Used 2021 Mercedes-Benz E-Class for Sale nearJacksonville, FL

Compare 2021 Mercedes-Benz E-Class Trims

The E-Class offers a range of trims from budget-friendly options to luxurious performance models, catering to various preferences and needs.

• Starting at $28,807
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

Missing data displayed as "—".

Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the higher price tag of AWD options.

• Avg. market price: $28,807 (updated weekly)
• MPG/MPGe: 22 city / 31 hwy
• Inventory: 529 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the choice for those seeking all-wheel drive without a significant price increase, making it a popular option.

• Avg. market price: $29,500 (updated weekly)
• MPG/MPGe: 22 city / 30 hwy
• Inventory: 922 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is ideal for buyers wanting a powerful engine and luxury features, though availability is limited.

• Avg. market price: $36,061 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 99 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is perfect for those who desire a stylish coupe with luxury features without the AWD premium.

• Avg. market price: $34,482 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 59 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is for buyers seeking a sporty coupe with all-wheel drive and premium features.

• Avg. market price: $42,229 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 54 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is ideal for those wanting a luxurious convertible experience without the AWD cost.

• Avg. market price: $44,138 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 60 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is for shoppers who want a luxurious convertible with all-wheel drive capabilities.

• Avg. market price: $39,416 (updated weekly)
• MPG/MPGe: 23 city / 29 hwy
• Inventory: 37 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

AMG E 63 S Sedan 4MATIC — "Who It's For"

The AMG E 63 S Sedan 4MATIC is the choice for performance enthusiasts seeking a high-powered luxury sedan.

• Avg. market price: $81,338 (updated weekly)
• MPG/MPGe: 16 city / 23 hwy
• Inventory: 71 listings — lower availability; may limit negotiating room
• View AMG E 63 S Sedan 4MATIC listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 922 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 350 RWD

At $28,807 avg market price — below the lineup median of $37,738 — it's the most accessible entry point.

Browse E 350 RWD listings

Best for Fuel Economy — E 450 Coupe RWD

The E 450 Coupe RWD offers the best fuel economy in the lineup with 23 MPG city and 31 MPG highway.

Browse E 450 Coupe RWD listings

These recommendations are based on CarGurus' proprietary market data from September 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2021 Mercedes-Benz E-Class cost?

Prices have softened 15.10% compared to this time last year, making it a favorable time to shop this model year.

There are 781 listings available, which gives you a meaningful amount of inventory to compare.

Is the 2021 Mercedes-Benz E-Class a good car?

Yes — the 2021 Mercedes-Benz E-Class earns a 4.7/5 user rating and an 8.33/10 expert rating. The model scores 10/10 across Technology and Safety.

Owners consistently praise the blend of luxury, performance, and beautiful design, along with the comfortable interior and advanced features. The E-Class also stands out for its multiple powertrain options and impressive technology, which makes it appealing whether you want something more relaxed or more powerful.

The trade-offs are that it can feel overpriced to some buyers, and advanced safety features are not standard.

With its broad body-style and engine lineup, it works well if you want a premium car that can be tailored to different priorities. Good and great deals account for 34.4% of listings, which suggests there are still worthwhile opportunities if you shop carefully.

Is the 2021 Mercedes-Benz E-Class reliable?

Owners rate it 4.7/5, a strong signal of long-term satisfaction.

The owner feedback also points to a car that feels dependable, with praise centered on its comfortable interior, luxury feel, and overall confidence in daily use. The expert notes reinforce that impression by describing the E-Class as a do-it-all machine with a quiet, excellent powertrain choice and strong comfort in normal driving.

The 48-volt setup is designed to support smoother starts, more frequent engine shutoff, and lower emissions, which can help the car feel modern and efficient in use. For used buyers, the main long-term ownership risk is that this is a complex luxury car, so condition and maintenance history matter a lot.

What should I look for when buying a used 2021 Mercedes-Benz E-Class?

Accident-free inventory is solid at 76.4% — always verify the vehicle history report.

You should still run a history report on any car you’re considering, even if it looks clean on the listing page. Prioritize a pre-purchase inspection, especially on higher-mileage examples or cars with lots of options. Focus on condition, because this model’s appeal depends heavily on how well the interior, electronics, and luxury features have been maintained.

