Used 2022 Mercedes-Benz E-Class for Sale nearBuffalo, NY

Compare 2022 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly RWD options to luxurious AWD models, catering to various preferences and needs.

• Starting at $32,289
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the AWD price premium. It's the most budget-friendly option in the lineup.

• Avg. market price: $32,289 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 517 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the pick for shoppers who want all-wheel drive without stepping up to a higher price point. It's also the most popular trim in the lineup.

• Avg. market price: $36,142 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 940 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is the pick for shoppers who want a powerful engine and luxury features without going for the highest price.

• Avg. market price: $42,089 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 90 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is the pick for shoppers who want a stylish coupe with luxury features without the AWD price.

• Avg. market price: $41,059 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 70 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is the pick for shoppers who want a sporty coupe with all-wheel drive and luxury features.

• Avg. market price: $44,118 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 57 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is the pick for shoppers who want a luxurious convertible experience without the AWD price premium.

• Avg. market price: $51,420 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 62 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Sedan 4MATIC — "Who It's For"

The AMG E 53 Sedan 4MATIC is the pick for shoppers who want a performance-oriented luxury sedan with all-wheel drive.

• Avg. market price: $47,118 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 40 listings — lower availability; may limit negotiating room
• View AMG E 53 Sedan 4MATIC listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is the pick for shoppers who want a luxurious convertible with all-wheel drive.

• Avg. market price: $46,969 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 39 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 940 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $32,289 avg market price — below the lineup median of $43,103 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 350 RWD

The E 350 RWD offers the best fuel economy in the lineup with 23/31 MPG/MPGe.

Browse E 350 RWD listings

These recommendations are based on CarGurus' proprietary market data from September 24, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz E-Class cost?

Prices have softened 7.88% compared to this time last year, making it a favorable time to shop this model year.

There are 1,054 listings available, which gives you a decent amount of inventory to compare.

Is the 2022 Mercedes-Benz E-Class a good car?

Yes — it earns 5/5 from users and 8.17/10 from our experts. The standout strength is Safety at 10/10.

The 2022 Mercedes-Benz E-Class is aimed at you if you want a refined luxury car with a distinctive personality, especially because it offers a Cabriolet body style that stands out in the class. It also carries forward the updated look and feel from the prior refresh, while keeping the focus on comfort and style rather than a major redesign.

The market also shows 33.9% of listings priced as good or great deals, which suggests there are worthwhile opportunities if you shop carefully.

Is the 2022 Mercedes-Benz E-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The 2022 Mercedes-Benz E-Class is presented as a polished, comfort-first luxury car with standard convenience features and a cabin that feels upscale. Its turbocharged four-cylinder and six-cylinder powertrains, along with the mild-hybrid setup on higher-output versions, point to a modern mechanical package rather than an outdated one.

The performance notes also emphasize that the drivetrain is designed to deliver strong response across a wide rev range, which is a good sign for everyday drivability. If you want a used luxury car that feels special without being overly complicated in its mission, this model fits that brief well.

For used buyers, the main long-term ownership risk is that a premium, feature-rich convertible can be expensive to keep in top shape.

What should I look for when buying a used 2022 Mercedes-Benz E-Class?

Accident-free inventory is solid at 84.9% — always verify the vehicle history report.

You should still run a history report on any car you’re considering, even if the listing looks clean at first glance. Prioritize a pre-purchase inspection, especially if the car has been optioned heavily or used as a convertible. Focus on overall condition, because luxury features and open-air hardware can be costly if they’ve been neglected.

Key things to evaluate:

• Trim level: The lineup spans coupe, convertible, sedan, and station wagon body styles, and the cabin presentation changes a lot with equipment level. Base versions are more restrained, while higher-spec examples add the richer materials and visual drama that make the car feel special.
• Powertrain: You’ll find turbocharged four-cylinder and turbocharged 3.0-liter inline-six powertrains, with EQ Boost mild-hybrid technology on the six-cylinder setup. The stronger version is tuned for robust response and quick acceleration.
• Safety package: Standard equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, and rear cross-traffic alert. The Driver Assistance Package adds adaptive cruise control, lane-centering assistance, lane-keeping support, blind-spot assist, evasive steering assist, and rear-collision preparation.
• Infotainment: The cabin uses two 12.3-inch screens, and the system supports Apple CarPlay and Android Auto. It also offers WiFi service and an augmented-reality navigation overlay.
• Fuel efficiency: No fuel-economy figure is stated in the available data.

Which 2022 Mercedes-Benz E-Class trim should I buy?

The 2022 Mercedes-Benz E-Class is offered in 3 trim levels: E350, E450, AMG E53.

Here's the short version:

• E350: This is the entry point if you want the E-Class experience with the turbocharged four-cylinder setup. It makes the most sense if you care more about the car’s luxury feel and body-style variety than maximum performance.
• E450: This is the best-value trim for most shoppers because it adds the turbocharged inline-six with EQ Boost mild-hybrid technology while still keeping the E-Class’s comfort-first character. If you want stronger acceleration without jumping to AMG pricing, this is the one to target.
• AMG E53: Choose this if you want the most performance-oriented version in the lineup, with the AMG-tuned 3.0-liter turbo-six, AMG Speedshift transmission, AMG Performance 4Matic+ AWD, and AMG-tuned suspension. It suits you best if driving excitement matters more than value.

The safety package is mostly standard, but the Driver Assistance Package remains an extra-cost upgrade.

Is now a good time to buy a used 2022 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so you can shop with some leverage if you’re patient.

• Deal availability: 33.9% of listings are priced as good or great deals.
• Inventory: There are 1,054 listings available.
• Price trend: Prices have softened 7.88% compared with last year.
• Clean inventory: 84.9% of listings are accident-free.

If you find a listing below $39,523, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz E-Class's resale value?

The current average of $39,523 sits slightly below last year's $42,904.

That price movement suggests the market has cooled, which can help you buy at a better entry point today. For a future seller, it also means you should expect resale value to depend heavily on condition, mileage, and equipment. Well-kept examples with desirable features should hold up better than neglected ones.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz E-Class safe?

The 2022 Mercedes-Benz E-Class earns Top Safety Pick+ recognition from IIHS and five-star ratings from NHTSA.

It earns a 10/10 safety score from our experts.

The E-Class comes with standard forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, and pop-up rollbars on the Cabriolet. Mercedes Pre Safe and Pre Safe Sound are also standard, and the car adds Active Parking Assist plus a surround-view camera system on the AMG E53.

Most of the more advanced driver aids are bundled into the Driver Assistance Package, including adaptive cruise control, lane-centering assistance, lane-keeping assist, blind-spot assist, evasive steering assist, and rear-collision preparation. That means you should check carefully whether a used example has the package if you want the fullest safety tech set.

Should I buy a 2022 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 33.9% of listings are priced as good or great deals.
• Accident-free inventory is solid at 84.9% — always verify the vehicle history report.
• Price trend: Prices have softened 7.88% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• It keeps the refreshed look and standard convenience upgrades while dropping the AMG E63 and E63 S variants.

Consider the 2021 if:

• At $36,344, the 2021 costs less than the current year's $39,523 average.
• It offers broad body-style and powertrain variety with a mid-cycle update.

The bottom line: If you want the newer market position, the 2022 is the better pick because it combines a softer price trend with strong satisfaction and a distinctive body-style lineup. If your priority is spending less up front, the 2021 is the smarter value play, especially if you’re comfortable giving up some of the 2022’s updated standard equipment and market freshness.

These recommendations are based on CarGurus' proprietary market data from September 22, 2026, CarGurus experts' opinions, and generative AI.