2021 Mercedes-Benz S-Class vs 2021 Acura TLX
Overview | |
MSRP$37,500 | MSRP$109,800 |
Listings329 | Listings196 |
Ratings & Reviews | |
User Reviews | User Reviews |
Expert reviews7.3 out of 10 | Expert reviews7.5 out of 10 |
Pros
Cons
| Pros
Cons
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2021 Acura TLX Reviews SummaryAcura, the premium brand in the Honda portfolio, has released the second-generation of its midsize sport sedan, the TLX. Now on its own new platform, no longer shared with the Honda Accord, TLX arrives with a new exterior, interior, and powertrain choices. Positioned above the compact ILX in the Acura lineup, the new TLX strives to make its mark for 2021. | |
2021 Mercedes-Benz S-Class Reviews SummaryThe S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. | |
Popular Features & Specs | |
Engine2.0L 272 hp I4 | Engine3.0L 429 hp I6 |
Drive TrainFWD | Drive TrainAWD |
Seating Capacity5 | Seating Capacity5 |
Horsepower272 hp @ 6500 rpm | Horsepower429 hp @ 6100 rpm |
MPG City22 | MPG City20 |
MPG Highway31 | MPG Highway29 |
Engine | |
Engine Name2.0L 272 hp I4 | Engine Name3.0L 429 hp I6 |
Torque280 lb-ft @ 1600 rpm | Torque384 lb-ft @ 1800 rpm |
Horsepower272 hp @ 6500 rpm | Horsepower429 hp @ 6100 rpm |
DrivetrainFWD | DrivetrainAWD |
Fuel Economy | |
MPG City22 | MPG City20 |
MPG Highway31 | MPG Highway29 |
Interior | |
Leather Seats | Leather SeatsOptional |
Seating Capacity5 | Seating Capacity5 |
Key Features | |
Navigation System | Navigation SystemOptional |
Sunroof/MoonroofStandard | Sunroof/MoonroofOptional |
Safety | |
Front Crash Overall5 | Front Crash Overall |
Side Crash Overall5 | Side Crash Overall |
Dimensions & Capacity | |
Cargo Space13.5 cu ft | Cargo Space12.9 cu ft |
Curb Weight3709 lbs | Curb Weight4740 lbs |
Height56.4 in | Height59.2 in |
Length194.6 in | Length208.2 in |
Width75.2 in | Width83.0 in |
Wheelbase113.0 in | Wheelbase126.6 in |
Maximum Payload838 lbs | Maximum Payload |
Number of doors4 | Number of doors4 |
Overview | ||
MSRP | $37,500 | $109,800 |
Listings | ||
Ratings & Reviews | ||
User reviews | ||
Expert reviews | 7.3 out of 10Read full review | 7.5 out of 10Read full review |
Pros & cons | Pros
Cons
| Pros
Cons
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Summary | Acura, the premium brand in the Honda portfolio, has released the second-generation of its midsize sport sedan, the TLX. Now on its own new platform, no longer shared with the Honda Accord, TLX arrives with a new exterior, interior, and powertrain choices. Positioned above the compact ILX in the Acura lineup, the new TLX strives to make its mark for 2021. | The S-Class not only sits at the top of the Mercedes hierarchy in price and prestige, but it has also long served as a technological showcase. In the press release for the redesigned 2021 S-Class, Mercedes repeatedly noted the innovations—from anti-lock brakes to airbags—that were introduced on the big sedan and eventually trickled down to mainstream vehicles. With the previous generation dating back to the 2014 model year (with a significant update for 2018), the Mercedes-Benz S-Class was in need of an update to maintain that status, and to keep pace with other full-size luxury sedans like the Audi A8, BMW 7 Series, and Lexus LS. To do that, the new S-Class gets a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork, among other features. The 2021 S-Class launches in two configurations, both with 4Matic all-wheel drive (AWD) and EQ Boost mild-hybrid systems. The S500 4Matic has a six-cylinder engine, while the S580 4Matic has a V8. We spent a few days with the Mercedes-Benz S580 for this review. A Mercedes-Maybach S680 4Matic version will follow in the first half of 2022, and you can expect a new AMG performance version sometime in the future as well. |
Video | ||
Popular Features & Specs | ||
Engine | 2.0L 272 hp I4 | 3.0L 429 hp I6 |
Drive Train | FWD | AWD |
