The Chevrolet Astro LS received several changes for 2000. Besides the improved antilock braking system and reworked engine for quieter operation, the 2000 Chevy Astro LS featured a remote keyless entry system, cloth bucket seats, a 27-gallon plastic gas tank, and chrome wheels as standard equipment. Chevrolet added a battery-rundown protection system and lockout protection in 2000; in addition, accessories could run for up to 20 minutes after ignition shutoff.  

As with most Chevy Astro years, the 2000 LS thrilled its many fans with its roomy interior, comfortable ride, and ability to park it in a garage despite its size. However, many 2000 Chevy Astro LS owners complained of cramped leg space in the front, electrical problems, and other mechanical problems.