Used 2021 Mercedes-Benz S-Class for Sale nearEl Paso, TX
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black (Charcoal)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,245
- Stock #:
- J261102
- VIN:
- W1KUG6EB6LA555551


Sponsored by Jaguar Land Rover El Paso
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
41,245 mi
$40,346
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,930
- Stock #:
- NA153832
- VIN:
- W1K6G7GB0NA153832

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
16,930 mi
$80,676
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 37,878
- Stock #:
- 104782
- VIN:
- W1K6G6DBXNA104782

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
37,878 mi
$49,956
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 62,114
- Stock #:
- 68849
- VIN:
- W1K6G7GB8NA068849

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
62,114 mi
$53,342
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 37,431
- Stock #:
- 148268T
- VIN:
- W1K6G7GB5NA148268

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
37,431 mi
$64,676
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 68,006
- Stock #:
- MA049575
- VIN:
- W1K6G7GB3MA049575

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
68,006 mi
$50,544
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 31,770
- Stock #:
- M913541
- VIN:
- W1K6G7GB6NA163362

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,770 mi
$72,048
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Coupe
- Doors:
- 2 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 9,810
- Stock #:
- TLA041798
- VIN:
- WDDXJ8GB2LA041798

2020 Mercedes-Benz S-Class
S 560 4MATIC Coupe AWD
9,810 mi
$74,714
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Cashmere White Magno
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 33,081
- Stock #:
- 0428BL
- VIN:
- W1K6G6DB9NA104837

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
33,081 mi
$58,997
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 46,030
- Stock #:
- NA104107
- VIN:
- W1K6G7GB3NA104107

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
46,030 mi
$67,577
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black (Charcoal)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,245
- Stock #:
- J261102
- VIN:
- W1KUG6EB6LA555551

2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
41,245 mi
$40,346
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 16,201
- Stock #:
- 70270273
- VIN:
- W1K6G6DBXNA117824

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
16,201 mi
$66,297
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,489
- Stock #:
- I8151
- VIN:
- W1K6G6DB7NA128151

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
30,489 mi
$54,195
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 114 currently listed for sale near El Paso, TX and an average price of $64,998, 37.7% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars and CarGurus experts gave it a 7.5 / 10.
81.6% of 2021 S-Class models on CarGurus are accident free.
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- [040] Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Black
- Transmission:
- Automatic
- Mileage:
- 59,782
- Stock #:
- 426042
- VIN:
- WDDUG8JB7LA522009
![[040] Black 2020 Mercedes-Benz S-Class Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/06/01/22/54/2020_mercedes-benz_s-class-pic-3335666247717155142-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
59,782 mi
$65,730
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,980
- Stock #:
- 019947
- VIN:
- W1K6G7GB7MA019947

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
52,980 mi
$58,042
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,202
- Stock #:
- NA141703
- VIN:
- W1K6G7GB6NA141703

2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
16,202 mi
$72,112
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,200
- Stock #:
- 023555
- VIN:
- W1K6G7GBXMA023555

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
48,200 mi
$58,939
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 39,863
- Stock #:
- MA042471
- VIN:
- W1K6G7GB0MA042471

2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
39,863 mi
$58,792
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$49,610
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,371
- Stock #:
- STK156393
- VIN:
- W1K6G6DB6NA156393

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,371 mi
$60,258
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,675
- Stock #:
- L13119
- VIN:
- W1K6G6DB5NA092640

2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
35,675 mi
$53,450
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- [799] MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 51,622
- Stock #:
- 426048
- VIN:
- W1K6G7GB7NA156985
![[799] MANUFAKTUR Diamond White Metallic 2022 Mercedes-Benz S-Class Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/06/19/02/30/2022_mercedes-benz_s-class-pic-242312685585077151-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
51,622 mi
$64,730
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray (Selenite Grey M)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 42,809
- Stock #:
- 522209H
- VIN:
- WDDUG8GB5LA522209

2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
42,809 mi
$41,620
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall

