Used 2021 Lexus RX 350 AWD for SaleNationwide
170 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- MATADOR RED MICA
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- BLACK W/MATTE WALNUT TRIM
- Transmission:
- Automatic
- Mileage:
- 75,292
- Stock #:
- 264407A
- VIN:
- 2T2HZMDA2MC277971
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Price drop
-$1,049
2021 Lexus RX
350 AWD
75,292 mi
Kaukauna, WI
Great Deal
$34,378
$33,329
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 90,896
- Stock #:
- AC00045
- VIN:
- 2T2HZMDA7MC264083
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2021 Lexus RX
350 AWD
90,896 mi
Princeton, NJ
Good Deal
$31,855
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 32,336
- Stock #:
- UH7232T
- VIN:
- 2T2HZMDA8MC292099
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Price drop
-$1,120
2021 Lexus RX
350 AWD
32,336 mi
New Rochelle, NY
Good Deal
$39,108
$37,988
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- Automatic
- Mileage:
- 27,342
- Stock #:
- LP7158
- VIN:
- 2T2AZMDAXMC267058
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2021 Lexus RX
350 AWD
27,342 mi
Lakeland, FL
Fair Deal
$40,745
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 65,116
- Stock #:
- K0415
- VIN:
- 2T2AZMDA8MC262165
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2021 Lexus RX
350 AWD
65,116 mi
Draper, UT
Good Deal
$34,594
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Mileage:
- 27,618
- Stock #:
- TMC270198
- VIN:
- 2T2HZMDAXMC270198
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New arrival
2021 Lexus RX
350 AWD
27,618 mi
Highlands Ranch, CO
Good Deal
$42,122
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 62,983
- Stock #:
- B20898A
- VIN:
- 2T2AZMDAXMC260286
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2021 Lexus RX
350 AWD
62,983 mi
Vancouver, WA
Good Deal
$35,195
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Matador Red Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Mileage:
- 90,268
- Stock #:
- G01439B
- VIN:
- JTJHZMDA8M2053359
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2021 Lexus RX
350 AWD
90,268 mi
Lindon, UT
Great Deal
$30,250
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 72,068
- Stock #:
- MC308401
- VIN:
- 2T2AZMDA6MC308401
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2021 Lexus RX
350 AWD
72,068 mi
Port Orchard, WA
Fair Deal
$35,381
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,964
- Stock #:
- SV6250A
- VIN:
- 2T2HZMDA4MC284677
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2021 Lexus RX
350 AWD
56,964 mi
Raynham, MA
Good Deal
$36,627
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,936
- Stock #:
- XBP8596
- VIN:
- 2T2HZMDA0MC304360
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2021 Lexus RX
350 AWD
41,936 mi
Libertyville, IL
Fair Deal
$39,930
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 53,399
- Stock #:
- 26H1433B
- VIN:
- 2T2HZMDAXMC275188
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2021 Lexus RX
350 AWD
53,399 mi
Nashua, NH
Good Deal
$35,903
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 47,809
- Stock #:
- XBP8599
- VIN:
- 2T2HZMDA9MC266174
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2021 Lexus RX
350 AWD
47,809 mi
Libertyville, IL
Good Deal
$38,461
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 71,443
- Stock #:
- MC276003
- VIN:
- 2T2HZMDAXMC276003
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2021 Lexus RX
350 AWD
71,443 mi
Plano, TX
Fair Deal
$35,176
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- Automatic
- Mileage:
- 132,091
- Stock #:
- MC277040
- VIN:
- 2T2HZMDAXMC277040
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Price drop
-$800
2021 Lexus RX
350 AWD
132,091 mi
Margate, FL
Good Deal
$24,795
$23,995
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nebula Gray Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch w/Matte Walnut Trim
- Transmission:
- Automatic
- Mileage:
- 47,151
- Stock #:
- 50790AQ
- VIN:
- 2T2HZMDA9MC258513
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2021 Lexus RX
350 AWD
47,151 mi
Everett, WA
Good Deal
$38,099
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 81,254
- Stock #:
- LM12001
- VIN:
- 2T2HZMDAXMC295862
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2021 Lexus RX
350 AWD
81,254 mi
Merrillville, IN
Fair Deal
$34,235
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 75,464
- Stock #:
- 11-9284
- VIN:
- 2T2AZMDA8MC279340
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2021 Lexus RX
350 AWD
75,464 mi
West Bridgewater, MA
Great Deal
$30,996
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,312
- Stock #:
- MC259462
- VIN:
- 2T2HZMDA1MC259462
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2021 Lexus RX
350 AWD
70,312 mi
White Hall, AR
Great Deal
$33,900
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 56,496
- Stock #:
- TC275155
- VIN:
- 2T2HZMDA6MC275155
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New arrival
2021 Lexus RX
350 AWD
56,496 mi
Rockville, MD
Fair Deal
$38,797
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Glazed Caramel
- Transmission:
- 8-Speed Automatic
- Mileage:
- 46,443
- Stock #:
- P300490
- VIN:
- 2T2HZMDA4MC297476
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2021 Lexus RX
350 AWD
46,443 mi
Valdosta, GA
Good Deal
$38,698
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Nightfall Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 55,993
- Stock #:
- W10102A
- VIN:
- 2T2HZMDA3MC278398
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New arrival
2021 Lexus RX
350 AWD
55,993 mi
Willow Grove, PA
Fair Deal
$37,983
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 48,353
- Stock #:
- LL4340A
- VIN:
- 2T2HZMDAXMC290239
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New arrival
2021 Lexus RX
350 AWD
48,353 mi
State College, PA
Fair Deal
$38,480
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Red
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Tan)
- Transmission:
- Automatic
- Mileage:
- 53,371
- Stock #:
- 8H2JFH
- VIN:
- 2T2HZMDA3MC283780
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Price drop
-$1,600
2021 Lexus RX
350 AWD
53,371 mi
Mechanicsburg, PA
Great Deal
$36,898
$35,298
5.0 Overall rating
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Michael B
Reviewed a 2021 Lexus 350 AWD on Sep 18, 2025
Premium package with LTA, SCS, heating/ventilation seating, pre-collision detection, etc.
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FAQs
How much does the Lexus RX 350 AWD cost?
The average Lexus RX 350 AWD costs about $36,491.83. The average price has increased by 3.3% since last year. The 2047 for sale on CarGurus range from $3,449 to $59,395 in price.
How many Lexus RX 350 AWD vehicles have no reported accidents or damage?
1297 out of 2047 for sale have no reported accidents or damage.
What is the fuel economy of the Lexus RX 350 AWD?
Depending on the engine and options, the Lexus RX 350 AWD gets between 19 and 24 MPG (or EV battery range).
What fuel types are available?
Gasoline engines are available.
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