Used 2021 RAM 2500 for Sale near Missouri
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 61,479
- Stock #:
- 9907A
- VIN:
- 3C6UR5FJ7NG351423


Sponsored by Mainstreet CDJR of Lansing
2022 RAM 2500
Laramie Crew Cab 4WD
61,479 mi
$42,950
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Diamond Black Crystal Pearlcoat
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 35,825
- Stock #:
- C601
- VIN:
- 3C6UR5SL6MG641058

Sponsored Listing
2021 RAM 2500
Limited Crew Cab 4WD
35,825 mi
$59,206
- Year:
- 2020
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Gray (Granite Crystal Metallic Clearcoat)
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 83,675
- Stock #:
- 19843
- VIN:
- 3C6UR5SL8LG214401

-$2,250
Sponsored Listing
2020 RAM 2500
Limited Crew Cab 4WD
83,675 mi
$50,599
$48,349
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Gasoline
- Interior color:
- Diesel Gray/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 108,975
- Stock #:
- NG237743
- VIN:
- 3C6UR5DJXNG237743

2022 RAM 2500
Big Horn Crew Cab 4WD
108,975 mi
$32,431
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Blue
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 42,054
- Stock #:
- 6670
- VIN:
- 3C6UR5FJ9NG230277

2022 RAM 2500
Laramie Crew Cab 4WD
42,054 mi
$46,988
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 61,479
- Stock #:
- 9907A
- VIN:
- 3C6UR5FJ7NG351423

2022 RAM 2500
Laramie Crew Cab 4WD
61,479 mi
$42,950
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Pearl White
- Fuel type:
- Gasoline
- Interior color:
- Light Mountain Brown/Mountain Brown
- Transmission:
- 8-Speed Automatic
- Mileage:
- 51,069
- Stock #:
- 217669C
- VIN:
- 3C6UR5GJ7NG217669

2022 RAM 2500
Limited Longhorn Crew Cab 4WD
51,069 mi
$49,388
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Silver
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,523
- Stock #:
- 682021
- VIN:
- 3C6UR5CJ5MG682021

2021 RAM 2500
Tradesman Crew Cab 4WD
70,523 mi
$33,645
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Diamond Black Crystal Pearlcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 96,587
- Stock #:
- C26265A
- VIN:
- 3C6UR5FJ1MG654292

2021 RAM 2500
Laramie Crew Cab 4WD
96,587 mi
$36,294
- Year:
- 2020
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Pearl White
- Fuel type:
- Diesel
- Interior color:
- LIGHT FROST
- Mileage:
- 126,361
- Stock #:
- 143511
- VIN:
- 3C6UR5FL7LG143511

2020 RAM 2500
Laramie Crew Cab 4WD
126,361 mi
$37,839
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Patriot Blue Pearlcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 114,415
- Stock #:
- P8783
- VIN:
- 3C6UR5DJ1MG655798

2021 RAM 2500
Big Horn Crew Cab 4WD
114,415 mi
$30,072
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 96,186
- Stock #:
- P608562
- VIN:
- 3C6UR5CJXMG608562

2021 RAM 2500
Tradesman Crew Cab 4WD
96,186 mi
$27,497
- Year:
- 2020
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Gray (Granite Crystal Metallic Clearcoat)
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 83,675
- Stock #:
- 19843
- VIN:
- 3C6UR5SL8LG214401

-$2,250
2020 RAM 2500
Limited Crew Cab 4WD
83,675 mi
$50,599
$48,349
CarGurus Analysis:
2021 RAM 2500
With 3,303 currently listed for sale and an average price of $41,407.00, 29.8% of 2021 RAM 2500s for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 RAM 2500 4.69 / 5 stars.
78.1% of 2021 RAM 2500 models on CarGurus are accident free.
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Delmonico Red Pearlcoat
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 115,000
- Stock #:
- TNA1156A
- VIN:
- 3C6UR5FL5MG502288

2021 RAM 2500
Laramie Crew Cab 4WD
115,000 mi
$42,594
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Gray
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 77,325
- Stock #:
- P111332C
- VIN:
- 3C6UR5FL8NG111332

2022 RAM 2500
Laramie Crew Cab 4WD
77,325 mi
$47,768
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 53,366
- Stock #:
- T680565
- VIN:
- 3C6UR5DL2MG680565

2021 RAM 2500
Big Horn Crew Cab 4WD
53,366 mi
$45,199
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 76,134
- Stock #:
- L4686
- VIN:
- 3C6UR5HJ5NG372543

