What type of fuel works best on 2010 lexus rx350?

I always use tip tier gasoline, like Shell, Mobil. Are you asking about Octane rating? Lexus recommends 91 Octane. You can use lower if you don't have knocking or pinging, most newer cars had knock sensors to handle it. I always go by what the Manufacturer recommends.

Thanks Tom, I was asking about regular,? mid grade? or premium?

On my wife's RX we had done mileage checks using different octaines and it always got better highway MPG on the good stuff and the power was better, she was traveling a lot back then. Then after she got a local job she hit head on by a Chevy pickup, he crossed the center line during a foggy morning, the RX's air bag system saved her life, she was hurt but it could have been worse, at least that is what the police said. If you do buy it have it completely serviced, change all fluids, and depending on mileage, belts and hoses, especially the timing belt. After you have the trans serviced add some Lube Guard for Toyota transmissions, as the trannys are the weak point on these cars. Hope this info has helped.

Thanks so much. It's at 72,000 miles. Definitely going to get warranty. I don't do much freeway driving but daily commute is less that 10 ,miles. I thought 2010 transmissions had no problems, that's why I stayed away from 08-09.

Yes they are looking better but why take a chance, Lube Guard products great for preventative maintenance. And here is another thing I've have been hearing about, some of the transmission re-builders are requiring that an auxiliary transmission cooler be put on in place of the one built into the radiator, they claim that the newer vehicles run too hot and is causing the fluids to break down. Just something to think about.

My wife has a RX400H and always uses regular gasoline which is recommended in the handbook. The engine is made for regular gas, the higher grade will not make any difference except it will lighten your purse just a little bit. I have had no issue with the transmission or anything. I have 135K or so miles and she refuses to part with it.

But is a 2010 lexus rx350 is a good car and body recommended it.

I would not buy a RX 350 of any year after reading all the problems the owners have. Actually I would not buy another Lexus. Hundai with 10 yr warranty is an alternative.