Used 2022 Mercedes-Benz S-Class S 580 4MATIC AWD for SaleNationwide
254 vehicles found
Shop with transparent pricing.
Only show listings that include dealer fees- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Grey Exclusive Nappa Leather)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 21,968
- Stock #:
- 23418N
- VIN:
- W1K6G7GB4NA081792
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
21,968 mi
Alexandria, VA
Good Deal
$70,994
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Cirrus Silver Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 67,280
- Stock #:
- P149494
- VIN:
- W1K6G7GB8NA149494
Price drop
-$1,589
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
67,280 mi
Macon, GA
Good Deal
$57,185
$55,596
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 61,808
- Stock #:
- ATN004793A
- VIN:
- W1K6G7GB9NA148693
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
61,808 mi
Duluth, GA
Great Deal
$52,173
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Kalahari Gold
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,898
- Stock #:
- NA091547
- VIN:
- W1K6G7GB8NA091547
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,898 mi
Tulsa, OK
Great Deal
$62,116
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige/Magma Gray)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 30,131
- Stock #:
- CY23495A
- VIN:
- W1K6G7GB4NA131834
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
30,131 mi
Sarasota, FL
Good Deal
$66,514
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 47,397
- Stock #:
- NA079649A
- VIN:
- W1K6G7GB0NA079649
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
47,397 mi
Marietta, GA
Great Deal
$57,964
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Exclusive Carmine Red/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 7,996
- Stock #:
- 096844
- VIN:
- W1K6G7GB6NA096844
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
7,996 mi
Marietta, GA
Good Deal
$78,097
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Manufaktur Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 29,619
- Stock #:
- NA092687
- VIN:
- W1K6G7GB7NA092687
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
29,619 mi
Buena Park, CA
Good Deal
$66,118
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 19,521
- Stock #:
- 148212
- VIN:
- W1K6G7GB0NA148212
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
19,521 mi
Tempe, AZ
Good Deal
$70,387
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,573
- Stock #:
- 10619-TR
- VIN:
- W1K6G7GB6NA128241
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,573 mi
Joliet, IL
Good Deal
$67,353
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Gray/Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 37,461
- Stock #:
- 7530
- VIN:
- W1K6G7GB9NA152047
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
37,461 mi
Marietta, GA
Good Deal
$63,298
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 54,295
- Stock #:
- 15412
- VIN:
- W1K6G7GB9NA158656
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
54,295 mi
Jacksonville, FL
Fair Deal
$60,578
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 82,114
- Stock #:
- 68849
- VIN:
- W1K6G7GB8NA068849
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
82,114 mi
Fort Lauderdale, FL
Fair Deal
$50,894
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Silver
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 37,431
- Stock #:
- 148268T
- VIN:
- W1K6G7GB5NA148268
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
37,431 mi
Carrollton, TX
Good Deal
$64,924
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 26,005
- Stock #:
- NA118510
- VIN:
- W1K6G7GB1NA118510
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,005 mi
Alpharetta, GA
Good Deal
$66,096
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Silver Grey/Black
- Transmission:
- Automatic
- Mileage:
- 33,001
- Stock #:
- 25W3617A
- VIN:
- W1K6G7GB4NA139710
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
33,001 mi
Harvey, LA
Good Deal
$66,400
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- MANUFAKTUR Diamond White
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma Grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,936
- Stock #:
- CGSP16604
- VIN:
- W1K6G7GB3NA166672
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,936 mi
Lomita, CA
Good Deal
$64,080
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Selenite Gray Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- 9-Speed Automatic
- Mileage:
- 5,970
- Stock #:
- L5115W
- VIN:
- W1K6G7GB7NA163466
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
5,970 mi
Miami, FL
Great Deal
$73,239
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato&Magma Grey Leather)
- Mileage:
- 35,062
- Stock #:
- 142757
- VIN:
- W1K6G7GB1NA142757
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
35,062 mi
Burbank, CA
Good Deal
$63,065
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Transmission:
- 9-Speed Automatic
- Mileage:
- 25,250
- Stock #:
- 096873
- VIN:
- W1K6G7GB2NA096873
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
25,250 mi
Pawtucket, RI
Fair Deal
$73,846
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Rubellite Red
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Gray (Macchiato/Magma grey)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 31,025
- Stock #:
- NA098933A
- VIN:
- W1K6G7GB4NA098933
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
31,025 mi
Collierville, TN
Good Deal
$68,890
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Black
- Transmission:
- Automatic
- Mileage:
- 26,601
- Stock #:
- AHCTNA088073
- VIN:
- W1K6G7GB7NA088073
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
26,601 mi
Centennial, CO
Fair Deal
$70,099
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Nautical Blue Metallic
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Sienna Brown/Black
- Transmission:
- Automatic
- Mileage:
- 17,501
- Stock #:
- NA117982
- VIN:
- W1K6G7GB4NA117982
New arrival
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
17,501 mi
Maitland, FL
Good Deal
$72,018
- Year:
- 2022
- Make:
- Mercedes-Benz
- Model:
- S-Class
- Body type:
- Sedan
- Doors:
- 4 doors
- Drivetrain:
- All-Wheel Drive
- Engine:
- 496 hp 4L V8
- Exterior color:
- Black
- Combined gas mileage:
- 20 MPG
- Fuel type:
- Gasoline
- Interior color:
- Brown (Macchiato Beige / Magma Grey E)
- Transmission:
- 9-Speed Automatic
- Mileage:
- 34,516
- Stock #:
- M6050A
- VIN:
- W1K6G7GB2NA113283
2022 Mercedes-Benz S-Class
S 580 4MATIC AWD
34,516 mi
Columbia, MO
Good Deal
$65,279
FAQs
How much does the Mercedes-Benz S-Class S 580 4MATIC AWD cost?
The average Mercedes-Benz S-Class S 580 4MATIC AWD costs about $63,799.71. The average price has decreased by -2.9% since last year. The 546 for sale on CarGurus range from $50,794 to $105,674 in price.
How many Mercedes-Benz S-Class S 580 4MATIC AWD vehicles have no reported accidents or damage?
480 out of 546 for sale have no reported accidents or damage.
What is the fuel economy of the Mercedes-Benz S-Class S 580 4MATIC AWD?
Depending on the engine and options, the Mercedes-Benz S-Class S 580 4MATIC AWD gets between 20 and 20 MPG/MPGe.
What fuel types are available?
Gasoline engines are available.
*CarGurus meticulously monitors the prices of millions of pre-owned vehicle listings, offering users precise and up-to-date market insights. Historical pricing data excludes any additional dealer fees as of May 3, 2026.
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