Used 2022 Lexus RX for Sale nearKnoxville, TN
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 28,082
- Stock #:
- Z0249
- VIN:
- 2T2BAMCA5PC035761


Sponsored by Mercedes Benz of Knoxville
2023 Lexus RX
350 Premium AWD
28,082 mi
$48,482
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 59,064
- Stock #:
- 3095A
- VIN:
- JTJHZKEA9N2028524

Sponsored Listing
2022 Lexus RX
350L FWD
59,064 mi
$40,682
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 93,454
- Stock #:
- IP2445
- VIN:
- 2T2HZMAA4MC190965

Sponsored Listing
2021 Lexus RX
350 FWD
93,454 mi
$33,128
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Green
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 73,819
- Stock #:
- 70130956
- VIN:
- 2T2HZMAA2NC224807

2022 Lexus RX
350 FWD
73,819 mi
$36,797
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 30,122
- Stock #:
- EPC032332
- VIN:
- 2T2BAMCA0PC032332

2023 Lexus RX
350 Premium AWD
30,122 mi
$43,997
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (TAN)
- Transmission:
- Automatic
- Mileage:
- 55,580
- Stock #:
- 29078668
- VIN:
- 2T2HZMDAXMC264918

2021 Lexus RX
350 AWD
55,580 mi
$39,147
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 52,296
- Stock #:
- KFA61612A
- VIN:
- 2T2BAMBA7PC009020

2023 Lexus RX
350 FWD
52,296 mi
$39,060
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Nightfall Mica
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Palomino
- Transmission:
- 8-Speed Automatic
- Mileage:
- 33,329
- Stock #:
- P4559
- VIN:
- 2T2BAMBAXPC015264

2023 Lexus RX
350 Premium FWD
33,329 mi
$43,498
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Graphite)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 43,169
- Stock #:
- PC016430
- VIN:
- 2T2BAMCA8PC016430

2023 Lexus RX
350 F Sport Handling AWD
43,169 mi
$46,374
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch w/Matte Walnut Trim
- Transmission:
- Automatic
- Mileage:
- 54,790
- Stock #:
- B26263A
- VIN:
- 2T2HZMAA8MC210764

2021 Lexus RX
350 FWD
54,790 mi
$36,146
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Palomino
- Transmission:
- 8-Speed Automatic
- Mileage:
- 40,315
- Stock #:
- PC015337
- VIN:
- 2T2BAMCA2PC015337

2023 Lexus RX
350 Premium AWD
40,315 mi
$44,074
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 80,588
- Stock #:
- C4637
- VIN:
- JTJHZKEA8M2020266

2021 Lexus RX
350L FWD
80,588 mi
$33,399
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 63,183
- Stock #:
- C4635
- VIN:
- 2T2SZMAA5MC195131

2021 Lexus RX
350 F Sport FWD
63,183 mi
$36,549
CarGurus Analysis:
2022 Lexus RX
With 2,148 currently listed for sale and an average price of $39,155, 36.0% of 2022 Lexus RXs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus RX 4.77 / 5 stars and CarGurus experts gave it a 7.33 / 10.
82.5% of 2022 RX models on CarGurus are accident free.
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 93,454
- Stock #:
- IP2445
- VIN:
- 2T2HZMAA4MC190965

2021 Lexus RX
350 FWD
93,454 mi
$33,128
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 51,185
- Stock #:
- MC192501A
- VIN:
- 2T2HZMAA5MC192501

2021 Lexus RX
350 FWD
51,185 mi
$35,326
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- White Pearl
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Peppercorn
- Transmission:
- 8-Speed Automatic
- Mileage:
- 55,716
- Stock #:
- D5369P
- VIN:
- 2T2BAMBA1PC011250

-$1,689
2023 Lexus RX
350 Luxury FWD
55,716 mi
$47,243
$45,554
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 62,299
- Stock #:
- 70023773
- VIN:
- 2T2HZMAA9MC182330

-$1,000
2021 Lexus RX
350 FWD
62,299 mi
$36,397
$35,397
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 22,977
- Stock #:
- A18966A
- VIN:
- 2T2BAMCA4PC014108

2023 Lexus RX
350 Luxury AWD
22,977 mi
$52,498
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 59,064
- Stock #:
- 3095A
- VIN:
- JTJHZKEA9N2028524

2022 Lexus RX
350L FWD
59,064 mi
$40,682
- Year:
- 2023
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 275 hp 2.4L I4
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 29,467
- Stock #:
- PC022220
- VIN:
- 2T2BAMCA5PC022220

2023 Lexus RX
350 Premium AWD
29,467 mi
$44,436
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 92,571
- Stock #:
- 052771
- VIN:
- JTJHZMDA9M2052771

