Used 2022 Mercedes-Benz GLS for Sale nearColumbia, SC
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Espresso Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 71,670
- Stock #:
- S1978
- VIN:
- 4JGFF5KE6NA675329


Sponsored by Columbia City Cars
2022 Mercedes-Benz GLS
450 4MATIC
71,670 mi
$41,349
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 18 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 40,815
- Stock #:
- 18037
- VIN:
- 4JGFF8GE9MA396191

Sponsored Listing
2021 Mercedes-Benz GLS
580 4MATIC
40,815 mi
$53,399
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 47,409
- Stock #:
- XH9086
- VIN:
- 4JGFF5KE9NA661831

-$2,564
Sponsored Listing
2022 Mercedes-Benz GLS
450 4MATIC
47,409 mi
$50,353
$47,789
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 47,409
- Stock #:
- XH9086
- VIN:
- 4JGFF5KE9NA661831

-$2,564
2022 Mercedes-Benz GLS
450 4MATIC
47,409 mi
$50,353
$47,789
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 35,731
- Stock #:
- PA852287
- VIN:
- 4JGFF5KEXPA852287

2023 Mercedes-Benz GLS
450 4MATIC
35,731 mi
$56,995
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Selenite Grey Metallic)
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,780
- Stock #:
- PA876611
- VIN:
- 4JGFF5KE3PA876611

2023 Mercedes-Benz GLS
450 4MATIC
25,780 mi
$58,195
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,816
- Stock #:
- 7538
- VIN:
- 4JGFF5KE8PA900613

2023 Mercedes-Benz GLS
450 4MATIC
61,816 mi
$46,893
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Polar White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,140
- Stock #:
- 25837B
- VIN:
- 4JGFF5KE1NA762393

2022 Mercedes-Benz GLS
450 4MATIC
21,140 mi
$52,474
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Espresso Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,913
- Stock #:
- SX1873
- VIN:
- 4JGFF5KE8NA610207

2022 Mercedes-Benz GLS
450 4MATIC
32,913 mi
$52,287
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 16 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 41,137
- Stock #:
- 475445
- VIN:
- 4JGFF8KE5MA475445

2021 Mercedes-Benz GLS
AMG GLS 63 4MATIC AWD
41,137 mi
$70,715
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 59,994
- Stock #:
- NA609734
- VIN:
- 4JGFF5KE4NA609734

2022 Mercedes-Benz GLS
450 4MATIC
59,994 mi
$44,802
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 33,797
- Stock #:
- S18585XA
- VIN:
- 4JGFF5KE0PA936120

2023 Mercedes-Benz GLS
450 4MATIC
33,797 mi
$55,252
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White Bright
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- Automatic
- Mileage:
- 49,829
- Stock #:
- PA032062A
- VIN:
- 4JGFF5KE8NA671329

2022 Mercedes-Benz GLS
450 4MATIC
49,829 mi
$48,580
CarGurus Analysis:
2022 Mercedes-Benz GLS
With 172 currently listed for sale near Columbia, SC and an average price of $44,950.00, 49.4% of 2022 Mercedes-Benz GLSs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz GLS 5 / 5 stars and CarGurus experts gave it a 7.33 / 10.
85.5% of 2022 GLS models on CarGurus are accident free.
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 16 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 63,709
- Stock #:
- A10509
- VIN:
- 4JGFF8KE4MA356057

2021 Mercedes-Benz GLS
AMG GLS 63 4MATIC AWD
63,709 mi
$57,694
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 60,278
- Stock #:
- 824083
- VIN:
- 4JGFF5KE1NA824083

2022 Mercedes-Benz GLS
450 4MATIC
60,278 mi
$41,978
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,654
- Stock #:
- E2663A
- VIN:
- 4JGFF5KE7NA630724

2022 Mercedes-Benz GLS
450 4MATIC
44,654 mi
$43,701
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,703
- Stock #:
- PA938533
- VIN:
- 4JGFF5KE2PA938533

2023 Mercedes-Benz GLS
450 4MATIC
34,703 mi
$56,809
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,976
- Stock #:
- PM6866A
- VIN:
- 4JGFF5KE5NA704853

2022 Mercedes-Benz GLS
450 4MATIC
36,976 mi
$51,426
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 16 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 79,159
- Stock #:
- 12422
- VIN:
- 4JGFF8KE2MA400122

2021 Mercedes-Benz GLS
AMG GLS 63 4MATIC AWD
79,159 mi
$55,205
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Black)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 53,121
- Stock #:
- 808224
- VIN:
- 4JGFF5KE1NA808224

2022 Mercedes-Benz GLS
450 4MATIC
53,121 mi
$45,966
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cardinal Red
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Beige)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 48,700
- Stock #:
- 9495A
- VIN:
- 4JGFF5KE5PA953494