2022 RAM 2500
Tradesman Crew Cab LB 4WD
76,134 mi
$31,494
- Year:
- 2020
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- Gray (Granite Crystal Metallic Clearcoat)
- Fuel type:
- Gasoline
- Interior color:
- Diesel Gray/Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 90,148
- Stock #:
- 208304
- VIN:
- 3C6UR5CJ6LG208304

2020 RAM 2500
Tradesman Crew Cab 4WD
90,148 mi
$30,739
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 61,449
- Stock #:
- P9600
- VIN:
- 3C6UR5CL9NG138883

2022 RAM 2500
Tradesman Crew Cab 4WD
61,449 mi
$40,123
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- 4X2
- Engine:
- 410 hp 6.4L V8
- Exterior color:
- White
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 8-Speed Automatic
- Mileage:
- 119,449
- Stock #:
- 637555
- VIN:
- 3C6UR4CJ1MG637555

2021 RAM 2500
Tradesman Crew Cab RWD
119,449 mi
$21,015
- Year:
- 2020
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- White
- Fuel type:
- Diesel
- Interior color:
- Gray
- Transmission:
- 6-Speed Automatic
- Mileage:
- 83,677
- Stock #:
- 276145
- VIN:
- 3C6UR5CL9LG276145

2020 RAM 2500
Tradesman Crew Cab 4WD
83,677 mi
$34,577
- Year:
- 2021
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Black
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 127,444
- Stock #:
- RO5700
- VIN:
- 3C6UR5FL7MG561035

2021 RAM 2500
Laramie Crew Cab 4WD
127,444 mi
$40,449
- Year:
- 2022
- Make:
- RAM
- Model:
- 2500
- Body type:
- Pickup Truck
- Doors:
- 4 doors
- Drivetrain:
- Four-Wheel Drive
- Engine:
- 370 hp 6.7L I6 Diesel
- Exterior color:
- Bright White Clearcoat
- Fuel type:
- Diesel
- Interior color:
- Black
- Transmission:
- 6-Speed Automatic
- Mileage:
- 61,449
- Stock #:
- P9600
- VIN:
- 3C6UR5CL9NG138883

Sponsored Listing
2022 RAM 2500
Tradesman Crew Cab 4WD
61,449 mi
$40,123
CarGurus Analysis: 2021 RAM 2500