Summary
With 114 currently listed for sale near El Paso, TX and an average price of $64,998, 37.7% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars and CarGurus experts gave it a 7.5 / 10.
81.6% of 2021 S-Class models on CarGurus are accident free.
Why it stands out
Mercedes gives its flagship an overhaul, and the 2021 Mercedes-Benz S-Class is built to reinforce exactly why the nameplate sits at the top of the brand’s hierarchy. It has long served as a technological showcase, and Mercedes has used the redesigned sedan to introduce innovations that later trickled down to mainstream vehicles. For buyers, that means the appeal is not just prestige and luxury, but also the sense that the car is meant to showcase the brand’s most advanced ideas.
The 2021 S-Class also arrives with a more sophisticated infotainment system, new powertrains, and more aerodynamic bodywork. It launches in two configurations, both with 4Matic all-wheel drive and EQ Boost mild-hybrid systems: the S500 4Matic uses a six-cylinder engine, while the S580 4Matic uses a V8. That combination of comfort, impressive technology, and strong performance makes it especially compelling, though its high price is a clear drawback. Owners also praise its luxurious feel and advanced technology, while some note issues with the run-flat tires.
Other model years to consider
- 2020 Mercedes-Benz S-Class
- Average price: $39,959
- Good/great deal percentage: 35.6%
- User rating: 4.9 / 5
- Total listings: 87
This analysis is based on CarGurus' proprietary market data from September 28, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends2021 Mercedes-Benz S-Class Pricing Analysis: El Paso, TX Market Report
Pricing by Trim Packages
Key Insights
- Volume Leader: The S 580 Sedan 4MATIC dominates the market with 22 listings, indicating strong demand and availability.
- Premium Spread: The Maybach S 580 Sedan 4MATIC has the highest MSRP at $184,900, reflecting its luxury positioning within the lineup.
- Drivetrain Effect: All trims feature AWD, which may enhance their appeal in varying driving conditions, contributing to the overall inventory levels.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| S 580 Sedan 4MATIC | 22 | $116,300 | AWD | 4.0L 496 hp V8 |
| Maybach S 580 Sedan 4MATIC | 5 | $184,900 | AWD | 4.0L 496 hp V8 |
| S 500 Sedan 4MATIC | 1 | $109,800 | AWD | 3.0L 429 hp I6 |
These recommendations are based on CarGurus' proprietary market data from September 30, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
How much does the 2021 Mercedes-Benz S-Class cost?
| Metric | Value |
|---|---|
| Current Average Price | $58,597 |
| Year-Round Low | $58,587 |
| Year-Round High | $65,001 |
| Average Price a Year Ago | $65,005 |
| Change vs. Last Year | −9.86% |
Prices have softened 9.86% compared to this time last year, making it a favorable time to shop this model year.
There are 748 listings available, which gives you a reasonable amount of inventory to compare.
Is the 2021 Mercedes-Benz S-Class a good car?
Generally — you’re looking at a 4/5 user-rated flagship with an expert score of 7.5/10. The model scores 9/10 across Performance and Technology.
Owners consistently praise the luxurious feel, advanced technology, and strong performance. The review summary also points to thrilling acceleration and enjoyable handling, which fits the S-Class’s role as a high-end executive sedan.
The main trade-off is the high price, and the expert review also notes that some competitors are slightly quicker. For you, that means the S-Class makes the most sense if you value comfort, tech, and prestige more than outright value or bargain performance.
Good and great deals account for 33.4% of listings, so there are still some attractive opportunities if you shop carefully.
Is the 2021 Mercedes-Benz S-Class reliable?
Owners rate it 4/5, a solid signal of long-term satisfaction.
The owner summary points to a car that feels luxurious and advanced while still delivering strong performance, and it also suggests the experience is generally positive enough that most owners are impressed. The expert review adds that the mild-hybrid setup helps with efficiency through electric assist and more aggressive stop/start behavior, which supports everyday dependability.
Mercedes also backs the car with a four-year, 50,000-mile basic warranty and a four-year, 50,000-mile powertrain warranty. Even so, the S-Class is complex enough that long-term ownership can become expensive if maintenance is neglected.
What should I look for when buying a used 2021 Mercedes-Benz S-Class?
Accident-free inventory is solid at 82% — always verify the vehicle history report.
You should still run a history report on every candidate, even if the listing looks clean. Prioritize a pre-purchase inspection that checks the tires, suspension, electronics, and driver-assistance systems, since this is a highly complex luxury sedan. Focus on overall condition and maintenance records, because the car’s sophistication can make neglected examples costly to sort out.
Key things to evaluate:
- Trim level: The S-Class comes standard with 19-inch wheels, while 20-inch and 21-inch wheels are optional. The cabin centers on the infotainment touchscreen and digital instrument cluster, and the test car’s AMG Line package added 20-inch wheels. That makes the better-equipped version the one to target if you want the full flagship feel.