2023 Mercedes-Benz GLS
450 4MATIC
48,700 mi
$51,773
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Espresso Brown/Black
- Transmission:
- Automatic
- Mileage:
- 36,339
- Stock #:
- STK924813
- VIN:
- 4JGFF5KE4PA924813

2023 Mercedes-Benz GLS
450 4MATIC
36,339 mi
$55,892
- Year:
- 2023
- Make:
- Mercedes-Benz
- Model:
- GLS
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,176
- Stock #:
- PA954949
- VIN:
- 4JGFF5KE3PA954949

Sponsored Listing
2023 Mercedes-Benz GLS
450 4MATIC
37,176 mi
$57,995
CarGurus Analysis: 2022 Mercedes-Benz GLS
overall

Summary
With 172 currently listed for sale near Columbia, SC and an average price of $44,950.00, 49.4% of 2022 Mercedes-Benz GLSs for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz GLS 5 / 5 stars and CarGurus experts gave it a 7.33 / 10.
85.5% of 2022 GLS models on CarGurus are accident free.
Why it stands out
The 2022 Mercedes-Benz GLS sits at the top of Mercedes’ luxury SUV range and serves as the brand’s flagship SUV. It is the biggest SUV Mercedes offers, and its three-row layout gives it the kind of size and utility that help define the model. Mercedes also positions it as the SUV equivalent of the S-Class sedan, which underscores its role as the brand’s most upscale large SUV.
For 2022, Mercedes withdrew most of its V8 models from the United States, leaving only the base six-cylinder GLS 450 4Matic model. That makes this version of the GLS notable for being the only one available at the time of the review. Even so, the model still stands out for its stylish design, powerful engine, and spacious cabin.
The tradeoffs are worth noting. The 2022 Mercedes-Benz GLS was criticized for poor ride quality, poor ergonomic design, and the fact that advanced safety features are not standard. Those drawbacks keep it from feeling flawless, but for buyers who want a large, luxurious, and highly capable three-row SUV, the GLS remains distinctive.
Other model years to consider
- Average price: $23,498.00
- Good/great deal percentage: 50.7%
- User rating: 4.8 / 5
- Total listings: 213
- Average price: $43,974.00
- Good/great deal percentage: 48.4%
- User rating: 4.67 / 5
- Total listings: 157
- Average price: $30,250.00
- Good/great deal percentage: 51.6%
- User rating: 4.5 / 5
- Total listings: 186
This analysis is based on CarGurus' proprietary market data from August 18, 2026, CarGurus experts' opinions, and generative AI.
5.0 Overall rating
Filter by rating
rick j
Reviewed a 2022 Mercedes-Benz AMG GLS 63 4MATIC on Aug 23, 2022
This is an amazing vehicle. It has comfort and class plus power. Love it!
Robert S
Reviewed a 2022 Mercedes-Benz GLS on Jun 7, 2022
Major improvement over prior models … driver assist substantially better
Jim A
Reviewed a 2022 Mercedes-Benz GLS on Jul 20, 2023
Cool looking, Mercedes quality, spacious, comfortable, excellent performance and dependable.
2022 Mercedes-Benz GLS Trims
| Trim type | MSRP |
|---|---|
| 580 4MATIC | $101,250 |
| AMG GLS 63 4MATIC | $135,400 |
| 450 4MATIC | $77,850 |
| 600 Mercedes-Maybach 4MATIC | $165,100 |
2022 Mercedes-Benz GLS Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz GLS prices has changed over time.
See more price trends2022 Mercedes-Benz GLS Pricing Analysis: Columbia, SC Market Report
Pricing by Nearby Locations
Market Area: Columbia, SC
Key Insights
- Highest Prices in Spartanburg: The average price in Spartanburg, SC ($47,498) is the highest among nearby cities, indicating a potential demand for luxury vehicles in that area.
- Lowest Prices in Orangeburg and Sumter: Both Orangeburg and Sumter have the lowest average price at $45,142, suggesting a more price-sensitive market or higher inventory turnover.
- Stable Pricing Across Cities: The average prices across cities show minimal variation, with most cities clustering around the $45,000 to $48,000 range, indicating a stable market for the GLS.
City-Level Pricing
| City | Total Listings | Avg Price |
|---|---|---|
| Spartanburg, SC | 176 | $47,498 |
| Greenville, SC | 177 | $47,498 |
| Charlotte, NC | 171 | $47,881 |
| Anderson, SC | 175 | $48,991 |
| Lancaster, SC | 174 | $44,086 |
| Orangeburg, SC | 171 | $45,142 |
| Sumter, SC | 172 | $45,142 |
Pricing by Trim Packages
Key Insights
- Most Common Trim: The 450 4MATIC is the most common trim with 422 listings, indicating strong demand for this model.
- Price Range Across Trims: The trims range from $77,850 for the 450 4MATIC to $165,100 for the 600 Mercedes-Maybach 4MATIC, highlighting a significant premium for luxury features.
- AWD Dominance: All trims are AWD, reflecting a market preference for all-weather capability, which is typical for luxury SUVs.
Trim-Level Details
| Trim | Listings | MSRP | Drivetrain | Engine |
|---|---|---|---|---|
