Used 2022 Mercedes-Benz E-Class for Sale nearTampa, FL

Compare 2022 Mercedes-Benz E-Class Trims in Tampa, FL

The E-Class offers a blend of luxury and performance, with options ranging from fuel-efficient sedans to stylish coupes.

• Starting at $36,498
• Best MPG/MPGe: 23 city / 31 hwy
• Most Popular: E 350 4MATIC

Trim Overview

Prices updated weekly from CarGurus listings.

Quick Compare Table

Listing prices sourced from CarGurus — updated weekly. OEM specs from manufacturer data.

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Trim Deep Dives

E 350 RWD — "Who It's For"

The E 350 RWD is the pick for shoppers who want a luxury sedan experience without the AWD price premium.

• Avg. market price: $36,585 (updated weekly)
• MPG/MPGe: 23 city / 31 hwy
• Inventory: 89 listings
• View E 350 RWD listings

E 350 4MATIC — "Who It's For"

The E 350 4MATIC is the pick for shoppers who want all-wheel drive without sacrificing luxury features.

• Avg. market price: $42,123 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 96 listings
• View E 350 4MATIC listings

E 450 4MATIC Sedan AWD — "Who It's For"

The E 450 4MATIC Sedan AWD is the pick for shoppers who want a powerful engine and luxury features in an AWD package.

• Avg. market price: $42,123 (updated weekly)
• MPG/MPGe: 23 city / 30 hwy
• Inventory: 27 listings
• View E 450 4MATIC Sedan AWD listings

E 450 Coupe RWD — "Who It's For"

The E 450 Coupe RWD is the pick for shoppers who want a stylish coupe with premium features without the AWD cost.

• Avg. market price: $42,123 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 18 listings — lower availability; may limit negotiating room
• View E 450 Coupe RWD listings

E 450 4MATIC Coupe AWD — "Who It's For"

The E 450 4MATIC Coupe AWD is the pick for shoppers who want a luxury coupe with all-wheel drive and premium amenities.

• Avg. market price: $42,123 (updated weekly)
• MPG/MPGe: 21 city / 30 hwy
• Inventory: 12 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Coupe AWD listings

E 450 Cabriolet RWD — "Who It's For"

The E 450 Cabriolet RWD is the pick for shoppers who want a convertible experience with luxury features at a competitive price.

• Avg. market price: $36,498 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 12 listings — lower availability; may limit negotiating room
• View E 450 Cabriolet RWD listings

AMG E 53 Sedan 4MATIC — "Who It's For"

The AMG E 53 Sedan 4MATIC is the pick for shoppers who want sporty performance combined with luxury features.

• Avg. market price: $36,995 (updated weekly)
• MPG/MPGe: 21 city / 29 hwy
• Inventory: 5 listings — lower availability; may limit negotiating room
• View AMG E 53 Sedan 4MATIC listings

E 450 4MATIC Cabriolet AWD — "Who It's For"

The E 450 4MATIC Cabriolet AWD is the pick for shoppers who want a luxury convertible with all-wheel drive and premium features.

• Avg. market price: $42,123 (updated weekly)
• MPG/MPGe: 22 city / 29 hwy
• Inventory: 11 listings — lower availability; may limit negotiating room
• View E 450 4MATIC Cabriolet AWD listings

Trim Recommendations

Most Popular — E 350 4MATIC

With 96 active listings, the E 350 4MATIC is the clear volume leader in the lineup.

Browse E 350 4MATIC listings

Best Budget Option — E 450 Cabriolet RWD

At $36,498 avg market price — below the lineup median of $42,123 — it's the most accessible entry point.

Browse E 450 Cabriolet RWD listings

Best for Fuel Economy — E 350 RWD

The E 350 RWD offers the best fuel economy in the lineup with 23/31 MPG.

Browse E 350 RWD listings

These recommendations are based on CarGurus' proprietary market data from September 12, 2026, CarGurus experts' opinions, and generative AI.

How much does the 2022 Mercedes-Benz E-Class cost?

Prices have softened 7.48% compared to this time last year, making it a favorable time to shop this model year.

There are 1,028 listings available, which gives you a meaningful amount of inventory to compare.

Is the 2022 Mercedes-Benz E-Class a good car?

Yes — the 2022 Mercedes-Benz E-Class earns 5/5 from users and 8.17/10 from our experts. The standout strength is Safety at 10/10.

The 2022 model keeps the refreshed look and feel from the prior update, and it leans into comfort, style, and upscale presentation rather than a major redesign. It also stands out for offering a Cabriolet body style, which gives you a more distinctive open-air option than many rivals.

34.0% of listings are priced as good or great deals, which suggests there are still some attractive opportunities if you shop carefully.

Is the 2022 Mercedes-Benz E-Class reliable?

Owners rate it 5/5, a strong signal of long-term satisfaction.

The 2022 E-Class is presented as a refined luxury car with a strong emphasis on comfort, convenience, and a high-end cabin. Its turbocharged four-cylinder and six-cylinder power plants, along with the updated 2021-era refresh, point to a lineup that is more about polished everyday use than dramatic mechanical change.

The performance notes also emphasize a robust response to throttle input, with the turbo-six and mild-hybrid setup delivering strong power across much of the rev range. On the ownership side, the car’s premium positioning means upkeep can be costly, so long-term risk for used buyers is less about basic durability and more about staying ahead of expensive maintenance and option-related repairs.

What should I look for when buying a used 2022 Mercedes-Benz E-Class?