Summary
With 3,303 currently listed for sale and an average price of $41,407.00, 29.8% of 2021 RAM 2500s for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 RAM 2500 4.69 / 5 stars.
78.1% of 2021 RAM 2500 models on CarGurus are accident free.
Why it stands out
The 2021 RAM 2500 is a standout in the heavy-duty truck segment, combining impressive performance with a range of modern features. Owners rave about its powerful engine options, particularly the diesel variant, which offers both exceptional towing capacity and fuel efficiency. The truck's spacious interior is designed for comfort, making it suitable for both work and family use. While some users have noted a desire for more advanced interior technology, the RAM 2500 still provides a solid value for those seeking a reliable and capable truck. With a strong reputation for safety and durability, it remains a top choice among heavy-duty pickups.
Other model years to consider
- Average price: $53,815.00
- Good/great deal percentage: 34.5%
- User rating: 5 / 5
- Total listings: 6,364
- Average price: $40,045.00
- Good/great deal percentage: 30.0%
- User rating: 4.85 / 5
- Total listings: 2,300
- Average price: $51,428.00
- Good/great deal percentage: 37.0%
- User rating: 5 / 5
- Total listings: 3,265
This analysis is based on CarGurus' proprietary market data from August 3, 2026, CarGurus experts' opinions, and generative AI.
4.7 Overall rating
Filter by rating
Anonymous
Reviewed a 2021 RAM Power Wagon Crew Cab 4WD on May 30, 2026
Overal nice vehicle but it had small 17" wheels on it.
Anonymous
Reviewed a 2021 RAM 2500 on Jul 10, 2021
incredible. especially the artificial intelligence features. Updates such as bullet proof glass an added plus. great power and torque from the cummins. easily pushes other cars out of the way. very good to protect against attempted car jackers with the auto extracting prods We love this truck and applaud the RAM people for meeting consumer needs and wants in 2021. Great value. Very safe. Would buy again.
William S
Reviewed a 2021 RAM 2500 on Jan 28, 2022
It’s awesome. I’m glad my Ram 2500 single cab tradesmen 4x4 hemi is capable of doing everything I need. Kudos to Ram for still making a 3/4 ton 4x4 single cab without all the bells and whistles because people like me like basic things.
Anonymous
Reviewed a 2021 RAM 2500 on Mar 14, 2021
It basically drives itself. Fantastic vehicle and very fuel efficient for a huge diesel.
2021 RAM 2500 Trims
| Trim type | MSRP |
|---|---|
| Big Horn Crew Cab LB 4WD | $46,730 |
| Limited Mega Cab 4WD | $67,540 |
| Tradesman Crew Cab LB 4WD | $42,080 |
| Laramie Mega Cab 4WD | $55,240 |
| Power Wagon Crew Cab 4WD | $54,740 |
| Tradesman Crew Cab 4WD | $41,880 |
| Laramie Crew Cab 4WD | $53,740 |
| Big Horn Crew Cab 4WD | $46,530 |
2021 RAM 2500 Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 RAM 2500 prices has changed over time.
See more price trendsHow much does the 2021 RAM 2500 cost?
| Metric | Value |
|---|---|
| Current Average Price | $41,468 |
| Year-Round Low | $41,421.60 |
| Year-Round High | $44,831.12 |
| Average Price a Year Ago | $44,782 |
| Change vs. Last Year | −7.40% |
Prices have softened 7.40% compared to this time last year, making it a favorable time to shop this model year.
There are 3,279 listings available, which suggests you have a meaningful amount of inventory to compare.
If you find a listing below $41,421.60, that's toward the low end of the year-round range and worth acting on quickly.
Is the 2021 RAM 2500 a good car?
Yes — the 2021 RAM 2500 earns a 4.69/5 user rating, which points to strong owner satisfaction. Owners consistently praise its performance, safety features, and value for money, and many highlight the power and fuel efficiency, especially with the diesel engine. It also fits well if you want a heavy-duty truck that can handle work duties while still offering a more comfortable, family-friendly cabin. With 30.1% of listings marked as good or great deals, you have some room to shop selectively.
Is the 2021 RAM 2500 reliable?
Owners rate it 4.69/5, a strong signal of long-term satisfaction.
The owner feedback also points to dependable performance, with repeated praise for its trouble-free feel, strong capability, and confidence-inspiring ownership experience. That kind of long-term approval matters if you plan to keep the truck for years and use it hard. For used buyers, the main risk is less about the model’s reputation and more about how well a specific truck was maintained and used.
What should I look for when buying a used 2021 RAM 2500?
Accident-free inventory is solid at 77.7% — always verify the vehicle history report.
You should still check the history report carefully, because a clean listing percentage does not replace a vehicle-by-vehicle review. Put inspection priority on signs of heavy use, since this is a truck that may have been worked hard. Focus on overall condition, maintenance records, and whether the truck’s wear matches its mileage and intended use.
Is now a good time to buy a used 2021 RAM 2500?
This is a moderate market, so you can shop selectively without expecting every listing to be a bargain.
- Deal availability: 30.1% of listings are priced as good or great deals.
- Inventory: There are 3,279 listings available.
- Price trend: Prices have softened 7.40% compared with last year.
- Clean inventory: 77.7% of listings are accident-free.
If you find a listing below $41,421.60, that's toward the low end of the year-round range and worth acting on quickly.
What is the 2021 RAM 2500's resale value?
The current average of $41,468 sits slightly below last year's $44,782.
That softer pricing can help you buy with less risk of overpaying, but it also means future resale gains may be more limited if the market stays cool. If you buy well now and keep the truck in strong condition, you improve your odds of holding value better than the average listing. Trucks with broad appeal and strong owner satisfaction tend to stay easier to resell when demand is steady.
Vehicles with strong owner satisfaction ratings, like this model year's 4.69/5, tend to retain buyer demand, which supports resale value over time.
Should I buy a 2021 RAM 2500 or consider a different year?
If you're weighing the 2021 against nearby model years, here's how to think about it:
Choose the 2021 if:
- 30.1% of listings are priced as good or great deals.
- Accident-free inventory is solid at 77.7% — always verify the vehicle history report.
- Price trend: Prices have softened 7.40% compared with last year.
- Owners rate it 4.69/5 — a strong satisfaction signal.
Consider the 2020 if:
- At $40,036, the 2020 costs less than the current year's $41,468 average.
- It offers a more upscale cabin and strong tech appeal.
The bottom line: You should lean toward the 2021 if you want the stronger current-market balance of price, inventory, and owner satisfaction. If your priority is spending less up front, the 2020 is the better value-oriented path, especially if its lower average price matters more than the newer-year market position.
These recommendations are based on CarGurus' proprietary market data from July 31, 2026, CarGurus experts' opinions, and generative AI.
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