Used 2021 Mercedes-Benz CLS 450 4MATIC for SaleNationwide
16 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Designo Diamond White Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,143
- Stock #:
- MA089756
- VIN:
- W1K2J5KB4MA089756
Price drop
-$2,549
2021 Mercedes-Benz CLS
450 4MATIC
36,143 mi
Oklahoma City, OK
Great Deal
$40,151
$37,602
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (designo MANUFAKTUR Graphite Metallic)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,710
- Stock #:
- 095079
- VIN:
- W1K2J5KB7MA095079
2021 Mercedes-Benz CLS
450 4MATIC
49,710 mi
Union City, NJ
Good Deal
$35,890
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,603
- Stock #:
- MA086615
- VIN:
- W1K2J5KB4MA086615
New arrival
2021 Mercedes-Benz CLS
450 4MATIC
58,603 mi
Granbury, TX
Fair Deal
$39,100
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Marsala Brown/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,912
- Stock #:
- PM086481
- VIN:
- W1K2J5KB9MA086481
2021 Mercedes-Benz CLS
450 4MATIC
49,912 mi
Pleasantville, NJ
Good Deal
$35,445
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 2,981
- Stock #:
- 890409
- VIN:
- W1K2J5KB3MA090929
2021 Mercedes-Benz CLS
450 4MATIC
2,981 mi
Colorado Springs, CO
Great Deal
$46,488
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray ([992] Selenite Grey Metallic)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 3,118
- VIN:
- W1K2J5KB1MA091836
![Gray ([992] Selenite Grey Metallic) 2021 Mercedes-Benz CLS Coupe All-Wheel Drive Automatic](https://static.cargurus.com/images/forsale/2026/01/13/00/58/2021_mercedes-benz_cls-pic-832979311599051558-1024x768.jpeg?io=true&width=640&height=480&fit=bounds&format=jpg&auto=webp)
2021 Mercedes-Benz CLS
450 4MATIC
3,118 mi
Mooresville, NC
Great Deal
$37,950
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 22,433
- Stock #:
- 085996
- VIN:
- W1K2J5KB4MA085996
2021 Mercedes-Benz CLS
450 4MATIC
22,433 mi
Wilmington, NC
Great Deal
$40,489
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Java
- Transmission:
- Automatic
- Mileage:
- 57,080
- Stock #:
- MA086713
- VIN:
- W1K2J5KB4MA086713
2021 Mercedes-Benz CLS
450 4MATIC
57,080 mi
Paterson, NJ
Good Deal
$31,490
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,407
- Stock #:
- W14927
- VIN:
- W1K2J5KB0MA091827
New arrival
2021 Mercedes-Benz CLS
450 4MATIC
52,407 mi
Williamsburg, VA
Fair Deal
$37,674
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Arabian Grey)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Buckskin Nappa Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,932
- Stock #:
- L2593A
- VIN:
- W1K2J5KB5MA089328
Photos coming soon
2021 Mercedes-Benz CLS
450 4MATIC
58,932 mi
Tuscaloosa, AL
Fair Deal
$39,566
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,838
- Stock #:
- S0174
- VIN:
- W1K2J5KB7MA091890
2021 Mercedes-Benz CLS
450 4MATIC
45,838 mi
Columbia, SC
Great Deal
$35,347
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 32,919
- Stock #:
- 29115337
- VIN:
- W1K2J5KB7MA092960
2021 Mercedes-Benz CLS
450 4MATIC
32,919 mi
Wayne, NJ
Fair Deal
$40,998
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,979
- Stock #:
- 57952W
- VIN:
- W1K2J5KB5MA089765
2021 Mercedes-Benz CLS
450 4MATIC
44,979 mi
Great Neck, NY
Great Deal
$32,670
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 88,194
- Stock #:
- 082279
- VIN:
- W1K2J5KB5MA082279
2021 Mercedes-Benz CLS
450 4MATIC
88,194 mi
Miramar, FL
No Rating
$31,500
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 39,265
- Stock #:
- 089760
- VIN:
- W1K2J5KB6MA089760
2021 Mercedes-Benz CLS
450 4MATIC
39,265 mi
Woodside, NY
No Rating
$45,900
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,757
- Stock #:
- 086735B
- VIN:
- W1K2J5KB3MA086735
2021 Mercedes-Benz CLS
450 4MATIC
41,757 mi
Springfield, IL
High Priced
$43,312
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Designo Diamond White Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 36,143
- Stock #:
- MA089756
- VIN:
- W1K2J5KB4MA089756
Price drop
-$2,549
2021 Mercedes-Benz CLS
450 4MATIC
36,143 mi
Oklahoma City, OK
Great Deal
$40,151
$37,602
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (designo MANUFAKTUR Graphite Metallic)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,710
- Stock #:
- 095079
- VIN:
- W1K2J5KB7MA095079
