Misfire 2001 dodge ram 1500 5.9 v8

Billy Ott

Asked by Apr 16, 2016 at 11:04 PM about the 2001 Dodge Ram 1500 4 Dr SLT Quad Cab SB

Question type: General

My trucks heater core went and that caused
my water pump seal to leak. Right before
that my truck started to shake and run
rough. I scanned it and it threw the random
misfire codes for cylinders 3 4 5 6, which
are the middle cylinders. Help!!!!!!

3 Answers


Did it overheat before you shut it down?


P0300 DODGE - Cylinder Misfire Fault Detected Random Cylinders.... Possible causes - Faulty spark plug (s) - Faulty ignition coil (s) - Clogged or faulty fuel injector (s) - Intake air leak - Fuel injectors harness is open or shorted - Fuel Injectors circuit poor electrical connection - Ignition coils harness is open or shorted - Ignition coils circuit poor electrical connection - Insufficient cylinders compression - Incorrect fuel pressure.... The P0300 code means that a cylinder(s) is misfiring or is randomly misfiring. Start by checking for intake leaks, intake gaskets are common caused of multi-cylinder misfiring. If no leak are found the next step is to replace the spark plugs. If the problem persist more tests needs to be done to diagnose problem.


I have never heard of a heater core taking out a water pump unless the engine has overheated and made too much pressure and blew it. So if that is the case then the likely hood of a blown head gasket is very high, and as you seem to have the problem on all of the center cylinders I would be leaning in that direction, your still going to have to fix the heater core and the pump no matter what you do.

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