Used 2021 Lexus RX 350 AWD for SaleNationwide
170 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 80,795
- Stock #:
- F261599A
- VIN:
- 2T2HZMDA3MC290745
2021 Lexus RX
350 AWD
80,795 mi
Freehold, NJ
Good Deal
$32,244
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- Automatic
- Mileage:
- 132,091
- Stock #:
- MC277040
- VIN:
- 2T2HZMDAXMC277040
Price drop
-$800
2021 Lexus RX
350 AWD
132,091 mi
Margate, FL
Good Deal
$24,795
$23,995
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 85,787
- Stock #:
- C265964
- VIN:
- 2T2HZMDA0MC265964
2021 Lexus RX
350 AWD
85,787 mi
Lodi, NJ
Good Deal
$29,977
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Mileage:
- 27,618
- Stock #:
- TMC270198
- VIN:
- 2T2HZMDAXMC270198
New arrival
2021 Lexus RX
350 AWD
27,618 mi
Highlands Ranch, CO
Good Deal
$42,122
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 71,443
- Stock #:
- MC276003
- VIN:
- 2T2HZMDAXMC276003
2021 Lexus RX
350 AWD
71,443 mi
Plano, TX
Good Deal
$34,112
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- MATADOR RED MICA
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- BLACK W/MATTE WALNUT TRIM
- Transmission:
- Automatic
- Mileage:
- 75,292
- Stock #:
- 264407A
- VIN:
- 2T2HZMDA2MC277971
2021 Lexus RX
350 AWD
75,292 mi
Kaukauna, WI
Great Deal
$33,329
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 62,983
- Stock #:
- B20898A
- VIN:
- 2T2AZMDAXMC260286
2021 Lexus RX
350 AWD
62,983 mi
Vancouver, WA
Good Deal
$35,195
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Mileage:
- 90,268
- Stock #:
- G01439B
- VIN:
- JTJHZMDA8M2053359
2021 Lexus RX
350 AWD
90,268 mi
Lindon, UT
Great Deal
$30,749
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,312
- Stock #:
- MC259462
- VIN:
- 2T2HZMDA1MC259462
2021 Lexus RX
350 AWD
70,312 mi
White Hall, AR
Great Deal
$33,900
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,964
- Stock #:
- SV6250A
- VIN:
- 2T2HZMDA4MC284677
2021 Lexus RX
350 AWD
56,964 mi
Raynham, MA
Good Deal
$36,627
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,990
- Stock #:
- TMC301120
- VIN:
- 2T2HZMDA9MC301120
New arrival
2021 Lexus RX
350 AWD
53,990 mi
Columbia, SC
Good Deal
$37,650
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch w/Matte Walnut Trim
- Transmission:
- Automatic
- Mileage:
- 47,151
- Stock #:
- 50790AQ
- VIN:
- 2T2HZMDA9MC258513
2021 Lexus RX
350 AWD
47,151 mi
Everett, WA
Good Deal
$38,099
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- Automatic
- Mileage:
- 45,740
- Stock #:
- T18080A
- VIN:
- 2T2HZMDA9MC270144
2021 Lexus RX
350 AWD
45,740 mi
Kansas City, MO
Good Deal
$41,173
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic Overdrive
- Mileage:
- 40,172
- Stock #:
- JC124251A
- VIN:
- JTJHZMDA6M2053439
2021 Lexus RX
350 AWD
40,172 mi
Jacksonville, FL
Fair Deal
$40,986
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 54,781
- Stock #:
- GMC279901
- VIN:
- 2T2HZMDA2MC279901
New arrival
2021 Lexus RX
350 AWD
54,781 mi
Birmingham, AL
Great Deal
$36,689
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 47,730
- Stock #:
- H12715A
- VIN:
- 2T2JZMDA5MC302539
New arrival
2021 Lexus RX
350 AWD
47,730 mi
Omaha, NE
Fair Deal
$41,224
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 93,599
- Stock #:
- 26725A
- VIN:
- 2T2HZMDA2MC276559
New arrival
2021 Lexus RX
350 AWD
93,599 mi
Northborough, MA
Fair Deal
$32,299
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 71,355
- Stock #:
- 2533C
- VIN:
- 2T2HZMDA4MC289278
2021 Lexus RX
350 AWD
71,355 mi
Levittown, NY
Great Deal
$29,970
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nightfall Mica
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic Overdrive
- Mileage:
- 50,816
- Stock #:
- MC277086A
- VIN:
- 2T2JZMDAXMC277086
New arrival
2021 Lexus RX
350 AWD
50,816 mi
Cincinnati, OH
Fair Deal
$41,198
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 57,401
- Stock #:
- T271706
- VIN:
- 2T2HZMDA8MC271706
2021 Lexus RX
350 AWD
57,401 mi
Terryville, CT
Fair Deal
$38,607
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 32,336
- Stock #:
- UH7232T
- VIN:
- 2T2HZMDA8MC292099
2021 Lexus RX
350 AWD
32,336 mi
New Rochelle, NY
Good Deal
$37,988
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,352
- Stock #:
- LGE280052
- VIN:
- 2T2HZMDAXMC280052
2021 Lexus RX
350 AWD
41,352 mi
Hampstead, MD
Great Deal
$37,498
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 75,464
- Stock #:
- 11-9284
- VIN:
- 2T2AZMDA8MC279340
2021 Lexus RX
350 AWD
75,464 mi
West Bridgewater, MA
Great Deal
$30,996
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 46,443
- Stock #:
- P300490
- VIN:
- 2T2HZMDA4MC297476
2021 Lexus RX
350 AWD
46,443 mi
Valdosta, GA
Good Deal
$38,698
5.0 Overall rating
Filter by rating
Michael B
Reviewed a 2021 Lexus 350 AWD on Sep 18, 2025
Premium package with LTA, SCS, heating/ventilation seating, pre-collision detection, etc.