2021 Mercedes-Benz CLS
450 4MATIC
49,710 mi
Union City, NJ
Good Deal
$35,890
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Graphite Gray Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,603
- Stock #:
- MA086615
- VIN:
- W1K2J5KB4MA086615
New arrival
2021 Mercedes-Benz CLS
450 4MATIC
58,603 mi
Granbury, TX
Fair Deal
$39,100
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Obsidian Black Metallic
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Marsala Brown/Espresso Brown
- Transmission:
- 9-Speed Automatic
- Mileage:
- 49,912
- Stock #:
- PM086481
- VIN:
- W1K2J5KB9MA086481
2021 Mercedes-Benz CLS
450 4MATIC
49,912 mi
Pleasantville, NJ
Good Deal
$35,445
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 2,981
- Stock #:
- 890409
- VIN:
- W1K2J5KB3MA090929
2021 Mercedes-Benz CLS
450 4MATIC
2,981 mi
Colorado Springs, CO
Great Deal
$46,488
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray ([992] Selenite Grey Metallic)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 3,118
- VIN:
- W1K2J5KB1MA091836
2021 Mercedes-Benz CLS
450 4MATIC
3,118 mi
Mooresville, NC
Great Deal
$37,950
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 22,433
- Stock #:
- 085996
- VIN:
- W1K2J5KB4MA085996
2021 Mercedes-Benz CLS
450 4MATIC
22,433 mi
Wilmington, NC
Great Deal
$40,489
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Java
- Transmission:
- Automatic
- Mileage:
- 57,080
- Stock #:
- MA086713
- VIN:
- W1K2J5KB4MA086713
2021 Mercedes-Benz CLS
450 4MATIC
57,080 mi
Paterson, NJ
Good Deal
$31,490
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Blue
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 52,407
- Stock #:
- W14927
- VIN:
- W1K2J5KB0MA091827
New arrival
2021 Mercedes-Benz CLS
450 4MATIC
52,407 mi
Williamsburg, VA
Fair Deal
$37,674
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray (Arabian Grey)
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Buckskin Nappa Leather
- Transmission:
- 9-Speed Automatic
- Mileage:
- 58,932
- Stock #:
- L2593A
- VIN:
- W1K2J5KB5MA089328
Photos coming soon
2021 Mercedes-Benz CLS
450 4MATIC
58,932 mi
Tuscaloosa, AL
Fair Deal
$39,566
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 45,838
- Stock #:
- S0174
- VIN:
- W1K2J5KB7MA091890
2021 Mercedes-Benz CLS
450 4MATIC
45,838 mi
Columbia, SC
Great Deal
$35,347
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Black
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 32,919
- Stock #:
- 29115337
- VIN:
- W1K2J5KB7MA092960
2021 Mercedes-Benz CLS
450 4MATIC
32,919 mi
Wayne, NJ
Fair Deal
$40,998
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Silver
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 44,979
- Stock #:
- 57952W
- VIN:
- W1K2J5KB5MA089765
2021 Mercedes-Benz CLS
450 4MATIC
44,979 mi
Great Neck, NY
Great Deal
$32,670
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- Gray
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 88,194
- Stock #:
- 082279
- VIN:
- W1K2J5KB5MA082279
2021 Mercedes-Benz CLS
450 4MATIC
88,194 mi
Miramar, FL
No Rating
$31,500
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- designo Diamond White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 39,265
- Stock #:
- 089760
- VIN:
- W1K2J5KB6MA089760
2021 Mercedes-Benz CLS
450 4MATIC
39,265 mi
Woodside, NY
No Rating
$45,900
- Year:
- 2021
- Make:
- Mercedes-Benz
- Model:
- CLS
- Body type:
- Coupe
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 362 hp 3L I6
- Exterior color:
- White
- Combined gas mileage:
- 25 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 41,757
- Stock #:
- 086735B
- VIN:
- W1K2J5KB3MA086735
2021 Mercedes-Benz CLS
450 4MATIC
41,757 mi
Springfield, IL
High Priced
$43,312
FAQs
How much does the Mercedes-Benz CLS 450 4MATIC cost?
The average Mercedes-Benz CLS 450 4MATIC costs about $38,911.95. The average price has increased by 0% since last year. The 173 for sale on CarGurus range from $18,871 to $62,593 in price.
How many Mercedes-Benz CLS 450 4MATIC vehicles have no reported accidents or damage?
134 out of 173 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz CLS 450 4MATIC?
Depending on the engine and options, the Mercedes-Benz CLS 450 4MATIC gets between 25 and 26 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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