Used 2021 Lexus RX for Sale nearIndianapolis, IN
97 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2020
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Obsidian)
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 74,079
- Stock #:
- K151519
- VIN:
- 2T2HZMAA8LC151519
Sponsored by AutoGiant USA
2020 Lexus RX
350 FWD
74,079 mi
$32,245
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,645
- Stock #:
- J8957
- VIN:
- 2T2YZMDA0NC348957
Sponsored Listing
2022 Lexus RX
350 F Sport Handling AWD
44,645 mi
$45,099
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 76,338
- Stock #:
- 261400A
- VIN:
- 2T2HZMDA2NC342769
Sponsored Listing
2022 Lexus RX
350 AWD
76,338 mi
$34,399
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 76,338
- Stock #:
- 261400A
- VIN:
- 2T2HZMDA2NC342769
2022 Lexus RX
350 AWD
76,338 mi
$34,399
- Year:
- 2020
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- 8-Speed Automatic
- Mileage:
- 49,677
- Stock #:
- 161094
- VIN:
- 2T2HZMAA8LC161094
2020 Lexus RX
350 FWD
49,677 mi
$35,809
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,885
- Stock #:
- 28826725
- VIN:
- JTJJZKEA3N2026964
2022 Lexus RX
350L Luxury FWD
44,885 mi
$46,697
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,645
- Stock #:
- J8957
- VIN:
- 2T2YZMDA0NC348957
2022 Lexus RX
350 F Sport Handling AWD
44,645 mi
$45,099
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 64,268
- Stock #:
- GDT1968A
- VIN:
- 2T2HZMDA2NC321369
2022 Lexus RX
350 AWD
64,268 mi
$36,017
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Transmission:
- 8-Speed Automatic
- Mileage:
- 47,438
- Stock #:
- 207994
- VIN:
- 2T2HZMAAXMC207994
2021 Lexus RX
350 FWD
47,438 mi
$34,405
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Gray
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- Automatic
- Mileage:
- 44,847
- Stock #:
- CVLC0292
- VIN:
- 2T2YZMDA3MC290292
2021 Lexus RX
350 F Sport Handling AWD
44,847 mi
$39,689
- Year:
- 2020
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment w/Matte Bamboo Trim)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 52,361
- Stock #:
- 181996
- VIN:
- 2T2HZMAA5LC181996
2020 Lexus RX
350 FWD
52,361 mi
$35,300
- Year:
- 2020
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Pearl White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- White
- Transmission:
- Automatic
- Mileage:
- 113,120
- Stock #:
- 12079
- VIN:
- 2T2AZMAA0LC168638
2020 Lexus RX
350 FWD
113,120 mi
$28,499
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Red
- Transmission:
- 8-Speed Automatic
- Mileage:
- 24,483
- Stock #:
- 18452
- VIN:
- 2T2SZMDA5NC341671
2022 Lexus RX
350 F Sport AWD
24,483 mi
$43,104
CarGurus Analysis:
2021 Lexus RX
With 100 currently listed for sale near Indianapolis, IN and an average price of $39,126.00, 60.0% of 2021 Lexus RX models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Lexus RX 4.92 / 5 stars.
100.0% of 2021 RX models on CarGurus are accident free.
The 2021 Lexus RX continues to impress with its luxurious features, smooth driving experience, and a strong reputation for reliability.
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Eminent White Pearl
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 44,048
- Stock #:
- 60864B
- VIN:
- 2T2HZMDA4NC352896
2022 Lexus RX
350 AWD
44,048 mi
$39,439
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Silver
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 58,125
- Stock #:
- P2725
- VIN:
- 2T2YZMDA1NC312856
2022 Lexus RX
350 F Sport Handling AWD
58,125 mi
$42,272
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,980
- Stock #:
- 9P5419
- VIN:
- JTJHZKFA1N2036289
2022 Lexus RX
350L AWD
70,980 mi
$36,586
- Year:
- 2020
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 8-Speed Automatic
- Mileage:
- 84,707
- Stock #:
- CS10432W
- VIN:
- JTJHZKFA5L2023140
2020 Lexus RX
350L AWD
84,707 mi
$31,805
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Black
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 51,144
- Stock #:
- 249714
- VIN:
- 2T2HZMAAXNC249714
2022 Lexus RX
350 FWD
51,144 mi
$41,007
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 44,920
- Stock #:
- Y6248
- VIN:
- JTJHZKFA0M2028490
2021 Lexus RX
350L AWD
44,920 mi
$39,597
- Year:
- 2021
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Mica
- Combined gas mileage:
- 22 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black Leather
- Transmission:
- Automatic
- Mileage:
- 40,405
- Stock #:
- P12304
- VIN:
- 2T2AZMDAXMC282384
2021 Lexus RX
350 AWD
40,405 mi
$39,577
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- White
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray
- Transmission:
- Automatic
- Mileage:
- 63,339
- Stock #:
- 256909
- VIN:
- 2T2HZMAA0NC256090
2022 Lexus RX
350 FWD
63,339 mi
$39,027
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- Front-Wheel Drive
- Engine:
- 295 hp 3.5L V6
- Exterior color:
- Atomic Silver
- Combined gas mileage:
- 23 MPG
- Fuel type:
- Gasoline
- Interior color:
- Birch
- Transmission:
- 8-Speed Automatic
- Mileage:
- 76,944
- Stock #:
- DNC234693
- VIN:
- 2T2HZMAA8NC234693
2022 Lexus RX
350 FWD
76,944 mi
$37,550
- Year:
- 2022
- Make:
- Lexus
- Model:
- RX
- Body type:
- SUV / Crossover
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 290 hp 3.5L V6
- Exterior color:
- Black (Caviar)
- Combined gas mileage:
- 21 MPG
- Fuel type:
- Gasoline
- Interior color:
- White (Parchment)
- Transmission:
- 8-Speed Automatic
- Mileage:
- 70,980
- Stock #:
- 9P5419
- VIN:
- JTJHZKFA1N2036289
Sponsored Listing
2022 Lexus RX
350L AWD
70,980 mi
$36,586
CarGurus Analysis: 2021 Lexus RX
overall
Summary
With 100 currently listed for sale near Indianapolis, IN and an average price of $39,126.00, 60.0% of 2021 Lexus RX models for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Lexus RX 4.92 / 5 stars.
