The Porsche Cayenne S Titanium Edition was powered by a 4.5-liter V8 that produced 340 horsepower. It was linked to a six-speed Tiptronic S automatic transmission, which was standard. The Tiptronic was equipped with a gate that enabled the driver to shift manually, depending on driving conditions.
Standard features for the all-wheel-drive Cayenne  S Titanium Edition included a two-tone leather interior, aluminum-colored instrument dials, a three-spoke leather-wrapped steering wheel, 12-way adjustable power front seats, heated exterior mirrors, cruise control, an air-cooled glovebox, front and side airbags, a four-tube sport tailpipe, front and rear fog lamps, automatic climate control, 19-inch titanium wheels, and a Porsche Communications Management system with DVD navigation and an MP3-compatible CD radio.
Options included heated rear seats, Park Assist, a Bose stereo system, an air suspension system, and variable assist power steering.
Drivers praised the Cayenne S Titanium Edition's acceleration, tight handling, roominess, and comfortable seating. However, the Titanium Edition's six-speed automatic was a bit controversial, especially with reviewers, who noted that it tended to accelerate the vehicle even when the foot was held constant on the gas pedal. The six-speed also could be a bit jumpy on downshifts, reviewers noted.