Seating Capacity | 5 | 5 |
Horsepower | 272 hp @ 6500 rpm | 429 hp @ 6100 rpm |
MPG City | 22 | 20 |
MPG Highway | 31 | 29 |
Engine | ||
Engine Name | 2.0L 272 hp I4 | 3.0L 429 hp I6 |
Torque | 280 lb-ft @ 1600 rpm | 384 lb-ft @ 1800 rpm |
Horsepower | 272 hp @ 6500 rpm | 429 hp @ 6100 rpm |
Drivetrain | FWD | AWD |
Fuel Economy | ||
MPG City | 22 | 20 |
MPG Highway | 31 | 29 |
Interior | ||
Leather Seats | Optional | |
Seating Capacity | 5 | 5 |
Key Features | ||
Navigation System | Optional | |
Sunroof/Moonroof | Standard | Optional |
Safety | ||
Front Crash Overall | 5 | |
Side Crash Overall | 5 | |
Dimensions & Capacity | ||
Cargo Space | 13.5 cu ft | 12.9 cu ft |
Curb Weight | 3709 lbs | 4740 lbs |
Height | 56.4 in | 59.2 in |
Length | 194.6 in | 208.2 in |
Width | 75.2 in | 83.0 in |
Wheelbase | 113.0 in | 126.6 in |
Maximum Payload | 838 lbs | |
Number of doors | 4 | 4 |
The 2021 Acura TLX was a striking, sporty sedan that stood out in a crowded class. Its assertive stance was highlighted by a steeply raked windshield, a fastback-style roofline, and an integrated tail spoiler. The front featured a bold grille pattern radiating from the central Acura logo, flanked by horizontal "jewel eye" LED headlights. Twin trapezoidal tailpipes added to its sporty appeal. Inside, the TLX boasted a "sport sedan cockpit" with authentic materials like metal, leather, and wood, creating a high-quality feel. The 10.2-inch infotainment screen was strategically placed, enhancing the car's modern and cohesive interior design.
In contrast, the 2021 Mercedes-Benz S-Class maintained a classic exterior design, subtly refined for improved aerodynamics with a drag coefficient of 0.22. The S-Class was larger than its predecessor, with a longer wheelbase and increased dimensions, giving it a commanding presence. The interior was centered around a prominent infotainment touchscreen and digital instrument cluster, with a minimalist design approach. Ambient lighting with 250 LED elements and a choice of 64 colors added a luxurious touch. High-quality materials like Nappa leather and open-pore wood trim were standard, although the piano-black trim was prone to smudging.
















The 2021 Acura TLX was equipped with a new turbocharged 2.0-liter inline four-cylinder engine, delivering 272 horsepower and 280 pound-feet of torque. It featured a 10-speed automatic transmission with drive-by-wire and shift-by-wire systems. Front-wheel drive was standard, with Acura's Super-Handling All-Wheel Drive (SH-AWD) available. The TLX offered an engaging driving experience with its Integrated Dynamics System, allowing drivers to choose between Comfort, Normal, Sport, and Individual modes. The car's adaptive dampers and increased torsional stiffness contributed to its nimble handling and balanced weight distribution.
The 2021 Mercedes-Benz S-Class offered two engine options: the S500 4Matic with a 3.0-liter turbocharged inline-six producing 429 horsepower and 384 pound-feet of torque, and the S580 4Matic with a 4.0-liter twin-turbo V8 generating 496 horsepower and 516 pound-feet of torque. Both models featured a nine-speed automatic transmission and EQ Boost, a mild-hybrid system providing additional electric assist. The S-Class boasted impressive acceleration, with 0-60 mph times of 4.8 seconds for the S500 and 4.4 seconds for the S580. Standard air suspension and rear-wheel steering enhanced ride comfort and maneuverability.
The 2021 Acura TLX's shift-by-wire transmission allowed for a reimagined center console design, featuring a control panel inspired by the NSX. The interior offered comfortable sport bucket seats with 12-way power adjustability and available Milano leather. The rear seat accommodated two adults comfortably, with a 60/40 split-folding design for trunk access. The TLX provided 13.5 cubic feet of cargo space, with a wide trunk opening for easy loading.