2021 Lexus RX
350 AWD
92,571 mi
$31,399
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 65,335
- Stock #:
- 66683
- VIN:
- 2T2HZMAA1MC189658

2021 Lexus RX
350 FWD
65,335 mi
$33,518
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 77,827
- Stock #:
- C4570
- VIN:
- 2T2HZMAA3NC254950

Sponsored Listing
2022 Lexus RX
350 FWD
77,827 mi
$35,699
CarGurus Analysis: 2022 Lexus RX
overall
Summary
With 2,148 currently listed for sale and an average price of $39,155, 36.0% of 2022 Lexus RXs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus RX 4.77 / 5 stars and CarGurus experts gave it a 7.33 / 10.
82.5% of 2022 RX models on CarGurus are accident free.
Why it stands out
The 2022 Lexus RX stands out as a luxury SUV that leans more toward comfort and refinement than outright performance. It remains appealing because of its attractive design, luxury amenities, driving comfort, and tried-and-true reliability, while also being the automaker’s best-selling model. For 2022, it is a carryover with minimal changes, including new colors and a standalone fog lamps option.
Its strongest qualities are the ones buyers are most likely to notice every day: great ride quality and standard advanced safety features. Owners also describe it as comfortable, loaded with features, and smooth-riding, with a luxury feel that makes it pleasant to drive. The main drawbacks are that its design can be polarizing and its ergonomics are not especially strong, and some owners also felt it lacked pickup power and were concerned about gas mileage.
Other model years to consider
- Average price: $45,927
- Good/great deal percentage: 36.7%
- User rating: 5 / 5
- Total listings: 2,937
- Average price: $33,192
- Good/great deal percentage: 37.4%
- User rating: 4.88 / 5
- Total listings: 1,349
- Average price: $49,435
- Good/great deal percentage: 37.1%
- User rating: 5 / 5
- Total listings: 2,909
This analysis is based on CarGurus' proprietary market data from September 21, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
4.8 Overall rating
Filter by rating
Marc G
Reviewed a 2022 Lexus RX on Dec 29, 2025
Good and reliable vehicle. Luxury is the cornerstone of this SUV.
Larry M
Reviewed a 2022 Lexus RX on Jul 24, 2026
I currently own a Lexus RX350. It’s been a reliable vehicle with a great quiet ride. I am looking at a newer RX350 at the current time
Terry C
Reviewed a 2022 Lexus RX on Apr 12, 2025
Non turbo Toyota reliability and smoothness and composure of a S class.
Uday T
Reviewed a 2022 Lexus RX on Jun 6, 2023
Great car, drives smooth. Lacks pick up power for a V6
2022 Lexus RX Trims
| Trim type | MSRP |
|---|---|
| 350 F Sport Handling FWD | $51,800 |
| 350L Luxury FWD | $54,750 |
| 350 F Sport AWD | $50,800 |
| 350L FWD | $48,750 |
| 350L AWD | $50,150 |
| 350 F Sport Handling AWD | $53,200 |
| 350 AWD | $47,320 |
| 350 FWD | $45,920 |
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
2022 Lexus RX Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Lexus RX prices has changed over time.
See more price trends2022 Lexus RX Pricing Analysis: Knoxville, TN Market Report
Pricing by Nearby Locations
Market Area: Knoxville, TN
Key Insights
- Consistent Pricing Across Cities: Cities like Morristown, TN ($37,656), Greeneville, TN ($37,656), and Johnson City, TN ($37,656) show identical average prices, indicating a stable market with similar demand and supply dynamics.
- Slightly Higher Prices in Chattanooga: Chattanooga, TN ($38,092) is the highest priced city in the area, which may reflect a stronger demand or lower inventory compared to other nearby locations.
- Inventory Levels are Comparable: The total listings across these cities range from 170 to 196, suggesting a balanced inventory that supports stable pricing.
City-Level Pricing
| City | Total Listings | Avg Price |
|---|---|---|
| Morristown, TN | 185 | $37,656 |
| Greeneville, TN | 190 | $37,656 |
| Johnson City, TN | 196 | $37,656 |
| Chattanooga, TN | 171 | $38,092 |
| Dalton, GA | 170 | $38,092 |
| Greenville, SC | 181 | $40,280 |
Pricing by Trim Packages
Key Insights
- FWD Trims Lead Inventory: The 350 FWD trim is the most common with 222 listings, indicating strong demand for front-wheel drive options.
- AWD Trims Offer Premium Features: The 350 AWD trim, with 146 listings, provides a balance of features and performance, appealing to buyers in regions with variable weather.
- Price Variability Among Trims: The 350 F Sport Handling AWD trim, priced at $53,200 MSRP, represents the highest price point, reflecting its premium features and performance enhancements.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| 350 FWD | 222 | $45,920 | FWD | 3.5L 295 hp V6 |
| 350 AWD | 146 | $47,320 | AWD | 3.5L 295 hp V6 |
| 350 F Sport AWD | 60 | $50,800 | AWD | 3.5L 295 hp V6 |
| 350 F Sport Handling AWD | 44 | $53,200 | AWD | 3.5L 295 hp V6 |
