The 2006 TSX saw some design changes from the 2005 model, including new front fascia, integrated foglights, and new rear fascia, including restyled taillights. A redesigned grill and new side-marker lights give the 2006 TSX a more aerodynamic look.

The 2.4-liter I4 was tuned to produce 205 horsepower (compliant with the new SAE means of measuring) and 164 lb-ft of torque. The 2006 TSX is available with two transmissions, a 5-speed automatic and a 6-speed manual. The automatic gets 22/31 mileage, while the manual achieves 22/30. Both require the use of premium fuel.

The 2006 TSX continues to impress with a variety of standard features, including a sunroof, leather seats, and power seats, locks, and windows.

Drivers love the reliability and strong build of the 2006 TSX. They also like the gas efficiency and the overall look of the car. There are very few complaints about the 2006 TSX, mostly centered on a lack of torque.