| 450 4MATIC | 422 | $77,850 | AWD | 3.0L 362 hp I6 |
| 580 4MATIC | 55 | $101,250 | AWD | 4.0L 483 hp V8 |
| AMG GLS 63 4MATIC | 50 | $135,400 | AWD | 4.0L 603 hp V8 |
| 600 Mercedes-Maybach 4MATIC | 57 | $165,100 | AWD | 4.0L 550 hp V8 |
Pricing Analysis by Model Year
Key Insights
- Significant New-Car Premium: The 2026 model is priced at $105,990, which is approximately 17.5% above its MSRP, indicating strong demand for the latest model.
- Depreciation Trends: The 2021 model shows a steep depreciation of ~42.1% from its original MSRP, reflecting the rapid value loss typical for luxury vehicles.
- Best Value Year: The 2019 model offers the best value with an average price of $30,250, down ~56.9% from its MSRP, making it an attractive option for budget-conscious buyers.
Model Year Pricing
| Model Year | Original MSRP | Avg Price | Price vs MSRP |
|---|---|---|---|
| 2026 Mercedes-Benz GLS | $90,250 | $105,990 | +17.5% |
| 2021 Mercedes-Benz GLS | $76,000 | $43,974 | -42.1% |
| 2019 Mercedes-Benz GLS | $70,150 | $30,250 | -56.9% |
| 2018 Mercedes-Benz GLS | $69,550 | $23,498 | -66.3% |
These recommendations are based on CarGurus' proprietary market data from August 20, 2026, CarGurus experts' opinions, and generative AI.
How much does the 2022 Mercedes-Benz GLS cost?
| Metric | Value |
|---|---|
| Current Average Price | $48,712 |
| Year-Round Low | $48,683.95 |
| Year-Round High | $56,417.32 |
| Average Price a Year Ago | $56,420 |
| Change vs. Last Year | −13.66% |
Prices have softened 13.66% compared to this time last year, making it a favorable time to shop this model year.
There are 926 listings available, which gives you a meaningful amount of inventory to compare.
If you find a listing below $48,683.95, that's toward the low end of the year-round range and worth acting on quickly.
Is the 2022 Mercedes-Benz GLS a good car?
Yes — the 5/5 user rating points to strong owner satisfaction, and the expert rating is 7.33/10.
The standout strength is Look and feel at 9/10.
The 2022 GLS sits at the top of Mercedes’ luxury SUV range and is positioned as the brand’s flagship SUV, with a three-row layout that emphasizes size and utility. It also serves as the SUV equivalent of the S-Class sedan, which helps explain its upscale mission.
The trade-offs are clear: the expert review calls out poor ride quality and poor ergonomic design, and advanced safety features are not standard. For you, that means the GLS makes the most sense if you want a large, luxurious, highly capable three-row SUV and can live with some comfort and usability compromises.
33.7% of listings are priced as good or great deals, so there is still room to shop selectively.
Is the 2022 Mercedes-Benz GLS reliable?
Owners rate it 5/5, a strong signal of long-term satisfaction.
The GLS is built around a 3.0-liter turbocharged inline six with mild-hybrid assistance, and the expert review says the six-cylinder provides more than enough muscle for this big SUV. It also notes that the inline-six layout is inherently smoother than a V6, which is a good sign for refinement in daily use.
Mercedes’ EQ Boost system also helps the engine start and stop more aggressively while reducing the engine’s workload. On the ownership side, the GLS comes with a four-year, 50,000-mile basic warranty and powertrain warranty, which helps cover early-life risk.
For used buyers, the main long-term concern is less about outright powertrain weakness and more about whether a heavily optioned luxury SUV has been maintained carefully.
What should I look for when buying a used 2022 Mercedes-Benz GLS?
Accident-free inventory is solid at 86.1% — always verify the vehicle history report.
Start with the history report so you can confirm accident status and spot any major repairs or title issues. Then prioritize a thorough inspection of the suspension, interior controls, and electronics, since the review points to ride quality and ergonomics as weak spots. You should also pay close attention to how the vehicle feels over bumps and whether the cabin controls are intuitive in real-world use.
Key things to evaluate:
- Trim level: In base GLS 450 form, the cabin is more subdued than flashier rivals, and the test vehicle lacked reclining seats. The interior still felt luxurious, but it was fairly basic by GLS standards.
- Powertrain: The GLS 450 uses a 3.0-liter turbocharged inline six with a nine-speed automatic and EQ Boost mild-hybrid assistance. It makes 362 horsepower and 369 pound-feet of torque, with an additional 21 hp and 184 lb-ft available in short bursts.
- Safety package: Standard equipment includes forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. Adaptive cruise control, lane-keep assist, and second-row side airbags cost extra.