| 350L AWD | 19 | $50,150 | AWD | 3.5L 290 hp V6 |
| 350L FWD | 27 | $48,750 | FWD | 3.5L 290 hp V6 |
| 350 F Sport FWD | 12 | $49,400 | FWD | 3.5L 295 hp V6 |
Pricing Analysis by Model Year
Key Insights
- Newer Models Command Premium Prices: The 2025 Lexus RX is priced at $57,809, reflecting a 17.9% increase over its original MSRP, indicating strong demand for the latest model.
- Significant Depreciation for Older Models: The 2015 Lexus RX shows the steepest depreciation at -68.4%, suggesting that older models may offer better value for budget-conscious buyers.
- Best Value in Recent Models: The 2021 Lexus RX is priced at $27,988, representing a -38.5% depreciation, making it an attractive option for buyers seeking a balance of price and modern features.
Model Year Pricing
| Model Year | Original MSRP | Avg Price | Price vs MSRP |
|---|---|---|---|
| 2025 Lexus RX | $48,975 | $57,809 | +17.9% |
| 2024 Lexus RX | $48,600 | $54,339 | +11.8% |
| 2023 Lexus RX | $47,800 | $50,650 | +5.8% |
| 2021 Lexus RX | $45,220 | $27,988 | -38.5% |
| 2020 Lexus RX | $44,150 | $33,730 | -23.6% |
| 2019 Lexus RX | $43,820 | $28,854 | -34.0% |
| 2018 Lexus RX | $43,470 | $25,769 | -40.6% |
| 2017 Lexus RX | $43,220 | $22,923 | -47.1% |
| 2016 Lexus RX | $41,900 | $22,631 | -46.0% |
| 2015 Lexus RX | $40,970 | $12,900 | -68.4% |
| 2014 Lexus RX | $39,760 | $16,984 | -57.3% |
These recommendations are based on CarGurus' proprietary market data from September 23, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
How much does the 2022 Lexus RX cost?
| Metric | Value |
|---|---|
| Current Average Price | $39,160 |
| Year-Round Low | $39,160 |
| Year-Round High | $41,001 |
| Average Price a Year Ago | $41,001 |
| Change vs. Last Year | −4.49% |
Prices have softened 4.49% compared to this time last year, making it a favorable time to shop this model year.
There are 2,145 listings available, which gives you a solid pool of inventory to compare.
Is the 2022 Lexus RX a good car?
Yes — the 2022 Lexus RX earns a 4.77/5 user rating and a 7.33/10 expert rating. The model scores 8/10 across Cost effectiveness and Safety.
Owners consistently praise its comfortable cabin, smooth ride, and luxury feel, and they also call out its loaded feature set and advanced tech. The RX is framed as a strong fit if you want a relaxed, upscale driving experience rather than a sporty one.
The main trade-offs are its lack of pickup power and its polarizing design, and the ergonomics are not especially strong. In market terms, 36.7% of listings are priced as good or great deals, so you still have room to shop selectively.
Is the 2022 Lexus RX reliable?
Owners rate it 4.77/5, a strong signal of long-term satisfaction.
The owner feedback points to a vehicle that feels comfortable, dependable, and trouble-free over time, with a reputation for long-term confidence. The expert assessment also reinforces that theme by describing Lexus’ tradition of reliability as part of the RX’s appeal.
The RX’s comfort-focused setup and established mechanical formula should help reduce ownership surprises, though used buyers should still pay close attention to maintenance records and overall condition.
What should I look for when buying a used 2022 Lexus RX?
Accident-free inventory is solid at 82.4% — always verify the vehicle history report.
You should still run a history report on any RX you’re considering, even if the listing looks clean at first glance. Prioritize a pre-purchase inspection that checks the suspension, brakes, electronics, and interior wear, since comfort and tech are central to this model’s appeal. Focus on condition details that affect daily livability, including seat wear, infotainment operation, and evidence of uneven maintenance.
Key things to evaluate:
- Trim level: The gas model is offered in base 350, F Sport, and L trim levels. The base and L trims emphasize comfort and luxury appeal, while the F Sport adds a more athletic look with 20-inch wheels, black-housing mirrors, dark window trim, F Sport badging, and a unique front fascia. The base and L trims use 18-inch wheels, so you’ll want to check whether the equipment gap matters to you before paying more for the sportier appearance.
- Powertrain: The RX 350 uses a 3.5-liter V6 with 295 horsepower and 267 pound-feet of torque, paired with an eight-speed automatic. Front-wheel drive is standard, with all-wheel drive available. If you want more efficiency, the hybrid RX 450h adds two electric motors and returns stronger fuel economy, but that is a separate model.
- Safety package: Lexus Safety System 2.0+ is standard, and it includes adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Blind-spot monitoring, rear cross-traffic alert, a head-up display, and Lexus Enform Safety Connect are also standard. The IIHS top-tier “plus” designation depends on optional triple-beam LED headlights.