Is this review helpful?
FAQs
How much does the Lexus RX 350 AWD cost?
The average Lexus RX 350 AWD costs about $36,450.75. The average price has increased by 3.3% since last year. The 2087 for sale on CarGurus range from $2,949 to $59,395 in price.
How many Lexus RX 350 AWD vehicles have no reported accidents or damage?
1314 out of 2087 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX 350 AWD?
Depending on the engine and options, the Lexus RX 350 AWD gets between 19 and 24 MPG (or EV battery range).
What fuel types are available?
Gasoline engines are available.
Relevant articles
CarGurus Editorial Team
Best Lexus Deals in August 2026
Leasing a Lexus can be a great way to get into a new car from one of the most popular luxury brands at a more affordable monthly rate. Here are the best deals we've found this month on Lexus vehicles.
CarGurus Editorial Team
The Best Midsize SUVs in 2026
The midsize SUV segment is growing fast and fiercely competitive. Terrible models are few and far between; what you will find are 50 shades of better or best.
Chris Teague
The Best Used Luxury SUVs in 2026
No matter how you look at it, today’s automotive market is dominated by SUVs, in particular compact SUVs. The "not-a-minivan" family haulers have become so popular and profitable for automakers that many have stopped making cars in favor of building more SUVs in recent years.
Lexus RX 350 AWD in ArizonaLexus RX 350 AWD in ArkansasLexus RX 350 AWD in CaliforniaLexus RX 350 AWD in ColoradoLexus RX 350 AWD in FloridaLexus RX 350 AWD in GeorgiaLexus RX 350 AWD in HawaiiLexus RX 350 AWD in IllinoisLexus RX 350 AWD in IowaLexus RX 350 AWD in KansasLexus RX 350 AWD in MassachusettsLexus RX 350 AWD in MichiganLexus RX 350 AWD in MinnesotaLexus RX 350 AWD in MontanaLexus RX 350 AWD in New HampshireLexus RX 350 AWD in New JerseyLexus RX 350 AWD in New MexicoLexus RX 350 AWD in North CarolinaLexus RX 350 AWD in OregonLexus RX 350 AWD in PennsylvaniaLexus RX 350 AWD in Rhode IslandLexus RX 350 AWD in South CarolinaLexus RX 350 AWD in South DakotaLexus RX 350 AWD in TexasLexus RX 350 AWD in UtahLexus RX 350 AWD in Virginia
All Used CarsManual Transmission CarsLuxury CarsCars with Red InteriorCheap Manual CarsHybrid CarsSports CarsElectric SUVsCheap TrucksSmall CarsThird Row SUVsThree Quarter Ton TrucksLifted TrucksManual Transmission TrucksDiesel TrucksHybrid SUVsDually TrucksOne Ton TrucksCheap SUVsLifted Ford Trucks4x4 TrucksWork TrucksAWD SUVsFord TrucksChevrolet TrucksToyota TrucksTrucks Under $10,000Cars Under $15,000Sports Cars Under $20,000Trucks Under $20,000Used Sedans for Sale with Low MileageUsed SUVs / Crossovers for Sale with Low MileageUsed Hatchbacks for Sale with Low MileageUsed Convertibles for Sale with Low MileageUsed Vans for Sale with Low MileageUsed Minivans for Sale with Low MileageUsed Pickup Trucks for Sale with Low MileageUsed Coupes for Sale with Low MileageUsed Wagons for Sale with Low Mileage
