2006 Pontiac Grand Prix Shut off while driving

First thing to do is to had the car scanned for error codes. Knowing them will point you in a direction so you are not just replacing parts and crossing your fingers. Take the car to a parts store. They will usually do this for free ('cause they want to sell you the parts while you are there).

It is reading 02 sensors and injectors . So what could be going on?

Check you injectors wiring harness! Check the fuse for the fuel injection system. You can find the fuse on the panel under your hood, above the battery compartment. Check the wiring for visible damage at each injector connector and follow the wires back into the harness, you may need to extract the main harness from the protective plastic casing at certain parts in order to accomplish this, reply and I will help as much as I can I have one of these with over 330,000 miles, they run forever if you just know who to talk to about the simple inexpensive fixes required throughout their lifetime