- Infotainment: Standard infotainment uses an 8-inch touchscreen, with a 12.3-inch screen available. The system includes Android Auto and Apple CarPlay integration, wireless charging, Amazon Alexa compatibility, a WiFi hotspot, navigation with cloud-based updates, and premium audio options. The touchpad interface is a usability weak point, so test it yourself before you buy.
- Fuel efficiency: The RX 350 is rated at 20 mpg city, 27 mpg highway, and 23 combined, while AWD or the three-row L model lowers those figures by 1 mpg. The least efficient gas version is the 350L AWD at 18 mpg city, 25 mpg highway, and 23 combined.
Which 2022 Lexus RX trim should I buy?
The 2022 Lexus RX is offered in 3 trim levels: base 350, F Sport, and L.
Here's the short version:
- base 350: This is the trim to start with if you want the RX’s core strengths without paying for extra styling or seating changes. It gives you the standard luxury feel, the standard safety suite, and the most straightforward path into the model.
- F Sport: Choose this if you want the most aggressive appearance and a more athletic setup. It adds 20-inch wheels, unique exterior treatment, and performance-oriented hardware, but the content also makes clear that the RX still leans more toward comfort than true sportiness.
- L: Pick this if you want the three-row, 7-passenger layout. It’s the right choice when passenger flexibility matters more than the sportier look of the F Sport.
The safety package is standard across the lineup, but the IIHS top-tier result depends on the optional triple-beam LED headlights.
Is now a good time to buy a used 2022 Lexus RX?
This is a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile listings.
- Deal availability: 36.7% of listings are priced as good or great deals.
- Inventory: There are 2,145 listings available.
- Price trend: Prices have softened 4.49% compared with last year.
- Clean inventory: 82.4% of listings are accident-free.
If you find a listing below $39,160, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2022 Lexus RX's resale value?
The current average of $39,160 sits slightly below last year's $41,001.
That softer pricing can help you as a buyer now, but it also suggests future sellers may need to stay realistic on asking price. If the market continues to favor shoppers, resale values may remain under pressure unless a vehicle is especially clean, well-equipped, and well maintained.
Vehicles with strong owner satisfaction ratings, like this model year's 4.77/5, tend to retain buyer demand, which supports resale value over time.
Is the 2022 Lexus RX safe?
The 2022 Lexus RX earns a Top Safety Pick rating from the Insurance Institute for Highway Safety, but only with the optional triple-beam LED headlights. It also earns four-star ratings overall from NHTSA, with five-star ratings in side crash tests and four-star ratings in frontal crash and rollover resistance.
It earns an 8/10 safety score from our experts.
Lexus Safety System 2.0+ is standard, and it brings adaptive cruise control with stop-and-go, lane-departure warning with steering assist, road-sign recognition, lane-keeping assist, lane-tracing assist, pre-collision braking with cyclist and pedestrian detection, and intelligent high beams. Blind-spot monitoring, rear cross-traffic alert, a head-up display, and Lexus Enform Safety Connect are also standard.
The main caveat is that the RX misses the IIHS top-tier “plus” designation unless you get the optional triple-beam LED headlights. That means you should pay close attention to headlight equipment when comparing used listings.
Should I buy a 2022 Lexus RX or consider a different year?
If you're weighing the 2022 against nearby model years, here's how to think about it:
Choose the 2022 if:
- 36.7% of listings are priced as good or great deals.
- Accident-free inventory is solid at 82.4% — always verify the vehicle history report.
- Price trend: Prices have softened 4.49% compared with last year.
- Owners rate it 4.77/5 — a strong satisfaction signal.
- It’s a carryover year with minimal changes, including new colors and a standalone fog lamps option.
Consider the 2021 if:
- At $35,429, the 2021 costs less than the current year's $39,160 average.
- It keeps the familiar comfort-and-reliability formula with a few tech upgrades.
Consider the 2023 if:
- At $45,904, the 2023 costs more than the current year's $39,160 average.
- It brings a redesigned, more modern package with stronger technology and a fresh feel.
The bottom line: If you want the best balance of price, inventory, and proven satisfaction, the 2022 is the sensible default. If you’re especially price-sensitive, the 2021 is the value play; if you want a newer redesign and can spend more, the 2023 is the upgrade path.
These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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