Used 2022 Mercedes-Benz S-Class for Sale nearSaint Paul, MN

Compare 2022 Mercedes-Benz S-Class Trims in Saint Paul, MN

The S-Class offers a blend of luxury and performance, with options ranging from the value-focused S 500 to the high-end Maybach trims.

• Starting at $55,168
• Best MPG/MPGe: 21 city / 30 hwy
• Most Popular: S 580 4MATIC AWD

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

S 500 4MATIC AWD — "Who It's For"

The S 500 is the pick for shoppers who want luxury features without the higher price of the S 580. It's a great entry point into the S-Class lineup.

• Avg. market price: $55,168 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 51 listings
• View S 500 4MATIC AWD listings

S 580 4MATIC AWD — "Who It's For"

The S 580 is the pick for shoppers who want a powerful engine and advanced features without stepping up to the Maybach. It's the most popular trim in the lineup.

• Avg. market price: $55,168 (updated weekly)
• MPG/MPGe: 16 city / 25 hwy
• Inventory: 90 listings
• View S 580 4MATIC AWD listings

Maybach S 580 4MATIC AWD — "Who It's For"

The Maybach S 580 is the pick for shoppers who want top-tier luxury and performance without going for the highest-priced option.

• Avg. market price: $55,168 (updated weekly)
• MPG/MPGe: 15 city / 24 hwy
• Inventory: 13 listings — lower availability; may limit negotiating room
• View Maybach S 580 4MATIC AWD listings

Maybach S 680 4MATIC AWD — "Who It's For"

The Maybach S 680 is the pick for shoppers who want the ultimate luxury experience with a powerful V12 engine.

• Avg. market price: $55,168 (updated weekly)
• MPG/MPGe: 12 city / 21 hwy
• Inventory: 14 listings — lower availability; may limit negotiating room
• View Maybach S 680 4MATIC AWD listings

Trim Recommendations

Most Popular — S 580 4MATIC AWD

With 90 active listings, the S 580 4MATIC AWD is the clear volume leader in the lineup.

Browse S 580 4MATIC AWD listings

Best Budget Option — S 500 4MATIC AWD

At $55,168 avg market price — below the lineup median of $55,168 — it's the most accessible entry point.

Browse S 500 4MATIC AWD listings

Best for Fuel Economy — S 500 4MATIC AWD

With an impressive 21/30 MPG/MPGe, the S 500 is the most fuel-efficient option in the lineup.

Browse S 500 4MATIC AWD listings

These recommendations are based on CarGurus' proprietary market data from October 15, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz S-Class cost?

Prices have softened 11.52% compared to this time last year, making it a favorable time to shop this model year.

There are 1,117 listings available, which gives you a meaningful amount of inventory to compare.

Is the 2022 Mercedes-Benz S-Class a good car?

Yes — the 2022 Mercedes-Benz S-Class earns a 4.5/5 user rating and an 8.67/10 expert rating. The model scores 9/10 across Look and feel, Form and function, Technology, and Safety.

It is aimed at you if you want a full-size luxury sedan that feels like executive transportation, with a stylish design, great ride quality, and premium interior materials. The cabin and tech presentation are central to its appeal, and the car’s flagship mission comes through in the upscale materials and advanced features.

The main trade-offs are the potentially polarizing design and the high price tag. If you value refinement, luxury, and a deeply polished driving experience more than bargain pricing, this model fits that brief well.

33.8% of listings are priced as good or great deals, which suggests there are still some attractive opportunities if you shop carefully.

Is the 2022 Mercedes-Benz S-Class reliable?

Owners rate it 4.5/5, a strong signal of long-term satisfaction.

The 2022 S-Class is built around a 48-volt mild-hybrid setup, and the powertrain is described as seamless, quick, and well suited to both commuting and weekend driving. The expert review also emphasizes that the car handles smoothly, brakes confidently, and delivers the kind of refinement you expect from a flagship sedan.

Mercedes also frames the car as a highly refined executive sedan with strong overall excellence, which supports the case for long-term ownership confidence. The main used-buyer risk is cost: when a luxury flagship is this complex and expensive, repairs and upkeep can be more consequential than on a mainstream sedan.

What should I look for when buying a used 2022 Mercedes-Benz S-Class?

Accident-free inventory is solid at 87.4% — always verify the vehicle history report.

You should start with the vehicle history report, then prioritize a thorough pre-purchase inspection so you can confirm the car’s condition and equipment. Pay close attention to signs of prior damage, wheel and tire condition, and whether the luxury features and driver-assistance systems work as intended.

