Used 2025 Mercedes-Benz S-Class for Sale nearPanama City, FL

Compare 2025 Mercedes-Benz S-Class Trims

The S-Class lineup offers a range of luxury options, from the budget-friendly S 500 4MATIC to the high-performance AMG S 63 E Performance 4MATIC.

• Starting at $86,406
• Best MPG/MPGe: 59 city / 70 hwy
• Most Popular: S 580 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

S 500 4MATIC — "Who It's For"

The S 500 4MATIC is the pick for shoppers who want luxury features without stepping up to higher price points. It offers a solid balance of performance and comfort.

• Avg. market price: $86,406 (updated weekly)
• MPG/MPGe: 21 city / 31 hwy
• Inventory: 41 listings — lower availability; may limit negotiating room
• View S 500 4MATIC listings

S 580e 4MATIC — "Who It's For"

The S 580e 4MATIC is the pick for shoppers who want a luxury hybrid experience without sacrificing performance. It's also one of the most fuel-efficient trims.

• Avg. market price: $98,767 (updated weekly)
• MPG/MPGe: 59 city / 70 hwy
• Inventory: 30 listings — lower availability; may limit negotiating room
• View S 580e 4MATIC listings

S 580 4MATIC — "Who It's For"

The S 580 4MATIC is the pick for shoppers who want a blend of luxury and performance without going for the highest price. It's the most popular trim in the lineup.

• Avg. market price: $105,817 (updated weekly)
• MPG/MPGe: 17 city / 25 hwy
• Inventory: 210 listings
• View S 580 4MATIC listings

AMG S 63 E Performance 4MATIC — "Who It's For"

The AMG S 63 E Performance 4MATIC is the pick for shoppers who want top-tier performance and luxury features. It's designed for those who crave speed and style.

• Avg. market price: $157,757 (updated weekly)
• MPG/MPGe: 46 city / 53 hwy
• Inventory: 136 listings — lower availability; may limit negotiating room
• View AMG S 63 E Performance 4MATIC listings

Maybach S 580 4MATIC — "Who It's For"

The Maybach S 580 4MATIC is the pick for shoppers who want the ultimate in luxury without the highest price tag. It offers a lavish experience with advanced features.

• Avg. market price: $177,850 (updated weekly)
• MPG/MPGe: 16 city / 27 hwy
• Inventory: 36 listings — lower availability; may limit negotiating room
• View Maybach S 580 4MATIC listings

Maybach S 680 4MATIC — "Who It's For"

The Maybach S 680 4MATIC is the pick for shoppers who want the pinnacle of luxury and performance. It features a powerful V12 engine and unmatched comfort.

• Avg. market price: $224,899 (updated weekly)
• MPG/MPGe: 12 city / 20 hwy
• Inventory: 39 listings — lower availability; may limit negotiating room
• View Maybach S 680 4MATIC listings

Trim Recommendations

Most Popular — S 580 4MATIC

With 210 active listings, the S 580 4MATIC is the clear volume leader in the lineup.

Browse S 580 4MATIC listings

Best Budget Option — S 500 4MATIC

At $86,406 avg market price — below the lineup median of $131,787 — it's the most accessible entry point.

Browse S 500 4MATIC listings

Best for Fuel Economy — S 580e 4MATIC

The S 580e 4MATIC offers impressive fuel efficiency with 59 city / 70 hwy MPG/MPGe.

Browse S 580e 4MATIC listings

These recommendations are based on CarGurus' proprietary market data from September 2, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2025 Mercedes-Benz S-Class cost?

Prices have softened 10.29% compared to this time last year, making it a favorable time to shop this model year.

There are 496 listings available, which suggests solid inventory for shoppers comparing trims and prices.

If you find a listing below $126,897.24, that's toward the low end of the year-round range and worth acting on quickly.

Is the 2025 Mercedes-Benz S-Class a good car?

Yes — the 2025 Mercedes-Benz S-Class earns a 5/5 user rating and a 7.33/10 expert rating. The standout strength is Performance at 9/10.

The S-Class is built around comfort, performance, technology, and refinement, and it stays true to that mission with premium interior materials and a cabin that aims for top-tier luxury. It also offers multiple powertrain options, so you can tailor the car more closely to how you want to drive.

The trade-offs are straightforward: you give up cargo space, and the capacitive touch controls can be frustrating to use. Even so, if you want a flagship luxury sedan that prioritizes comfort and polish, this model year fits that brief well.

30.4% of listings are priced as good or great deals, which gives you some room to shop selectively.

Is the 2025 Mercedes-Benz S-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The S-Class is presented as a highly refined flagship with premium construction, and the expert evaluation emphasizes that its systems worked flawlessly during testing. Its performance setup is also described as smooth and civilized, which supports the impression of a well-sorted luxury sedan.

The plug-in hybrid and mild-hybrid powertrains add complexity, so a used example is best approached with careful maintenance records and a thorough pre-purchase inspection. For long-term ownership, you want proof that the car has been serviced consistently and that its electronics and charging-related systems are operating as intended.

What should I look for when buying a used 2025 Mercedes-Benz S-Class?

Accident-free inventory is excellent at 95.8% — clean inventory, standard diligence applies.

You should still run a history report and prioritize a pre-purchase inspection, especially on a car with advanced electronics, multiple powertrain choices, and luxury features that can be expensive to sort out later. Focus on overall condition, interior wear, and whether the technology and driver-assistance systems operate cleanly and consistently.

