical if It would measure up. It really does!!

Uday T
4.0
Reviewed a 2022 Lexus RX on Jun 06, 2023

Great car, drives smooth. Lacks pick up power for a V6

Anonymous
5.0
Reviewed a 2022 Lexus 350 AWD on Jun 06, 2023

No unneeded frills but lots of quality of life items. Love the backup camera and surround view, easily the best one out of all the cars we test drove (GMC, Buick, Ford, Nissan). Suspension is solid, corners well, and plenty of power.

Anonymous
4.0
Reviewed a 2022 Lexus 350 FWD on Feb 08, 2023

Car is wonderful except for the gas mileage. Pretty, nice size, comfortable, good safety features.

Anonymous
5.0
Reviewed a 2022 Lexus 350 FWD on Oct 03, 2022

An excellent car which is loaded with features and fun to drive. It is smooth and has a very quiet cabin. Also very luxurious materials in the cabin and fine leather seats,

2022 Lexus RX FAQs

How much does the 2022 Lexus RX cost in Knoxville, TN?

The average 2022 Lexus RX costs about $40,552.30. The average price has decreased by -4.5% since last year. The 176 for sale near Knoxville, TN on CarGurus, range from $26,635 to $56,500 in price.

Is the 2022 Lexus RX a good car?

CarGurus experts gave the 2022 Lexus RX an overall rating of 7.3/10 and 2022 Lexus RX owners have rated the vehicle a 4.6/5 stars on average. If a vehicle has both strong expert and owner reviews, you can feel confident in its quality. If either expert reviews, owner reviews, or both are spotty, you might want to do some research to figure out where the car falls short.

How many 2022 Lexus RX vehicles in Knoxville, TN have no reported accidents or damage?

176 out of 176 for sale near Knoxville, TN have no reported accidents or damage.

Is the 2022 Lexus RX safe?

CarGurus experts gave the 2022 Lexus RX a safety rating of 8/10.

What is the fuel economy of the 2022 Lexus RX?

Depending on the engine and options, the 2022 Lexus RX gets between 21 and 25 MPG (or MPGe).

What fuel types are available?

Gasoline engines are available.

  • 2025 Lexus RX in Knoxville TN

  • 2024 Lexus RX in Knoxville TN

  • 2023 Lexus RX

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