Used 2022 Mercedes-Benz E-Class for Sale nearSaint Louis, MO

Compare 2022 Mercedes-Benz E-Class Trims

The E-Class offers a blend of luxury and performance, with options ranging from budget-friendly RWD to sporty AWD models.

• Starting at $31,782
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want luxury features without the AWD price premium. It's the most budget-friendly option in the lineup.

• Avg. market price: $31,782 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 557 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the choice for those seeking a balance of luxury and all-weather capability without breaking the bank.

• Avg. market price: $32,330 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 1,060 listings — widest selection in the lineup
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is ideal for buyers wanting more power and luxury features, though availability may limit options.

• Avg. market price: $37,611 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 96 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without the AWD complexity.

• Avg. market price: $39,723 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 57 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for buyers wanting a sporty coupe with all-wheel drive for enhanced performance and handling.

• Avg. market price: $41,437 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 52 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is the choice for those who want a luxurious convertible experience without the added weight of AWD.

• Avg. market price: $52,883 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 70 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Sedan 4MATIC — "Who It's For"

The AMG E 53 Sedan 4MATIC is for performance enthusiasts who want a sporty sedan with luxury features and advanced technology.

• Avg. market price: $44,091 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 35 listings — lower availability; may limit negotiating room
• View AMG E 53 Sedan 4MATIC listings

AMG E 53 Coupe 4MATIC — "Who It's For"

The AMG E 53 Coupe 4MATIC is ideal for buyers seeking a stylish coupe with high performance and luxury features.

• Avg. market price: $49,740 (updated weekly)
• MPG/MPGe: 20 city / 28 hwy
• Inventory: 42 listings — lower availability; may limit negotiating room
• View AMG E 53 Coupe 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 1,060 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $31,782 avg market price — below the lineup median of $40,580 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 350 RWD

The E 350 RWD offers the best fuel economy in the lineup at 23/31 MPG/MPGe.

Browse E 350 RWD listings

These recommendations are based on CarGurus' proprietary market data from November 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz E-Class cost?

Prices have softened 8.63% compared to this time last year, making it a favorable time to shop this model year.

There are 1,216 listings available, which suggests a healthy amount of inventory to compare.

Is the 2022 Mercedes-Benz E-Class a good car?

Yes — the 2022 Mercedes-Benz E-Class earns a 5/5 user rating and an 8.2/10 expert rating. The standout strength is Safety at 10/10.

The E-Class is positioned as a refined luxury choice with a distinctive open-air option, and the 2022 lineup continues to lean on the model’s established strengths after a substantial refresh the year before. It also keeps the focus on turbocharged four-cylinder and six-cylinder power plants, so you’re looking at a car that emphasizes comfort, prestige, and versatility more than dramatic year-over-year change.

37.6% of listings are marked as good or great deals, which gives you some room to shop selectively.

Is the 2022 Mercedes-Benz E-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The 2022 E-Class is described as a highly versatile luxury car with strong everyday usability, and the expert evaluation highlights its polished character and broad appeal. Its performance setup also points to robust response and a well-rounded driving experience, with the turbocharged six-cylinder and mild-hybrid system designed to improve both power output and efficiency.

The first scheduled maintenance visit is on the house, which helps soften early ownership costs. For used buyers, the main long-term risk is that a complex luxury car can become expensive if prior maintenance or repairs were neglected.

What should I look for when buying a used 2022 Mercedes-Benz E-Class?

Accident-free inventory is solid at 84.4% — always verify the vehicle history report.

You should still check the history report carefully, because a clean listing percentage does not replace a proper paper trail. Prioritize a pre-purchase inspection that focuses on electronics, driver-assistance features, and any signs of wear from luxury-option-heavy use. Pay close attention to condition, since this model can vary a lot depending on body style and equipment.

