Used 2022 Mercedes-Benz E-Class for Sale near Boston, MA
153 results
CarGurus Analysis:
2022 Mercedes-Benz E-Class
With 157 currently listed for sale near Boston, MA and an average price of $44,191.00, 42.0% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
95.5% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class features turbocharged four-cylinder and six-cylinder engines, automatic high-beam headlights as standard, and several body styles including coupe, convertible, and sedan.
CarGurus Analysis: 2022 Mercedes-Benz E-Class
overall

Summary
With 157 currently listed for sale near Boston, MA and an average price of $44,191.00, 42.0% of 2022 Mercedes-Benz E-Class models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Mercedes-Benz E-Class 5 / 5 stars.
95.5% of 2022 E-Class models on CarGurus are accident free.
The 2022 Mercedes-Benz E-Class features turbocharged four-cylinder and six-cylinder engines, automatic high-beam headlights as standard, and several body styles including coupe, convertible, and sedan.
Why it stands out
The 2022 Mercedes-Benz E-Class continues to dominate its segment with a class-leading blend of luxury, performance, and cutting-edge technology. Notable for offering an impressive variety of body styles, including coupe, convertible, and sedan, it adapts to a wide range of preferences and uses. In addition to its striking design, the 2022 model emphasizes modern tech features such as the advanced MBUX infotainment system, which incorporates dual 12.3-inch displays for seamless interaction. Performance-wise, buyers can appreciate the smooth power delivery from the turbocharged engines, particularly the AMG E53 which offers exhilarating acceleration paired with a refined driving experience. The vehicle is built for comfort, with features like heated seats, an Aircap system for reduced turbulence, and high-quality interior finishes. Although the cost may be high, the E-Class delivers exceptional value through its luxurious amenities and performance capabilities.
Other model years to consider
- Average price: $30,549.00
- Good/great deal percentage: 34.0%
- User rating: 5 / 5
- Total listings: 188
- Average price: $28,118.00
- Good/great deal percentage: 29.8%
- User rating: 4.76 / 5
- Total listings: 275
- Average price: $18,231.00
- Good/great deal percentage: 28.9%
- User rating: 4.78 / 5
- Total listings: 256
This analysis is based on CarGurus' proprietary market data from April 21, 2026, CarGurus experts' opinions, and generative AI.
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5.0 Overall rating
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Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 6, 2025
The E-class is the midsize line of Mercedes cars, so it’s fine for all sizes except for very tall and large people. The new inline six cylinder is my favorite engine because it has plenty of power and is fuel efficient. Overall, the quality is here and has been for years.
Anonymous
Reviewed a 2022 Mercedes-Benz E-Class on Jul 12, 2024
Great value. 39K with 14K miles and in great condition with premium package. Took it to the Mercedes dealer for inspection and they said it was in great shape (tires, brakes, belts, filters, oil, fluid level, electronics, and even spark plugs). The interior was in pristine condition and the exterior is just as perfect.
Jim S
Reviewed a 2022 Mercedes-Benz E-Class on Mar 7, 2025
The E-class Mercedes Is the midsize car segment, and is large enough for many people who are not over 6’ 6” or more than 380 pounds in my estimation. Quality is noticed in interior seating and fit and finish. The relatively new Inline six cylinder engine has enough power with above average fuel economy. Other engines are available in four cylinder and eight cylinder variants.
Bill F
Reviewed a 2022 Mercedes-Benz E-Class on Jan 7, 2023
First class, quality material and build! You know maintenance is expensive going into it, but it is what it is.
2022 Mercedes-Benz E-Class Trims
| Trim type | MSRP |
|---|---|
| E 450 Cabriolet RWD | $73,250 |
| AMG E 53 Coupe 4MATIC | $77,600 |
| E 450 4MATIC Coupe AWD | $68,600 |
| E 450 Coupe RWD | $66,100 |
| AMG E 53 Sedan 4MATIC | $75,000 |
| E 450 4MATIC Sedan AWD | $62,750 |
| E 350 4MATIC | $57,450 |
| E 350 RWD | $54,950 |
2022 Mercedes-Benz E-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Mercedes-Benz E-Class prices has changed over time.
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