Multiple cylinder missfire

Had the same problem in my 05 Durango with the 4.7, in my case it was the plastic tensioners for the timing chains. When they wear they allow too much slack in the chains and you get "random multiple misfires". (My engine would even cut off when knock sensor kicked in.) In your case I would check timing, knock sensor, lifters, and valve lash. With valve covers off or via cap & rotor a mechanic can check how much slack there is in timing chain, if it's excessive the tensioners may need replaced. The factory does not consider those serviceable parts, meaning those are meant to last life of the engine, and if they fail engine should be rebuilt. Others will also say if you are going to replace the tensioners you should replace sprockets as well. Tensioners and chains in my case were $80 in parts, if I had replaced sprockets as well, that would have been over 400 in parts. And of course an engine rebuild would have been thousands more. So look at the simple and easy to replace parts first (sensors, cap, rotor, tune up), then items like lifters, valves, then look at timing chain & tensioners. (A mechanics bore scope can also get in there to see what shape they're in.)

I keep getting a c1 misfire and we have already changed all the spark plug on my 06 durango and the c1 coil and it misses a little not bad but still misses so when the check engine light came on it came back the c1 misfire what else can it be if my husband as already changed all the spark plugs and that c1 coil