Key things to evaluate:

• Trim level: The lineup spans coupe, convertible, sedan, and station wagon body styles, and the E-Class can be configured from a more restrained luxury setup to a much more expressive AMG-tuned version. The base E350 sedan is the most straightforward entry point, while higher-spec versions add more visual drama and luxury detail.
• Powertrain: The lineup includes a turbocharged four-cylinder in the E350 and a turbo 3.0-liter inline-six with EQ Boost mild-hybrid technology in the E450, while AMG versions use a more powerful version of the six-cylinder. The six-cylinder setup is the one to target if you want stronger acceleration and a more premium driving feel.
• Safety package: Standard equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Driver Assistance Package adds adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus.
• Infotainment: The cabin uses Mercedes-Benz User Experience with two 12.3-inch screens, including a touchscreen and digital instrument cluster. It supports Apple CarPlay, Android Auto, WiFi service, and an augmented reality navigation overlay.
• Fuel efficiency: The six-cylinder setup is designed to improve both power output and efficiency through EQ Boost mild-hybrid technology.

Which 2022 Mercedes-Benz E-Class trim should I buy?

The 2022 Mercedes-Benz E-Class is offered in 4 trim levels: E350, E450, AMG E53, and AMG E53 Cabriolet.

Here's the short version:

• E350: This is the most accessible way into the lineup, and it gives you the core E-Class experience with the turbocharged four-cylinder. It makes the most sense if you want the badge, comfort, and versatility without chasing the pricier performance and luxury extras.
• E450: This is the best-value trim for most shoppers because it adds the turbo 3.0-liter inline-six with EQ Boost mild-hybrid technology and a stronger all-around driving feel. If you want the sweet spot between refinement and performance, this is the one to target.
• AMG E53: Choose this if you want the more powerful AMG-tuned version of the six-cylinder and a more engaging personality. It suits you best if driving enjoyment matters more than keeping costs in check.
• AMG E53 Cabriolet: This is the choice if you specifically want the open-air body style and the most dramatic presentation. It is the most distinctive version, but it also makes the least sense if you are shopping strictly for value.

Most other safety features are bundled into the extra-cost Driver Assistance Package, so check whether a given car has it before you buy.

Is now a good time to buy a used 2022 Mercedes-Benz E-Class?

This looks like a moderate, selective buyer's market, so you can shop carefully without expecting every car to be a bargain.

• Deal availability: 37.6% of listings are priced as good or great deals.
• Inventory: There are 1,216 listings available.
• Price trend: Prices have softened 8.63% compared with last year.
• Clean inventory: 84.4% of listings are accident-free.

If you find a listing below $38,758, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz E-Class's resale value?

The current average of $38,758 sits slightly below last year's $42,418.

That price movement suggests the market has already adjusted downward, which can help you buy more confidently now. For a future seller, it also means you should expect resale value to depend heavily on condition, equipment, and how well the car has been maintained. Well-kept examples with desirable options should hold up better than neglected ones.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz E-Class safe?

The 2022 Mercedes-Benz E-Class earns a 10/10 safety score from our experts.

It comes with standard forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The E-Class Cabriolet also includes pop-up rollbars, and the Driver Assistance Package adds adaptive cruise control, lane-centering assistance, lane-keeping support, blind-spot assist, evasive steering assist, rear collision preparation, and more.

One important caveat is that most of the more advanced driver aids are not standard and are bundled into the extra-cost package, so you should confirm whether a specific used example has it.

Should I buy a 2022 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 37.6% of listings are priced as good or great deals.
• Accident-free inventory is solid at 84.4% — always verify the vehicle history report.
• Price trend: Prices have softened 8.63% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• The year’s biggest change is the cancellation of the AMG E63 and E63 S, leaving a lineup centered on turbocharged four-cylinder and six-cylinder power.

Consider the 2021 if:

• At $35,924, the 2021 costs less than the current year's $38,758 average.
• It offers four body styles, four engines, and a broader model spread.

The bottom line: If you want the newer year with softer pricing, strong safety, and a healthy used-car market, the 2022 is the better default choice. If your priority is spending less up front and you want a broader model range, the 2021 is the more price-sensitive alternative.

How does the 2022 Mercedes-Benz E-Class compare to the 2022 BMW 5 Series?

Read our full side-by-side expert comparison here.

These recommendations are based on CarGurus' proprietary market data from November 10, 2026, CarGurus experts' opinions, and generative AI.