Used 2022 Lexus IS for Sale nearSaint Louis, MO
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 36,200
- Stock #:
- A17812M
- VIN:
- JTHAA1D27N5119756
Sponsored by Clement Supercenter
2022 Lexus IS
300 RWD
36,200 mi
$34,221
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- Automatic
- Mileage:
- 16,439
- Stock #:
- P19238
- VIN:
- JTHGZ1B21M5039549
Sponsored Listing
2021 Lexus IS
350 F Sport RWD
16,439 mi
$42,609
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- White
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Dual Clutch
- Mileage:
- 99,914
- Stock #:
- #486
- VIN:
- JTHAA1D20M5114560
2021 Lexus IS
300 RWD
99,914 mi
$24,019
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 51,771
- Stock #:
- 28600730
- VIN:
- JTHDA1D20P5125043
2023 Lexus IS
300 RWD
51,771 mi
$33,347
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- Automatic
- Mileage:
- 51,429
- Stock #:
- 28732072
- VIN:
- JTHGZ1B25M5038453
2021 Lexus IS
350 F Sport RWD
51,429 mi
$39,497
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 67,636
- Stock #:
- 26179
- VIN:
- JTHGZ1B24P5063834
2023 Lexus IS
350 F SPORT RWD
67,636 mi
$36,086
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,338
- Stock #:
- C7382
- VIN:
- JTHGZ1B22N5054272
2022 Lexus IS
350 F Sport RWD
56,338 mi
$38,858
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Iridium
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel Leather
- Transmission:
- Automatic
- Mileage:
- 50,127
- Stock #:
- T21461B
- VIN:
- JTHAA1D22M5113832
2021 Lexus IS
300 RWD
50,127 mi
$30,289
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Exterior color:
- Atomic Silver
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 14,845
- Stock #:
- WP9990A
- VIN:
- JTHGZ1E20N5026630
2022 Lexus IS
350 F SPORT 2 AWD
14,845 mi
$45,500
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- Automatic
- Mileage:
- 16,439
- Stock #:
- P19238
- VIN:
- JTHGZ1B21M5039549
2021 Lexus IS
350 F Sport RWD
16,439 mi
$42,609
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Ultra White
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- White W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 96,138
- Stock #:
- F041084
- VIN:
- JTHGZ1B24M5041084
2021 Lexus IS
350 F Sport RWD
96,138 mi
$33,156
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 52,054
- Stock #:
- 13999B
- VIN:
- JTHGZ1B26M5048425
2021 Lexus IS
350 F Sport RWD
52,054 mi
$38,223
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black W/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 48,398
- Stock #:
- TI043249
- VIN:
- JTHGZ1B29M5043249
-$936
2021 Lexus IS
350 F Sport RWD
48,398 mi
$37,475
$36,539
CarGurus Analysis:
2022 Lexus IS
With 89 currently listed for sale near Saint Louis, MO and an average price of $44,935.00, 46.1% of 2022 Lexus IS models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus IS 5 / 5 stars.
100.0% of 2022 Lexus IS models on CarGurus are accident free.
The 2022 Lexus IS features a powerful V6 engine, luxurious interior, and advanced safety technologies, making it a compelling choice for buyers seeking a sporty yet comfortable sedan.
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- Silver
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Rioja Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 38,558
- Stock #:
- 128468
- VIN:
- JTHDA1D23P5128468
2023 Lexus IS
300 RWD
38,558 mi
$35,906
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- White Pearl
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 19,820
- Stock #:
- 3024735
- VIN:
- JTHDA1D24P5127541
2023 Lexus IS
300 RWD
19,820 mi
$38,965
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Exterior color:
- Cloudburst Gray
- Interior color:
- Circuit Red
- Transmission:
- 6-Speed Automatic
- Mileage:
- 42,697
- Stock #:
- 028585CP
- VIN:
- JTHGZ1E25P5028585
2023 Lexus IS
350 F SPORT 3 AWD
42,697 mi
$42,603
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Iridium
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 40,148
- Stock #:
- 7326
- VIN:
- JTHGZ1B29P5060721
2023 Lexus IS
350 F SPORT RWD
40,148 mi
$42,922
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 260 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 6-Speed Automatic
- Mileage:
- 48,123
- Stock #:
- PE048604
- VIN:
- JTHD81F24N5048604
2022 Lexus IS
300 AWD
48,123 mi
$35,103
- Year:
- 2021
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 260 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown
- Transmission:
- Automatic
- Mileage:
- 40,412
- Stock #:
- 43735
- VIN:
- JTHC81F22M5043735
2021 Lexus IS
300 AWD
40,412 mi
$34,247
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 27,500
- Stock #:
- 27009AT
- VIN:
- JTHGZ1B26P5062152
2023 Lexus IS
350 F SPORT RWD
27,500 mi
$46,079
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 61,378
- Stock #:
- 068629
- VIN:
- JTHBZ1B23P5068629
2023 Lexus IS
350 F SPORT RWD
61,378 mi
$38,222
- Year:
- 2022
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 241 hp 2L I4
- Exterior color:
- White
- Combined gas mileage:
- 26 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 44,421
- Stock #:
- W119294
- VIN:
- JTHDA1D2XN5119294
2022 Lexus IS
300 RWD
44,421 mi
$32,314
- Year:
- 2023
- Make:
- Lexus
- Model:
- IS
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 311 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 24 MPG
- Fuel type:
- Gasoline
- Interior color:
- Circuit Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 43,480
- Stock #:
- 069794
- VIN:
- JTHGZ1B24P5069794
2023 Lexus IS
350 F SPORT RWD
43,480 mi
$41,296
CarGurus Analysis: 2022 Lexus IS
overall
Summary
With 89 currently listed for sale near Saint Louis, MO and an average price of $44,935.00, 46.1% of 2022 Lexus IS models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2022 Lexus IS 5 / 5 stars.