100.0% of 2021 RX models on CarGurus are accident free.
The 2021 Lexus RX continues to impress with its luxurious features, smooth driving experience, and a strong reputation for reliability.
Why it stands out
The 2021 Lexus RX remains a top contender in the luxury SUV market, known for its exceptional ride quality and comfort. With a powerful 3.5-liter V6 engine producing 295 horsepower, it offers a smooth and capable driving experience, making it ideal for both city and highway driving. The RX is equipped with a host of luxurious features, including a well-appointed interior with high-quality materials and advanced technology options. Notably, the RX has received upgrades in safety technology, ensuring peace of mind for drivers and passengers alike. While some may find the performance fairly pedestrian compared to sportier competitors, the RX excels in comfort and value, making it a compelling choice for those seeking a reliable and luxurious SUV.
Other model years to consider
- Average price: $46,573.00
- Good/great deal percentage: 70.3%
- User rating: 5 / 5
- Total listings: 158
- Average price: $40,883.00
- Good/great deal percentage: 59.9%
- User rating: 4.75 / 5
- Total listings: 147
- Average price: $37,758.00
- Good/great deal percentage: 62.5%
- User rating: 4.88 / 5
- Total listings: 88
This analysis is based on CarGurus' proprietary market data from July 7, 2026, CarGurus experts' opinions, and generative AI.
5.0 Overall rating
Filter by rating
Michael B
Reviewed a 2021 Lexus 350 AWD on Sep 18, 2025
Premium package with LTA, SCS, heating/ventilation seating, pre-collision detection, etc.
Archie C
Reviewed a 2021 Lexus RX on Oct 14, 2024
Very reliable stylish looking drives well. Good suspension. Fun to drive
Mike R
Reviewed a 2021 Lexus RX on Oct 9, 2025
Love the car, smooth power delivery and a solid platform. A few minor cosmetics and a set of Michelin tires and it's perfect with 27k miles.
Ann W
Reviewed a 2021 Lexus RX on Feb 22, 2023
This car is beautiful and drives so smooth.
2021 Lexus RX Trims
| Trim type | MSRP |
|---|---|
| 350L Luxury FWD | $54,050 |
| 350L Luxury AWD | $55,450 |
| 350L FWD | $48,050 |
| 350L AWD | $49,450 |
| 350 F Sport AWD | $50,100 |
| 350 F Sport Handling AWD | $52,500 |
| 350 AWD | $46,620 |
| 350 FWD | $45,220 |
2021 Lexus RX Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Lexus RX prices has changed over time.
See more price trendsFAQs
How much does the 2021 Lexus RX cost in Indianapolis, IN?
Is the 2021 Lexus RX a good car?
How many 2021 Lexus RX vehicles in Indianapolis, IN have no reported accidents or damage?
Is the 2021 Lexus RX safe?
What is the fuel economy of the 2021 Lexus RX?
What fuel types are available?
Relevant articles
The Best Midsize SUVs in 2026
The midsize SUV segment is growing fast and fiercely competitive. Terrible models are few and far between; what you will find are 50 shades of better or best.
Best Lexus Deals in June 2026
Leasing a Lexus can be a great way to get into a new car from one of the most popular luxury brands at a more affordable monthly rate. Here are the best deals we've found this month on Lexus vehicles.
The Best Used Luxury SUVs in 2026
No matter how you look at it, today’s automotive market is dominated by SUVs, in particular compact SUVs. The "not-a-minivan" family haulers have become so popular and profitable for automakers that many have stopped making cars in favor of building more SUVs in recent years.
