The 2004 Lexus RX 330 was the long-awaited redesign of the company's top-selling "crossover" vehicle, the RX 300. Like the 300, the 330 was built up from the Toyota Camry platform. For 2004, 5.9 inches were added to the overall length, and 4 inches were added to the wheelbase. Drivers of the previous model had repeatedly commented on the need for more space.

The RX now had a more powerful engine: a 3.3-liter V6 that made 230 hp, up 10 horses from the previous 3.0-liter V6. The transmission was still offered only as an automatic, but it was upgraded from a four-speed to a five. Gas mileage improved slightly. The FWD model was good for 20/26 mpg.

Owners of the RX 300 who upgraded were pleased to find many of their key concerns addressed with the restyled 330: turning radius was improved, the console was less invasive, and it had more horsepower, more room, and a sleeker look. Others felt the 330 inherited some of its predecessor's shortcomings, like poor driver and rear visibility and blind spots when changing lanes.