Chrysler conducted a full redesign for the Town & Country in 2001, bringing the long-running minivan into its fourth generation. Trim levels are the same: buyers can choose between LX, LXi, and Limited, each available in FWD and AWD. A new EX trim is also available for 2001. Chrysler has also added a power lift gate, removable center console, and additional power outlets. The Town & Country's RS platform is also new this year, replacing the previous NS foundation.

The same two Town & Country engine options are carried over from the previous generation. The front-wheel drive LX and LXi models are the only models to house the 3.3 liter Flex Fuel V-6, which provides 180 horsepower and 210 pound-feet of torque. A four-speed automatic is paired with this engine, and fuel economy is estimated at 18/24 mpg. All other models, including the more modestly equipped EX, are powered by the 3.8 liter OHV V-6, generating 215 horsepower and 245 pound-feet of torque. Towing capacity with the 3.8 liter engine is 3500 pounds. Fuel economy drops to 17/22 mpg.

Used car shoppers should note that this model year predates Chrysler's flexible and convenient "Stow N Go" seating, which arrived later in the fourth generation. The lack of configurable seating is a downside to these older Town & Country models.

All models are considerably well-appointed, but the addition of extra amenities can become very costly. Owners have expressed satisfaction with the overall ride quality and car-like handling, generous standard features and safety (especially on the AWD models). However, the Town & Country is still hampered by Chrysler's reliability issues. Common complaints include very frustrating experiences with dealer service, heat and A/C malfunction, faulty electrically systems, and transmission flaws.