Key things to evaluate:

• Trim level: The cabin is richly appointed even in lower trims, but the base setup lacks some of the more indulgent touches you’ll find higher up the range. If you want the most complete luxury experience, look closely at how much equipment the car has beyond the entry-level presentation.
• Powertrain: You’ll find a revised 2.0-liter turbo four-cylinder, electrified inline-six powertrains, and an AMG V8 in the high-performance model. The four-cylinder is described as underwhelming, while the inline-six is quiet and excellent for a car this size.
• Safety package: Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assist features are optional, so check carefully for the specific equipment you want.
• Infotainment: The car uses MBUX with two 12-inch screens, touch and swipe controls, natural voice processing, and online search. Apple CarPlay and Android Auto are standard, but they are not wireless, and the system does not update over the air.
• Fuel efficiency: The E450 sedan returns 26 mpg combined (23 mpg city, 30 mpg highway), the E350 4Matic sedan returns 25 mpg combined (22 mpg city, 30 mpg highway), the AMG E53 sedan returns 25 mpg combined (22 mpg city, 29 mpg highway), and the AMG E63 sedan returns 18 mpg combined (16 mpg city, 23 mpg highway).

Which 2021 Mercedes-Benz E-Class trim should I buy?

The 2021 Mercedes-Benz E-Class is offered in 13 trim levels: E350, E350 4Matic, E450 4Matic, AMG E53, AMG E63 S, sedan, wagon, coupe, convertible, Luxury package, Sport package, AMG models, and E63 S.

Here's the short version:

• E350: This is the entry point, and it gives you the E-Class experience at the lowest price, but the base four-cylinder is the least convincing powertrain in the lineup.
• E350 4Matic: This is the better all-weather choice if you want the base engine with added traction, though it still won’t feel as strong as the six-cylinder models.
• E450 4Matic: This is the best-value pick for most shoppers because it brings the quiet, excellent electrified inline-six and a more satisfying overall balance of performance and refinement.
• AMG E53: Choose this if you want the sharper performance edge, brisk acceleration, and the more dramatic AMG character without jumping all the way to the V8 model.
• AMG E63 S: This is the one for maximum performance, with a hand-built V8, serious power, and a much more extreme personality than the rest of the range.

The safety package is not fully standard, so make sure the specific car you’re considering has the driver-assist features you want.

Is now a good time to buy a used 2021 Mercedes-Benz E-Class?

This is a moderate market for selective buyers, so you can shop with some leverage if you’re patient.

• Deal availability: 34.4% of listings are priced as good or great deals.
• Inventory: There are 781 listings available.
• Price trend: Prices have softened 15.10% compared with last year.
• Clean inventory: 76.4% of listings are accident-free.

If you find a listing below $35,895, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2021 Mercedes-Benz E-Class's resale value?

The current average of $36,020 sits slightly below last year's $42,427.

That drop suggests the market has already adjusted downward, which can help you buy at a more favorable entry point today. For a future seller, the key implication is that resale will depend heavily on how well the car is equipped and maintained, since buyers in this segment respond strongly to condition and feature content.

Because the model still has broad appeal and strong owner satisfaction, it should remain attractive to used shoppers who want a luxury car with real versatility. Vehicles with strong owner satisfaction ratings, like this model year's 4.7/5, tend to retain buyer demand, which supports resale value over time.

Is the 2021 Mercedes-Benz E-Class safe?

The 2021 Mercedes-Benz E-Class sedan and wagon scored a five-star overall rating from NHTSA, with five-star ratings in frontal, side, and rollover tests, though the driver's side received a four-star frontal crash rating.

It earns a 10/10 safety score from our experts.

Forward automatic emergency braking, a driver-attention monitor, and blind-spot monitoring are standard. Other driver-assist features are optional, so you’ll want to confirm the exact equipment on any used example you’re considering.

The safety picture is strong overall, but the fact that advanced safety features are not standard means trim and option content matter more than they do on some rivals.

Should I buy a 2021 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2021 against nearby model years, here's how to think about it:

Choose the 2021 if:

• 34.4% of listings are priced as good or great deals.
• Accident-free inventory is solid at 76.4% — always verify the vehicle history report.
• Price trend: Prices have softened 15.10% compared with last year.
• Owners rate it 4.7/5 — a strong satisfaction signal.
• It brings a mid-cycle update to the infotainment system, engines, and exterior styling.

Consider the 2020 if:

• At $30,429, the 2020 costs less than the current year's $36,020 average.
• It offers a broad premium feel with a new base engine and strong design.

Consider the 2022 if:

• At $39,758, the 2022 costs more than the current year's $36,020 average.
• It carries forward the refresh and adds standard convenience features like automatic high beams.

The bottom line: If you want the most current version of this generation with strong tech and broad appeal, the 2021 is the best all-around choice. If price matters most, the 2020 is the value play, while the 2022 makes sense if you want a slightly newer car and don’t mind paying more.

These recommendations are based on CarGurus' proprietary market data from September 15, 2026, CarGurus experts' opinions, and generative AI.