Used 2022 Mercedes-Benz E-Class for Sale near Laurel, MS
116 results
CarGurus Analysis:
2022 Mercedes-Benz E-Class
With 1,082 currently listed for sale and an average price of $41,560.00, 32.3% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
85.2% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class offers a luxurious convertible option, advanced safety features, and a sophisticated infotainment system with MBUX technology.
CarGurus Analysis: 2022 Mercedes-Benz E-Class
overall

Summary
With 1,082 currently listed for sale and an average price of $41,560.00, 32.3% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
85.2% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class offers a luxurious convertible option, advanced safety features, and a sophisticated infotainment system with MBUX technology.
Why it stands out
The 2022 Mercedes-Benz E-Class is notable for its luxurious design and versatility, available in multiple body styles including coupe, convertible, sedan, and station wagon. Following a refresh in 2021, the E-Class lineup primarily features turbocharged four-cylinder and six-cylinder engines, streamlining its performance offerings while still ensuring robust acceleration and driving dynamics, particularly with models like the AMG-tuned E53. It boasts a sophisticated interior filled with high-quality materials and cutting-edge technology, epitomized by the MBUX infotainment system that integrates seamlessly with the vehicle's operation. Standard safety features such as forward collision warning and automatic emergency braking make this vehicle not only stylish but also safe, reinforcing its appeal as a high-end option for those seeking comfort and performance in the luxury segment.
Other model years to consider
- Average price: $30,396.00
- Good/great deal percentage: 33.1%
- User rating: 5 / 5
- Total listings: 1,016
- Average price: $23,345.00
- Good/great deal percentage: 32.3%
- User rating: 4.76 / 5
- Total listings: 1,430
- Average price: $18,873.00
- Good/great deal percentage: 31.7%
- User rating: 4.78 / 5
- Total listings: 1,355
This analysis is based on CarGurus' proprietary market data from May 4, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles

The Best Family Sedans of 2026
Advanced safety features that were once exclusive to luxury cars are now standard on many family sedans. And while sedans might not have the space of an SUV or a minivan, they do have efficiency on their side. Here are our top 10.

2026 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Sitting squarely in the midsize luxury sedan segment, the 2026 Mercedes-Benz E-Class competes with the BMW 5 Series, the Audi A6, and the Lexus ES.

2025 Mercedes-Benz E-Class Pricing, Specs, and Release Date
Thoroughly updated last year, the Mercedes-Benz E-Class returns for 2025 with added safety equipment, a new entry-level trim, and an AMG E 53 Hybrid version designed to deliver equal parts performance and efficiency.
5.0 Overall rating
Filter by rating
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 6, 2025
The E-class is the midsize line of Mercedes cars, so it’s fine for all sizes except for very tall and large people. The new inline six cylinder is my favorite engine because it has plenty of power and is fuel efficient. Overall, the quality is here and has been for years.
Anonymous
Reviewed a 2022 Mercedes-Benz E-Class on Jul 12, 2024
Great value. 39K with 14K miles and in great condition with premium package. Took it to the Mercedes dealer for inspection and they said it was in great shape (tires, brakes, belts, filters, oil, fluid level, electronics, and even spark plugs). The interior was in pristine condition and the exterior is just as perfect.
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 7, 2025
The E-class Mercedes Is the midsize car segment, and is large enough for many people who are not over 6’ 6” or more than 380 pounds in my estimation. Quality is noticed in interior seating and fit and finish. The relatively new Inline six cylinder engine has enough power with above average fuel economy. Other engines are available in four cylinder and eight cylinder variants.
Bill F
Reviewed a 2022 Mercedes-Benz E-Class on Jan 7, 2023
First class, quality material and build! You know maintenance is expensive going into it, but it is what it is.
2022 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 Cabriolet RWD | $73,250 |
| E 450 4MATIC Coupe AWD | $68,600 |
| AMG E 53 Coupe 4MATIC | $77,600 |
| E 450 Coupe RWD | $66,100 |
| E 450 4MATIC Sedan AWD | $62,750 |
| AMG E 53 Sedan 4MATIC | $75,000 |
| E 350 4MATIC | $57,450 |
| E 350 RWD | $54,950 |
2022 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz E-Class prices has changed over time.
See more price trends