The 2021 Mercedes-Benz S-Class offered increased front and rear headroom, as well as more rear legroom compared to its predecessor. The interior featured power-adjustable front seats with 19 motors, heating, ventilation, and massage functions. The center console included a large storage bin and wireless phone charger. Rear-seat passengers enjoyed a spacious console with cupholders and climate controls. The optional Executive Line package added power-adjustable rear seats and four-zone climate control, enhancing rear-seat comfort.
The 2021 Acura TLX was packed with technology, including drive-by-wire, shift-by-wire, and SH-AWD systems. The 10-speed automatic transmission featured Grade Logic Control, Shift Hold Control, and Cornering G Shift Control for optimized performance. The TLX offered ambient interior lighting and the ELS Studio 3D 17-speaker premium audio system for an immersive audio experience. The infotainment system included navigation, Bluetooth, Apple CarPlay, and Android Auto, with a head-up display available in the Advance Package.
The 2021 Mercedes-Benz S-Class featured a 12.3-inch digital instrument cluster and a 12.8-inch OLED central touchscreen with wireless Apple CarPlay and Android Auto. The updated MBUX infotainment system offered increased computing power and a more touchscreen-reliant interface. The S-Class included an augmented-reality head-up display and a 30-speaker Burmester audio system. The car allowed for personal profiles with biometric access and rear-seat occupants could send navigation directions to the front screen.
The 2021 Acura TLX came standard with the AcuraWatch suite of driver-assistance technologies, including adaptive cruise control, blind-spot monitoring, and lane-keeping assist. Additional safety features included a pedestrian injury mitigation design, ACE body structure, and a full complement of airbags. The TLX also offered rear cross-traffic alert, parking sensors, and a surround-view camera system. While not yet tested by IIHS or NHTSA, Acura aimed for top safety ratings.
The 2021 Mercedes-Benz S-Class included a rear-passenger airbag and a comprehensive suite of driver-assist features, such as adaptive cruise control, automated lane centering, and automatic emergency braking. The S-Class also featured traffic-sign recognition, lane-keep assist, and a 360-degree camera system. Mercedes claimed improvements in these systems, with adaptive cruise control and lane-centering performing smoothly and effectively.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Acura TLX is 7.3 out of 10, while the 2021 Mercedes-Benz S-Class scores 7.5 out of 10. Based on these ratings, the 2021 Mercedes-Benz S-Class is the recommended choice for those seeking a higher-rated luxury sedan with advanced features and superior comfort.
Choose the 2021 Mercedes-Benz S-Class if:
- You desire a luxurious and spacious interior with advanced comfort features.
- You appreciate cutting-edge infotainment technology and driver-assist systems.
- You want a powerful engine with impressive acceleration and ride comfort.
Choose the 2021 Acura TLX if:
- You prioritize a sporty driving experience with customizable drive modes.
- You value advanced performance technology and a premium audio system.
- You seek a stylish sedan with a well-designed interior and ample cargo space.
CarGurus highlights

According to CarGurus experts, the overall rating for the 2021 Acura TLX is 7.3 out of 10, while the 2021 Mercedes-Benz S-Class scores 7.5 out of 10. Based on these ratings, the 2021 Mercedes-Benz S-Class is the recommended choice for those seeking a higher-rated luxury sedan with advanced features and superior comfort.
Choose the 2021 Mercedes-Benz S-Class if:
Shop Now- You desire a luxurious and spacious interior with advanced comfort features.
- You appreciate cutting-edge infotainment technology and driver-assist systems.
- You want a powerful engine with impressive acceleration and ride comfort.
Choose the 2021 Acura TLX if:
Shop Now- You prioritize a sporty driving experience with customizable drive modes.
- You value advanced performance technology and a premium audio system.
- You seek a stylish sedan with a well-designed interior and ample cargo space.

By: CarGurus + AI
At CarGurus, our team of experienced automotive writers remain at the heart of our content operation, conducting hands-on car tests and writing insightful guides that are backed by years of industry experience. To complement this, we are harnessing AI to make our content offering more diverse and more helpful to shoppers than ever. To achieve this, our AI systems are based exclusively on CarGurus content, ratings and data, so that what we produce is both unique to CarGurus, and uniquely helpful to car shoppers.



































