Can I change picture on my startup screen in a 2017 es350 Lexus
Try reading your owners manual, it will have the procedure.
Couldn't find anything after 2014
Load any pictures in a flash drive, then plug it in one of your usb port in the vehicle. A message should appear on your navigation screen, just follow the steps, its just like saving a picture on your computer and use it as a screen saver, good luck.
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