Key things to evaluate:

• Trim level: The cabin emphasizes premium materials, and the car’s mission is to deliver a level of luxury that is difficult to beat, but the base setup does not include every rear-seat amenity. The Pinnacle trim adds rear-seat features such as an infotainment-system tablet, voice controls, a wireless charging pad, and an entertainment system with two 11.6-inch displays.
• Powertrain: You have multiple powertrain choices, including a turbocharged inline-six, a twin-turbo V8, and plug-in hybrid variants. The lineup also includes efficiency-minded mild-hybrid support on some models, plus strong acceleration across the range.
• Safety package: Standard advanced safety features include forward collision warning with automatic emergency braking, adaptive cruise control, blind-spot monitoring with rear cross-traffic alert, lane-keep assist, automated lane-change assist, evasive steering assistance, automatic reverse braking, a semi-automated parking system, and a surround-view camera system. The Pinnacle trim adds rear-seat side and seatbelt airbags.
• Infotainment: All models have a 12.3-inch digital instrument panel, a 12.8-inch infotainment touchscreen, native navigation with augmented reality video overlays, voice recognition, and a Burmester surround-sound system. A digital key feature is also standard, and the Pinnacle trim adds rear-seat tech and charging upgrades.
• Fuel efficiency: The plug-in hybrid is the efficiency leader with 48 miles of electric range and 23 mpg in combined driving once the battery is depleted. The base six-cylinder is rated at 24 mpg combined, while the V8 is rated at 20 mpg.

Which 2025 Mercedes-Benz S-Class trim should I buy?

The 2025 Mercedes-Benz S-Class is offered in 4 trim levels: S 500, S 580, AMG S 63 E Performance, S 580e.

Here's the short version:

• S 500: This is the entry point, and it gives you the core S-Class experience with the turbocharged inline-six, standard all-wheel drive, and the full luxury-sedan mission intact. It makes the most sense if you want the least expensive way into the lineup without giving up the flagship feel.
• S 580: This trim adds the twin-turbo V8 and more power, making it the better choice if you want stronger performance while staying in the traditional luxury-sedan lane. It suits you if you want the best balance of prestige and straight-line punch.
• AMG S 63 E Performance: This is the performance-focused choice, pairing a V8 with an electric motor for the most dramatic output in the lineup. It is the right pick if you want the quickest, most extreme version and are willing to pay for it.
• S 580e: This is the best-value trim if you want strong performance plus plug-in efficiency, with an estimated 48 miles of electric range and smooth, quiet operation. It is the smartest pick if you can charge at home or work and want the most well-rounded mix of power and efficiency.

The Pinnacle trim adds rear-seat amenities and rear-seat side and seatbelt airbags.

Is now a good time to buy a used 2025 Mercedes-Benz S-Class?

This is a moderate market for selective buyers, so you can shop carefully and still find worthwhile opportunities.

• Deal availability: 30.4% of listings are priced as good or great deals.
• Inventory: There are 496 listings available.
• Price trend: Prices have softened 10.29% compared with last year.
• Clean inventory: 95.8% of listings are accident-free.

If you find a listing below $126,897.24, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2025 Mercedes-Benz S-Class's resale value?

The current average of $127,358 sits slightly below last year's $141,971.

That price movement suggests the market has cooled, which can help you buy more selectively now. For a future seller, the softer current pricing means there may be less immediate upside than in a stronger market, but the S-Class still benefits from its flagship status and broad appeal among luxury shoppers.

Because this model year combines strong demand, premium positioning, and a high satisfaction score, it should remain easier to resell than many mainstream luxury sedans. The key for you is to buy well now, since your eventual resale outcome will depend heavily on how much depreciation you absorb at purchase.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2025 Mercedes-Benz S-Class safe?

It earns a 7/10 safety score from our experts.

Standard advanced safety features include forward collision warning with automatic emergency braking, adaptive cruise control, blind-spot monitoring with rear cross-traffic alert, lane-keep assist, automated lane-change assist, evasive steering assistance, automatic reverse braking, a semi-automated parking system, and a surround-view camera system. The Pinnacle trim adds rear-seat side and seatbelt airbags.

The expert evaluation also notes that these systems worked flawlessly during testing, and the adaptive cruise control is especially strong thanks to smooth transitions between acceleration and braking. One important caveat is that neither NHTSA nor IIHS crash test results have been published for this generation, so you are relying on the car’s standard safety equipment and Mercedes-Benz’s broader safety reputation rather than public crash-test scores.

Should I buy a 2025 Mercedes-Benz S-Class or consider a different year?

If you're weighing the 2025 against nearby model years, here's how to think about it:

Choose the 2025 if:

• 30.4% of listings are priced as good or great deals.
• Accident-free inventory is excellent at 95.8% — clean inventory, standard diligence applies.
• Price trend: Prices have softened 10.29% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• Mercedes gave this year newly standard digital key functionality and a center airbag, plus wider availability of the AMG Line trim package.

The bottom line: If you want the freshest version of this generation with the latest standard equipment and a softer market than last year, the 2025 is the one to target. If your priority is stretching your budget, a nearby model year may still make sense, but you should expect to give up some of the 2025 updates and shop more carefully for condition and equipment.

These recommendations are based on CarGurus' proprietary market data from September 4, 2026, CarGurus experts' opinions, and generative AI.