The 2006 Chrysler 300 Touring went unchanged in its second model year. The 300 series had been totally reinvented for 2005, as the cab-forward body vanished in favor of a look very reminiscent of British super-luxury cars like Bentley and Rolls Royce. While its shape may have been inspired by overseas design, the 300 was unmistakably American.

The Touring 300 would utilize a larger V6, upgrading from 2.7 to 3.5 liters. The new V6 brought this more upscale 300 a 60 horsepower increase, from 190 to 250. Torque was given the same boost: from 190 to 250 pound-feet. The Touring 300's engine was paired with the same 4-speed automatic used by the base model, but AWD was now available. The rear-wheel-drive Touring had slightly better fuel efficiency, at 19/27 mpg. While all 300s are built off the Chrysler LX platform, a close derivative of the Mercedes E-Class, the Touring model softened suspension for a more forgiving ride.

Owners of the 300 Touring model were spread across the spectrum of the value question. Many claimed that this was the best value they had ever found in a car. Others felt that the limited 2006 recall of this model was more representative of their entire 300 experience. Some reported averaging a significant service trip every 2-3 months within the first two years of ownership.