- Infotainment: The standard MBUX setup includes a 12.3-inch touchscreen, a 12.3-inch digital instrument cluster, Bluetooth, Apple CarPlay/Android Auto, navigation, SiriusXM, and natural-language voice recognition. A head-up display is optional.
- Fuel efficiency: EPA ratings are 20 mpg combined, 18 mpg city, and 24 mpg highway.
Which 2022 Mercedes-Benz GLS trim should I buy?
The 2022 Mercedes-Benz GLS is offered in 1 trim level: GLS 450 4Matic.
Here's the short version:
The GLS 450 4Matic is the only version described for this model year, so it is the default choice. It gives you the full-size luxury SUV experience with standard AWD, air suspension, a surround-view camera system, and the core MBUX tech suite. The main drawback is that some key features you might expect on a flagship SUV, including leather seating and adaptive cruise control, still cost extra.
Mercedes’ safety package is broad, but advanced driver-assistance features are not standard.
Is now a good time to buy a used 2022 Mercedes-Benz GLS?
This looks like a moderate, selective buyer’s market, so you can shop carefully without expecting every listing to be a bargain.
- Deal availability: 33.7% of listings are priced as good or great deals.
- Inventory: There are 926 listings available.
- Price trend: Prices have softened 13.66% compared with last year.
- Clean inventory: 86.1% of listings are accident-free.
If you find a listing below $48,683.95, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2022 Mercedes-Benz GLS's resale value?
The current average of $48,712 sits slightly below last year's $56,420.
That price movement suggests the market has already adjusted downward, which can help you as a buyer but may pressure future resale if you plan to sell soon. For a future owner, the softer pricing means there is less room for appreciation and more emphasis on buying well. A well-kept example should still hold appeal because it remains a flagship luxury SUV with strong demand characteristics.
Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.
Is the 2022 Mercedes-Benz GLS safe?
It earns a 6/10 safety score from our experts.
Standard safety features include forward collision warning, automatic emergency braking, a driver-attention monitor, automatic high beams, blind-spot monitoring, a surround-view camera system, Crosswind Assist, parking assist, and Pre Safe. The review also notes that Mercedes leaves a lot on the table, since adaptive cruise control, lane-keep assist, and second-row side airbags are not standard.
That means you should pay close attention to how a specific used example is equipped, especially if you want more advanced driver assistance. The lack of standard advanced safety features is the main safety caveat for this model year.
Should I buy a 2022 Mercedes-Benz GLS or consider a different year?
If you're weighing the 2022 against nearby model years, here's how to think about it:
Choose the 2022 if:
- 33.7% of listings are priced as good or great deals.
- Accident-free inventory is solid at 86.1% — always verify the vehicle history report.
- Price trend: Prices have softened 13.66% compared with last year.
- Owners rate it 5/5 — a strong satisfaction signal.
- The 2022 stands out as the only GLS version available at the time of review, with a strong luxury focus and a 7.33/10 expert rating.
Consider the 2021 if:
- At $48,356, the 2021 costs less than the current year's $48,712 average.
- It blends three-row practicality with a premium feel.
The bottom line: If you want the current-year GLS at a softer price than last year and you value the model’s flagship-luxury positioning, the 2022 is the cleaner pick. If your priority is spending less up front, the 2021 is the better value path, especially if you can find one in strong condition.
These recommendations are based on CarGurus' proprietary market data from August 21, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles

The Best Large SUVs for Gas Mileage in 2026
Large SUVs and great gas mileage don't tend to go hand-in-hand. That said, some models are more impressive than others. Here are our favourites, including the BMW X7 and Chevrolet Tahoe.

The Best New Cars for Old Money Style in 2026
Whether you’re looking for something classic and timeless or you just want a nice vehicle that doesn’t project extreme affluence, there are a lot of new vehicles on the market today that feel luxurious, look elegant, yet don’t attract much attention.

2027 Mercedes-Maybach GLS 680 Pricing, Specs, and Release Date
The Mercedes-Benz GLS lineup gets a refresh for 2027 which includes the Mercedes-Maybach version. Its name changes from GLS 600 to GLS 680 in the process, and the update includes design changes, more power, updated connected technology, and updated ADAS.