Key things to evaluate:

• Trim level: The S500 and S580 both bring a high-end feature set, but the S500 starts at a lower price and is the better value if you want the flagship experience without stretching to the top end. The S580 adds the V8 and a higher starting price, so it suits you if you want more engine output and are willing to pay for it.
• Powertrain: You get a turbocharged 3.0-liter inline-six with EQ Boost in the S500 or a twin-turbo 4.0-liter V8 with EQ Boost in the S580. Both use a nine-speed automatic and standard all-wheel drive, and both are tuned for smooth, quick, refined performance.
• Safety package: The car includes active distance assist Distronic adaptive cruise control with route-based speed adaptation, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic function and turn-off function, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication. Rear-passenger airbags and a rear-seat belt bag are available, so check whether the example you’re considering has the rear-seat protection you want.
• Infotainment: The cabin centers on a 12.8-inch OLED touchscreen with the latest MBUX system, paired with a 12.3-inch digital instrument panel. Wireless smartphone integration is not mentioned, but the car does offer augmented video for navigation, and an available augmented reality head-up display adds another layer of guidance.
• Fuel efficiency: The S500 is rated at up to 21 mpg city/30 mpg highway/24 mpg combined, while the S580 is rated at 16 mpg city/25 mpg highway/19 mpg combined.

Which 2022 Mercedes-Benz S-Class trim should I buy?

The 2022 Mercedes-Benz S-Class is offered in 5 trim levels: S500 4Matic Luxury Line, S500 4Matic AMG Line, S580 4Matic Luxury Line, S580 4Matic AMG Line, S580 4Matic Executive Line.

Here's the short version:

• S500 4Matic Luxury Line: This is the entry point to the lineup, and it gives you the core S-Class experience at the lowest starting price. It suits you if you want the flagship sedan’s comfort, tech, and refinement without paying for the more expensive V8 or appearance upgrades.
• S500 4Matic AMG Line: This version adds a sportier visual treatment and was the test vehicle’s trim, making it the best-value choice if you want a more distinctive look without moving up to the V8. It’s the trim to focus on if you want the strongest balance of price, equipment, and everyday luxury.
• S580 4Matic Luxury Line: This trim is for you if you want the V8 powertrain and the standard luxury presentation. It makes sense if performance matters more than value and you want the more powerful engine without extra appearance packaging.
• S580 4Matic AMG Line: This trim combines the V8 with the sportier AMG appearance treatment. Choose it if you want the stronger engine and a more aggressive look in one package.
• S580 4Matic Executive Line: This is the most upscale trim in the lineup and is the one to consider if you want the most premium rear-seat and executive-oriented presentation. It fits best if you plan to use the S-Class as a true chauffeur-style luxury sedan.

The safety content also notes available rear-passenger airbags and a rear-seat belt bag, so check whether those executive-focused features are included on the specific car you’re considering.

Is now a good time to buy a used 2022 Mercedes-Benz S-Class?

This is a moderate, selective buyer’s market, so you can shop with some leverage if you’re patient and compare listings carefully.

• Deal availability: 33.8% of listings are priced as good or great deals.
• Inventory: There are 1,117 listings available.
• Price trend: Prices have softened 11.52% compared with last year.
• Clean inventory: 87.4% of listings are accident-free.

If you find a listing below $61,862, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz S-Class's resale value?

The current average of $61,862 sits slightly below last year's $69,920.

That decline suggests the market has already adjusted downward, which can help you buy at a more favorable point in the cycle. For a future seller, that also means resale value may depend heavily on condition, mileage, and equipment rather than just model-year prestige.

Because the S-Class sits in the luxury flagship segment, buyers will still expect a well-kept example with strong presentation and complete features. If you maintain it carefully and keep the history clean, you should have a better chance of preserving demand when it’s time to sell.

Vehicles with strong owner satisfaction ratings, like this model year's 4.5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz S-Class safe?

The 2022 Mercedes-Benz S-Class earns a 9/10 safety score from our experts.

Mercedes equips the S-Class with a long list of standard and available driver-assistance features, including active distance assist Distronic adaptive cruise control with route-based speed adaptation, active stop-and-go assist, active steering assist with active emergency stop assist and active lane-change assistant, active brake assist with cross-traffic function and turn-off function, active speed limit assist with traffic sign assist, active blind-spot assist with exit warning, active lane-keeping assist, active parking assist with Parktronic, Pre-Safe Plus with Pre-Safe Sound, Pre-Safe Impulse Side, and car-to-x communication.

The car also includes Magic Vision Control, which is designed to meter windshield spray more precisely based on conditions. For rear-seat passengers, available rear-passenger airbags and a rear-seat belt bag add another layer of protection.

Should I buy a 2022 Mercedes-Benz S-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 33.8% of listings are priced as good or great deals.
• Accident-free inventory is solid at 87.4% — always verify the vehicle history report.
• Price trend: Prices have softened 11.52% compared with last year.
• Owners rate it 4.5/5 — a strong satisfaction signal.
• It combines a refined mild-hybrid powertrain with a flagship cabin and advanced driver assistance.

Consider the 2021 if:

• At $57,649, the 2021 costs less than the current year's $61,862 average.
• It brings a major redesign with new powertrains and a more sophisticated infotainment system.

Consider the 2023 if:

• At $77,069, the 2023 costs more than the current year's $61,862 average.
• It adds a plug-in hybrid powertrain with electric-only driving capability.

The bottom line: If you want the best balance of price, luxury, and modern tech, the 2022 is the smart default. If your priority is saving money, the 2021 is the better value play. If you want the newer plug-in hybrid direction and can justify the higher cost, the 2023 is the upgrade path.

These recommendations are based on CarGurus' proprietary market data from October 20, 2026, CarGurus experts' opinions, and generative AI.