Used 2021 Mercedes-Benz S-Class for Sale nearBirmingham, AL
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,736
- Stock #:
- T0162
- VIN:
- W1K6G7GB5NA142292
Sponsored by Cadillac of Birmingham
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
42,736 mi
$68,759
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 96,096
- Stock #:
- 035527
- VIN:
- W1K6G7GBXMA035527
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
96,096 mi
$45,269
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 87,175
- Stock #:
- 099396
- VIN:
- W1K6G7GB9NA099396
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
87,175 mi
$48,589
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Macchiato/Magma Gray
- Transmission:
- 9-Speed Automatic
- Mileage:
- 32,587
- Stock #:
- 067274
- VIN:
- W1K6G6DB2NA067274
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
32,587 mi
$55,599
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Buckskin Nappa
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,599
- Stock #:
- EP0213
- VIN:
- WDDUG8GB5LA501375
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
49,599 mi
$42,620
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Magnetite Black Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,628
- Stock #:
- 11108
- VIN:
- WDDUG6EBXLA514744
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
44,628 mi
$37,004
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- Automatic
- Mileage:
- 47,673
- Stock #:
- NA110345
- VIN:
- W1K6G7GB5NA110345
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
47,673 mi
$64,804
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 23,250
- Stock #:
- JB157483P
- VIN:
- W1K6G6DB1NA157483
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
23,250 mi
$59,826
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 39,377
- Stock #:
- 073511
- VIN:
- W1K6G7GB7NA073511
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
39,377 mi
$68,571
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- Rear-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 50,618
- Stock #:
- 513856
- VIN:
- WDDUG8DB9LA513856
-$1,510
2020 Mercedes-Benz S-Class
S 560 Sedan RWD
50,618 mi
$41,132
$39,622
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 82,300
- Stock #:
- 047837C01
- VIN:
- W1K6G7GB8MA047837
-$1,000
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
82,300 mi
$49,070
$48,070
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 603 hp 4L V8
- Exterior color:
- [040] Black
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Porcelain/Black
- Transmission:
- Automatic
- Mileage:
- 59,782
- Stock #:
- 426042
- VIN:
- WDDUG8JB7LA522009
![[040] Black 2020 Mercedes-Benz S-Class Sedan All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/06/01/22/54/2020_mercedes-benz_s-class-pic-3335666247717155142-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2020 Mercedes-Benz S-Class
S AMG 63 4MATIC Sedan AWD
59,782 mi
$67,492
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 63,212
- Stock #:
- 26308
- VIN:
- W1K6G6DB7NA105484
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
63,212 mi
$49,242
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 695 currently listed for sale and an average price of $61,750.00, 31.8% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and powerful engine options, including a 4.0-liter twin-turbo V8 in the S580 variant.
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,552
- Stock #:
- 7271
- VIN:
- W1K6G7GB5NA146617
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,552 mi
$68,724
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diam
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 25,965
- Stock #:
- 152088MM
- VIN:
- W1K6G7GB1NA152088
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,965 mi
$71,355
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 9-Speed Automatic
- Mileage:
- 51,230
- Stock #:
- 7039
- VIN:
- W1K6G7GB8NA106497
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
51,230 mi
$65,724
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Obsidian Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 18,278
- Stock #:
- 2315
- VIN:
- W1K6G7GB1NA097318
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
18,278 mi
$71,817
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 3L V6
- Exterior color:
- Lunar Blue Metallic
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silk Beige/Espresso Brown
- Transmission:
- Automatic
- Mileage:
- 47,611
- Stock #:
- P6583
- VIN:
- WDDUG6EB5LA511167
2020 Mercedes-Benz S-Class
S 450 4MATIC Sedan AWD
47,611 mi
$34,749
- Year:
- 2020
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 463 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Nut Brown/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 72,285
- Stock #:
- 147811BU
- VIN:
- W1KUG8GB7LA556037
2020 Mercedes-Benz S-Class
S 560 4MATIC Sedan AWD
72,285 mi
$38,982
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 429 hp 3L I6
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 54,876
- Stock #:
- 26305
- VIN:
- W1K6G6DB8NA166553
2022 Mercedes-Benz S-Class
S 500 4MATIC AWD
54,876 mi
$50,710
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey Metallic)
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 42,736
- Stock #:
- T0162
- VIN:
- W1K6G7GB5NA142292
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
42,736 mi
$68,759
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Gray (Graphite Grey)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 39,376
- Stock #:
- P6682
- VIN:
- W1K6G7GB1MA036369
2021 Mercedes-Benz S-Class
S 580 Sedan 4MATIC
39,376 mi
$61,749
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 16,599
- Stock #:
- M1863
- VIN:
- W1K6G7GB2NA097361
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
16,599 mi
$71,854
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 695 currently listed for sale and an average price of $61,750.00, 31.8% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 4 / 5 stars.
84.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, advanced safety features, and powerful engine options, including a 4.0-liter twin-turbo V8 in the S580 variant.
Why it stands out
The 2021 Mercedes-Benz S-Class continues to uphold its reputation as a flagship luxury sedan, offering a blend of performance, comfort, and cutting-edge technology. With a choice between the S500 and S580 models, buyers can enjoy powerful engine options, including a 3.0-liter turbocharged inline-six and a 4.0-liter twin-turbo V8, delivering impressive horsepower and torque. The S-Class is equipped with a state-of-the-art infotainment system featuring a 12.8-inch OLED touchscreen and a 12.3-inch digital instrument cluster, enhancing the driving experience with intuitive controls and connectivity options. Additionally, the vehicle boasts a luxurious interior with high-quality materials and advanced safety features, including adaptive cruise control and a rear-passenger airbag. While the S-Class is not the most budget-friendly option in its class, its combination of luxury, performance, and technology makes it a compelling choice for discerning buyers.
Other model years to consider
- Average price: $79,140.00
- Good/great deal percentage: 31.2%
- User rating: Not available
- Total listings: 1,213
- Average price: $63,886.00
- Good/great deal percentage: 31.6%
- User rating: 4.5 / 5
- Total listings: 1,102
- Average price: $25,706.00
- Good/great deal percentage: 31.6%
- User rating: 4.95 / 5
- Total listings: 936
This analysis is based on CarGurus' proprietary market data from July 20, 2026, CarGurus experts' opinions, and generative AI.
4.0 Overall rating
Filter by rating
Randall H
Reviewed a 2021 Mercedes-Benz S-Class on Aug 28, 2025
The car was a lemon. Bought back by mb. And was in an accident. They didn’t divulge this info. Ar has had many tire issues as well. Don’t buy it Way overpriced.
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
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