100.0% of 2022 Lexus IS models on CarGurus are accident free.
The 2022 Lexus IS features a powerful V6 engine, luxurious interior, and advanced safety technologies, making it a compelling choice for buyers seeking a sporty yet comfortable sedan.
Why it stands out
The 2022 Lexus IS distinguishes itself with a blend of luxury, performance, and advanced technology. This model offers a powerful V6 engine that delivers an exhilarating driving experience, complemented by a refined interior that prioritizes comfort and quality. The introduction of the IS 500 F Sport Performance variant adds a thrilling V8 option, appealing to driving enthusiasts who crave more power. Additionally, the IS is equipped with the latest safety features, ensuring peace of mind for drivers and passengers alike. While it excels in many areas, some may find the cargo space limited and the road noise more pronounced than expected. Overall, the 2022 Lexus IS is a well-rounded sedan that caters to those who appreciate a luxurious ride without compromising on performance.
Other model years to consider
- Average price: $44,909.00
- Good/great deal percentage: 56.7%
- Total listings: 97
- Average price: $15,550.00
- Good/great deal percentage: 32.5%
- User rating: 4.6 / 5
- Total listings: 77
- Average price: $21,115.00
- Good/great deal percentage: 28.1%
- User rating: 4.78 / 5
- Total listings: 64
This analysis is based on CarGurus' proprietary market data from August 4, 2026, CarGurus experts' opinions, and generative AI.
5.0 Overall rating
Filter by rating
Jessica C
Reviewed a 2022 Lexus IS on Mar 6, 2025
Absolutely love this car. Quiet, luxurious and classy. Has enough power. Only downfall is gas mileage.
Luis D
Reviewed a 2022 Lexus 350 F Sport RWD on Sep 22, 2025
The car is amazing would highly recommend. This car drives like a dream.
John S
Reviewed a 2022 Lexus IS on Sep 27, 2023
Wonderful vehicle very reliable. Basically its a bullet proof engine as long as you maintain the maintenance. Its stylish and resale value is strong.
Anonymous
Reviewed a 2022 Lexus IS on Nov 10, 2023
Can’t get over the quietness of the car city/highway driving. Purchased the Lexus brand for quality and reliability after problems with my previous car. So let’s hope I experience a positive experience from now on
2022 Lexus IS Trims
| Trim type | MSRP |
|---|---|
| 500 F Sport Performance Premium RWD | $61,350 |
| 500 F Sport Launch Edition RWD | $67,400 |
| 350 F SPORT AWD | $45,550 |
| 300 AWD | $41,125 |
| 350 F SPORT 2 AWD | -- |
| 300 RWD | $39,125 |
| 350 F Sport RWD | $43,550 |
2022 Lexus IS Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2022 Lexus IS prices has changed over time.
See more price trends2022 Lexus IS Pricing Analysis: Saint Louis, MO Market Report
Pricing Analysis by Model Year
Key Insights
- Strong Demand for Newer Models: The 2025 Lexus IS is priced at $46,299, which is 14.1% above MSRP, indicating robust demand for the latest model.
- Significant Depreciation for Older Models: The 2017 Lexus IS shows a steep decline, priced at $16,948, reflecting a 55.2% drop from its original MSRP.
- Best Value in Recent Years: The 2021 Lexus IS is priced at $35,890, only 8.3% below MSRP, making it a competitive option for buyers seeking a balance of price and features.
Model Year Pricing
| Model Year | Original MSRP | Avg Price | Price vs MSRP |
|---|---|---|---|
| 2025 Lexus IS | $40,535 | $46,299 | +14.1% |
| 2024 Lexus IS | $40,085 | $44,567 | +11.1% |
| 2021 Lexus IS | $39,050 | $35,890 | -8.3% |
| 2020 Lexus IS | $38,560 | $23,461 | -39.1% |
| 2019 Lexus IS | $38,560 | $25,978 | -32.5% |
| 2017 Lexus IS | $37,825 | $16,948 | -55.2% |
| 2015 Lexus IS | $36,550 | $15,550 | -57.5% |
| 2014 Lexus IS | $36,100 | $21,115 | -41.5% |
These recommendations are based on CarGurus' proprietary market data from August 6, 2026, CarGurus experts' opinions, and generative AI.
FAQs
How much does the 2022 Lexus IS cost in Saint Louis, MO?
Is the 2022 Lexus IS a good car?
How many 2022 Lexus IS vehicles in Saint Louis, MO have no reported accidents or damage?
Is the 2022 Lexus IS safe?
What is the fuel economy of the 2022 Lexus IS?
What fuel types are available?
Relevant articles
The Most Reliable Luxury Cars of 2026
Luxury cars give you the best of most things but which are the most reliable luxury cars you can buy? Our guide has all the details.
Best Lexus Deals in July 2026
Leasing a Lexus can be a great way to get into a new car from one of the most popular luxury brands at a more affordable monthly rate. Here are the best deals we've found this month on Lexus vehicles.
2026 Lexus IS Pricing, Specs, and Release Date
The Lexus IS gets a refresh for 2026 with new styling touches, a bigger infotainment display and instrument cluster, and retuned driving dynamics.
