Used 2025 Mercedes-Benz E-Class for Sale nearSpartanburg, SC

Compare 2025 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to high-performance hybrids, catering to various preferences and needs.

• Starting at $49,574
• Best MPG/MPGe: 54 city / 65 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the AWD price premium. It's the most budget-friendly option in the lineup.

• Avg. market price: $49,574 (updated weekly)
• MPG/MPGe: 25 city / 33 hwy
• Inventory: 529 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the pick for shoppers who want all-wheel drive without stepping up to a higher price point. It's also the most popular trim in the lineup.

• Avg. market price: $52,162 (updated weekly)
• MPG/MPGe: 24 city / 33 hwy
• Inventory: 922 listings
• View E 350 4MATIC listings

E 450 4MATIC — "Who It's For"

The E 450 4MATIC is the pick for shoppers who want a sportier driving experience with the benefits of all-wheel drive. It offers more power and luxury features.

• Avg. market price: $65,955 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 166 listings — lower availability; may limit negotiating room
• View E 450 4MATIC listings

AMG E 53 Hybrid 4MATIC+ — "Who It's For"

The AMG E 53 Hybrid 4MATIC+ is the pick for shoppers who want top-tier performance and efficiency in a luxury sedan. It's designed for those who prioritize power and technology.

• Avg. market price: $85,578 (updated weekly)
• MPG/MPGe: 54 city / 65 hwy
• Inventory: 99 listings — lower availability; may limit negotiating room
• View AMG E 53 Hybrid 4MATIC+ listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 922 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $49,574 avg market price — below the lineup median of $59,058 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — AMG E 53 Hybrid 4MATIC+

With an impressive MPG/MPGe of 54 city / 65 hwy, this hybrid offers the best fuel efficiency in the lineup.

Browse AMG E 53 Hybrid 4MATIC+ listings

These recommendations are based on CarGurus' proprietary market data from September 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2025 Mercedes-Benz E-Class cost?

Prices have softened 4.17% compared to this time last year, making it a favorable time to shop this model year.

There are 759 listings available, which gives you a solid amount of inventory to compare.

Is the 2025 Mercedes-Benz E-Class a good car?

The 2025 Mercedes-Benz E-Class stands out because it leans hard into technology without giving up the comfort and space that have long defined the name. It is described as the most technologically advanced version yet, and its cabin strengths include ambient lighting, a large digital display, a 14.4-inch central touchscreen, and strong emphasis on seats, materials, and legroom.

That makes it a strong fit if you want a luxury sedan that prioritizes advanced tech, comfort, and refinement in equal measure. 36.0% of listings are priced as good or great deals, which gives you some room to shop selectively.

Is the 2025 Mercedes-Benz E-Class reliable?

The 2025 Mercedes-Benz E-Class is presented as a comfort-focused luxury sedan with a strong emphasis on technology, refinement, and a well-appointed cabin. It also offers a useful spread of powertrains, from the E350 and E450 models to the high-performance AMG E 53 Hybrid.

For used buyers, the main long-term ownership risk is that a tech-heavy luxury car can be more expensive to keep in top shape as it ages.

What should I look for when buying a used 2025 Mercedes-Benz E-Class?

Accident-free inventory is excellent at 96.8% — clean inventory, standard diligence applies.

You should still run a vehicle history report and confirm the car’s service records before you buy. Prioritize a thorough inspection of the electronics, interior features, and any driver-assistance equipment, since this model leans heavily on technology. You should also pay close attention to overall condition, because luxury-car upkeep matters more when you plan to keep the car for several years.

Is now a good time to buy a used 2025 Mercedes-Benz E-Class?

This looks like a moderate, selective buyer’s market, so you can shop carefully and still find worthwhile options.

• Deal availability: 36.0% of listings are priced as good or great deals.
• Inventory: There are 759 listings available.
• Price trend: Prices have softened 4.17% compared with last year.
• Clean inventory: 96.8% of listings are accident-free.

If you find a listing below $59,977, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2025 Mercedes-Benz E-Class's resale value?

The current average of $59,985 sits slightly below last year's $62,596.

That price movement suggests the market has eased, which can help you buy more confidently today. For a future seller, it also means resale value may depend heavily on condition, mileage, and how well the car’s technology and luxury features hold up over time. If you keep the car clean, well maintained, and properly documented, you give yourself a better chance of protecting value.

Should I buy a 2025 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2025 against nearby model years, here's how to think about it:

Choose the 2025 if:

• 36.0% of listings are priced as good or great deals.
• Accident-free inventory is excellent at 96.8% — clean inventory, standard diligence applies.
• Price trend: Prices have softened 4.17% compared with last year.

Consider the 2024 if:

• At $55,166, the 2024 costs less than the current year's $59,985 average.
• It brings a redesigned cabin with refined ride quality and premium materials.

Consider the 2026 if:

• It adds a standard biometric fingerprint scanner and a wagon option.
• It expands the lineup with an AMG E 53 Hybrid wagon for buyers who want more utility and performance.

The 2025 is the best all-around choice if you want the newest balance of tech, comfort, and performance without stepping into the next model year. If price matters more than having the latest version, the 2024 is the smarter value play. If you want the newest features and a wagon alternative, the 2026 is worth a look.

These recommendations are based on CarGurus' proprietary market data from September 11, 2026, CarGurus experts' opinions, and generative AI.