Accident-free inventory is solid at 83.9% — always verify the vehicle history report.

You should still check the history report carefully, because even a strong accident-free share does not guarantee the individual car you’re considering has a clean past. Prioritize a pre-purchase inspection that focuses on the convertible top, electronics, and any signs of wear in the cabin and suspension. Since this model is positioned as a luxury car with lots of equipment, condition matters as much as mileage.

Key things to evaluate:

• Trim level: The lineup spans coupe, convertible, sedan, and station wagon body styles, and the E350, E450, and AMG E53 variants each bring a different personality. The E350 is the more understated choice, while the E450 adds the turbo 3.0-liter inline-six with EQ Boost, and the AMG E53 brings the most performance-focused setup. If you want the best-value balance, the E450 is the trim to focus on because it keeps the luxury and tech while avoiding the highest sticker shock.
• Powertrain: You’ll find a turbocharged four-cylinder in the E350 and a turbo 3.0-liter inline-six with EQ Boost mild-hybrid technology in the E450 and AMG E53. The performance setup uses a 48-volt electrical system and an integrated starter generator to improve power output and efficiency.
• Safety package: Standard equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Driver Assistance Package adds adaptive cruise control with Active Speed Limit Assist, Active Steering Assist, front automatic braking for cross traffic, Evasive Steering Assist, Active Lane Keeping Assist, Active Blind Spot Assist, Active Emergency Stop Assist, and Pre Safe Plus.
• Infotainment: The cabin uses Mercedes-Benz User Experience with two 12.3-inch screens, including a touchscreen and digital instrument cluster. Apple CarPlay and Android Auto are included, and WiFi service plus augmented reality navigation are available.
• Fuel efficiency: The mild-hybrid setup is designed to improve efficiency, though no MPG figure is stated here.

Which 2022 Mercedes-Benz E-Class trim should I buy?

The 2022 Mercedes-Benz E-Class is offered in 3 trim levels: E350, E450, AMG E53.

Here's the short version:

• E350: This is the entry point if you want the E-Class experience with the turbocharged four-cylinder engine and the core luxury features. It makes the most sense if you care more about comfort and style than maximum power.
• E450: This is the best-value choice because it adds the turbo 3.0-liter inline-six with EQ Boost while keeping the E-Class’s upscale cabin and broad feature set. If you want the sweet spot between performance and price, this is the one to target.
• AMG E53: Choose this if you want the most performance-oriented version in the lineup, with the AMG-tuned inline-six, stronger acceleration, and more aggressive driving character. It suits you best if you want the E-Class to feel genuinely sporty.

The Driver Assistance Package is the key safety upgrade to look for if you want the fullest set of driver aids.

Is now a good time to buy a used 2022 Mercedes-Benz E-Class?

This looks like a moderate, selective buyer’s market, so you can shop with some leverage if you’re patient.

• Deal availability: 34.0% of listings are priced as good or great deals.
• Inventory: There are 1,028 listings available.
• Price trend: Prices have softened 7.48% compared with last year.
• Clean inventory: 83.9% of listings are accident-free.

If you find a listing below $39,758, that's toward the low end of the year-round range and worth acting on quickly.

What is the 2022 Mercedes-Benz E-Class's resale value?

The current average of $39,758 sits slightly below last year's $42,972.

That decline suggests the market has already adjusted downward, which can help you as a buyer today but may temper near-term resale gains if you plan to sell soon. If you buy at or below the current average, you reduce the chance of taking an immediate depreciation hit. The year’s relatively stable range also suggests values are not swinging wildly, which is helpful if you want predictable ownership costs.

Vehicles with strong owner satisfaction ratings, like this model year's 5/5, tend to retain buyer demand, which supports resale value over time.

Is the 2022 Mercedes-Benz E-Class safe?

The 2022 Mercedes-Benz E-Class earns a Top Safety Pick+ rating from IIHS and five-star ratings from NHTSA.

It earns a 10/10 safety score from our experts.

Standard safety equipment includes forward collision warning with pedestrian detection, automatic emergency braking, blind-spot monitoring, rear cross-traffic alert, Mercedes Pre Safe, and Pre Safe Sound. The Cabriolet also adds pop-up rollbars for rollover protection, and the Driver Assistance Package brings adaptive cruise control, lane-centering assistance, lane-keeping support, blind-spot assist, evasive steering assist, and rear-collision preparation.

Should I buy a 2022 Mercedes-Benz E-Class or consider a different year?

If you're weighing the 2022 against nearby model years, here's how to think about it:

Choose the 2022 if:

• 34.0% of listings are priced as good or great deals.
• Accident-free inventory is solid at 83.9% — always verify the vehicle history report.
• Price trend: Prices have softened 7.48% compared with last year.
• Owners rate it 5/5 — a strong satisfaction signal.
• It keeps the refreshed look and feel while adding standard automatic high-beam headlights and rear USB charging ports on coupe and convertible body styles.

Consider the 2021 if:

• At $36,020, the 2021 costs less than the current year's $39,758 average.
• It offers a broad mix of body styles, engines, and color choices.

The bottom line: If you want the updated 2022 E-Class with its strong safety score, solid deal availability, and distinctive Cabriolet appeal, this is the better all-around pick. If your priority is spending less up front, the 2021 is the smarter value play because it delivers much of the same core appeal for less money.

These recommendations are based on CarGurus' proprietary market data from September 15, 2026, CarGurus experts' opinions, and generative AI.