- Powertrain: The S500 4Matic uses a 3.0-liter turbocharged inline-six with 429 horsepower and 384 pound-feet of torque, while the S580 4Matic uses a 4.0-liter twin-turbo V8 with 496 hp and 516 lb-ft. Both use a nine-speed automatic, EQ Boost mild-hybrid assistance, and all-wheel drive.
- Safety package: Standard driver-assistance features include adaptive cruise control with stop-and-go, automated lane centering, automatic emergency braking, forward-collision warning, blind-spot monitoring, lane-keep assist, lane-change assist, traffic-sign recognition, a driver-attention monitor, and a 360-degree camera system. The S-Class also includes an industry-first rear-passenger airbag.
- Infotainment: Standard equipment includes a 12.3-inch digital instrument cluster and a 12.8-inch OLED central touchscreen, plus wireless Apple CarPlay and Android Auto. The system also supports over-the-air-style modern connectivity through an updated MBUX setup, and available rear-seat tech adds a pair of 11.6-inch touchscreens and a 7-inch tablet.
- Fuel efficiency: The expert review says EPA fuel-economy ratings weren’t available yet, but it recorded 22.4 mpg over about 300 miles of driving.
Which 2021 Mercedes-Benz S-Class trim should I buy?
The 2021 Mercedes-Benz S-Class is offered in 2 trim levels: S500 4Matic, S580 4Matic.
Here's the short version:
- S500 4Matic: This is the better-value choice if you want the S-Class experience without paying for the V8. It still gives you the 429-horsepower inline-six, EQ Boost mild-hybrid assistance, all-wheel drive, and the same core luxury and tech foundation.
- S580 4Matic: This is the one to choose if you want the strongest performance and the most effortless flagship feel. The V8’s 496 horsepower and 516 pound-feet of torque make it the more compelling pick for buyers who want the top-end powertrain.
The standard safety package is broad, and the car’s driver-assistance systems are a major part of its appeal.
Is now a good time to buy a used 2021 Mercedes-Benz S-Class?
This is a moderate market for selective buyers, so you can shop with some leverage if you’re patient.
- Deal availability: 33.4% of listings are priced as good or great deals.
- Inventory: There are 748 listings available.
- Price trend: Prices have softened 9.86% compared with last year.
- Clean inventory: 82.0% of listings are accident-free.
If you find a listing below $58,587, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2021 Mercedes-Benz S-Class's resale value?
The current average of $58,597 sits slightly below last year's $65,005.
That decline suggests the market has already adjusted downward, which can help you as a buyer today but may limit upside if you plan to resell soon. If you buy at the right price and keep the car in excellent condition, you’ll be better positioned to preserve value than someone who pays near the top of the range.
Vehicles with solid owner satisfaction ratings, like this model year's 4/5, tend to retain buyer demand, which supports resale value over time.
Is the 2021 Mercedes-Benz S-Class safe?
The S-Class does get a plethora of safety features, including an industry-first rear-passenger airbag.
It earns a 7/10 safety score from our experts.
Standard driver-assistance features include adaptive cruise control with stop-and-go functionality, automated lane centering, automatic emergency braking, forward-collision warning, blind-spot monitoring, lane-keep assist, lane-change assist, traffic-sign recognition, a driver-attention monitor, and a 360-degree camera system. Mercedes also says traffic-sign recognition can detect stop signs and red lights, while lane-keep assist can read road edges and lets you adjust sensitivity.
Crash-test ratings from NHTSA and IIHS aren’t available, so you’ll be relying more on the car’s extensive standard safety tech than on published test results.
Should I buy a 2021 Mercedes-Benz S-Class or consider a different year?
If you're weighing the 2021 against nearby model years, here's how to think about it:
Choose the 2021 if:
- 33.4% of listings are priced as good or great deals.
- Accident-free inventory is solid at 82% — always verify the vehicle history report.
- Price trend: Prices have softened 9.86% compared with last year.
- Owners rate it 4/5 — a solid satisfaction signal.
- It introduces a redesigned cabin, new powertrains, and more advanced infotainment.
Consider the 2022 if:
- At $63,211, the 2022 costs more than the current year's $58,597 average.
- It keeps the same flagship formula with updated model-year pricing and a slightly newer market position.
The bottom line: If you want the better value, the 2021 is the smarter buy because prices have eased and the model already delivers the full redesign. If you’re willing to spend more for a newer model year, the 2022 is the cleaner alternative, but price-sensitive buyers should focus on the 2021’s stronger value proposition.
These recommendations are based on CarGurus' proprietary market data from September 29, 2026, CarGurus experts' opinions, and generative AI.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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