The 2000 Toyota Sienna saw very few changes from the previous model year. New additions did include an upgraded sound system and the availability of a sports package on the higher-level trims.

The 2000 Sienna came in three trim levels: the base CE, the midrange LE, and the high-end XLE. The CE is for minimalists only, with air conditioning, power windows, power locks, and a cassette player all optional. The LE is better equipped, and the XLE includes luxury-like amenities, such as leather trimmed seating and a power moon roof. All models but the CE come standard with a second sliding door. The engine is a 3.0 liter, 194 horsepower V6 that gets about 18/24 mpg.

Drivers like the Sienna for its car-like handling and Toyota reliability. Many drivers wish the 2000 Sienna had more cargo space, or at least that the rear seats would fold down all the way.