The 2000 Grand Cherokee was available in two trim levels, Laredo and Limited. Two engines were available, a six-cylinder and an eight-cylinder, and vehicles were equipped with two-wheel or four-wheel drive.

After a complete redesign in 1999, the 2000 Grand Cherokee received only minor appearance and equipment changes. The 4.7-liter PowerTech V8 was now available in two-wheel-drive versions and with the Selec-Trac transfer case in four-wheel-drive versions. New softer leather seat material was available and two new exterior colors were offered.

The Cherokee was the first unibody sport-utility vehicle, as distinct from the traditional body-on-frame approach. The advantages are much higher rigidity and much lower weight, which contribute to the Cherokee's good handling.

Although the basic Cherokee was available with rear-drive only, it wouldn't really be a Jeep without four-wheel drive. There are two levels of 4WD available for the Cherokee, part-time Command-Trac and full-time Selec-Trac.

Drivers report the 2000 Jeep Grand Cherokee is safe, comfortable, and reliable. They also say it gets low gas mileage and "things break."